CFB Game Prediction

USC vs Michigan Prediction & Betting Tips for CFB Week 7 on 10/11/2025

Want our best USC vs Michigan prediction for 10/11/25? Get our College Football betting tip as the Michigan travel to USC in Week 7 on 10/11/25 at Los Angeles Memorial Coliseum, in USC. Knup Sports has your free CFB pick!

Week 7 of the 2025 college football season brings an exciting matchup between the Michigan Wolverines and the USC Trojans. The game will be played at the Los Angeles Memorial Coliseum, providing a scenic outdoor setting for this Big Ten conference battle. Scheduled for a prime-time kickoff at 7:30 PM, fans can catch the action live on NBC.

The Michigan Wolverines, ranked 15th in both the AP and Coaches Polls, enter this game with a 4-1 record. They are coming off a strong performance against the Wisconsin Badgers, securing a 24-10 victory at home. With a conference record of 2-0, Michigan looks to continue their momentum on the road where they hold a 1-1 record this season.

Meanwhile, the USC Trojans also boast a 4-1 record, having demonstrated their offensive capabilities in previous games. Despite a recent close loss to Illinois, the Trojans maintain a perfect 3-0 record at home. With a 2-1 conference record, they will aim to leverage home-field advantage to secure a win against a ranked opponent.

USC vs Michigan At a Glance

  • Game Location: Los Angeles Memorial Coliseum, Los Angeles, CA
  • Game Date & Time: Saturday, October 11, 2025 at 7:30 PM
  • Broadcast: NBC
  • Weather: Outdoor game conditions
  • Team Records: Both Michigan Wolverines and USC Trojans are 4-1 this season
  • Game Odds: USC is favored with a moneyline of -139 and a spread of -2.5

USC Trojans: A Look into the Upcoming Game

Team Overview

The USC Trojans have demonstrated a strong offensive presence in the 2025 season, ranking 5th with 242 points. Their passing game is particularly noteworthy, ranking 8th with 1,690 passing yards. On the ground, they have amassed 1,136 rushing yards, placing them 23rd.

Defensively, USC is a force to be reckoned with in terms of pressuring the quarterback. They rank 7th in sacks with 17 and interceptions with 6, highlighting their ability to disrupt opposing offenses. Their defense has allowed 115 points this season, ranked 63rd, showing room for improvement in containing opponents.

Recent Game Performances

The Trojans experienced a narrow loss to Illinois with a score of 34-32. Despite the loss, their offense outpaced Illinois in passing yards with 364. They also secured more first downs, with 29 compared to Illinois’ 25.

In their victory over Michigan State, USC showcased their offensive versatility with 234 passing yards and an impressive 289 rushing yards. This balanced attack led to a 45-31 victory. Their defense limited Michigan State to only 112 rushing yards, emphasizing their ability to control the ground game.

Player Highlights

Quarterback Jayden Maiava has been pivotal in USC’s offense, with 1,587 passing yards and 11 touchdowns. He ranks 5th in the league for passing yards, indicating his importance to the team’s offensive strategy.

Running back Waymond Jordan is another key contributor with 537 rushing yards and 5 touchdowns, ranking 10th in the league. His performance has been instrumental in establishing USC’s ground game dominance.

Injury Concerns

USC faces some injury challenges heading into their next game. Key players such as Bryan Jackson (RB) and Zacharyus Williams (WR) are questionable due to undisclosed injuries. The absence of these players could impact USC’s depth and versatility.

Chasen Johnson (CB) is out for the season with a knee injury, which might affect the Trojans’ defensive backfield. Despite these setbacks, the team has depth across its roster to compensate.

Betting Trends

  • O/U – Home Games: 23-7 (76.7%) over the last 30 games.
  • SU – Home Games: 19-6 (76.0%) over the last 25 games.
  • SU – As Favorite: 22-8 (73.3%) over the last 30 games.
  • O/U – After Win: 17-6 (73.9%) over the last 23 games.
  • O/U – As Favorite: 20-8-1 (69.0%) over the last 29 games.
  • SU – After Loss: 3-0 (100.0%) over the last 3 games.
  • ATS – After Loss: 3-0 (100.0%) over the last 3 games.
  • O/U – Totals ≥ 50: 20-9-1 (66.7%) over the last 30 games.

Michigan Wolverines Prepare for Showdown with USC Trojans

USC Trojans Offense

The USC Trojans are renowned for their high-octane offense that can put points on the board rapidly. With a balanced attack, they effectively utilize both their passing and rushing games to keep defenses guessing. Their offense thrives on explosive plays, which could be a challenge for the Wolverines’ defense.

Quarterback play is a crucial component of the Trojans’ success. Their signal-caller is adept at making quick decisions and spreading the ball around to multiple targets. The Trojans’ offensive line plays a pivotal role in providing ample protection, allowing their quarterback to operate efficiently.

USC Trojans Defense

Defensively, the USC Trojans are known for their aggressive approach and ability to create turnovers. Their defensive line is particularly strong, often disrupting opponents’ backfields and putting pressure on opposing quarterbacks. This unit’s ability to generate sacks and force fumbles could pose a significant test for Michigan’s offense.

The secondary for the Trojans is also a key element of their defense, with cornerbacks and safeties capable of making game-changing interceptions. Their ability to shut down opposing wide receivers will be critical in minimizing Michigan’s aerial threats. USC’s defense will aim to capitalize on any mistakes made by the Wolverines.

Special Teams and Intangibles

Special teams often play a crucial role in tight games, and the Trojans boast a reliable kicking game. Their kicker has a strong leg and can convert field goals from long distances, providing an additional scoring threat. Punting can also be a weapon, helping to win the field position battle.

Intangibles, such as playing at home in the Los Angeles Memorial Coliseum, give the Trojans an added advantage. The atmosphere and crowd support could be factors that influence the outcome. The Trojans will look to harness the energy from their home fans to gain an edge over the Wolverines.

Team Betting Trends

  • USC has a strong record in home games over the past few seasons.
  • The Trojans tend to perform well against ranked opponents, showcasing their ability to rise to the occasion.
  • Games featuring USC have frequently hit the over, reflecting their offensive prowess and occasional defensive vulnerabilities.
  • USC has covered the spread consistently when playing as favorites, indicating their ability to meet or exceed expectations.

USC vs Michigan Prediction: Over 57.5

Saturday’s game features two teams that have been consistently putting up points this season. USC ranks 5th in points scored with 242 points, and Michigan has notched 164 points, ranking 41st. Both teams have also been strong at home and away respectively, indicating their ability to maintain offensive pressure regardless of the venue.

USC has shown a tendency to perform well in high-scoring games, especially when the total is set at 50 or higher. Over the last 30 games with such totals, USC has gone 20-9-1 on the Over. Given their offensive capabilities and home trends, this matchup seems poised for a high-scoring outcome.

Michigan’s defense is ranked 40th in points allowed, which, while solid, may struggle against a USC team that ranks in the top 10 for passing yards. Additionally, Michigan’s road performance has been less dominant compared to their home record, potentially allowing more scoring opportunities for USC.

Combining these offensive and defensive factors, the game is likely to surpass the total of 57.5. Expect both teams to capitalize on their offensive strengths and push the final score beyond the threshold.

  • USC vs Michigan Prediction: Over 57.5
  • USC vs Michigan Score: USC 38 – Michigan 31
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