MLB Game Prediction

St. Louis Cardinals vs San Francisco Giants Prediction & Betting Tips for 9/7/2025

Want our best St. Louis Cardinals vs San Francisco Giants prediction for 9/7/25? Get our MLB betting tip as the Giants travel to the Cardinals on 9/7/25 at Busch Stadium, in St. Louis. Knup Sports has your free pick!

The San Francisco Giants, under manager Bob Melvin, head into Busch Stadium with a record of 72-70 and sit third in the NL West. They have been strong in their last ten games, posting an 8-2 record. Despite their recent loss to the St. Louis Cardinals, they look to rebound as they continue their road stretch.

On the other side, the St. Louis Cardinals, managed by Oliver Marmol, hold a 71-72 record, placing them fourth in the NL Central. The Cardinals come off a narrow 3-2 victory against the Giants, which broke their losing streak. With a 6-4 record over their last ten, they aim to maintain momentum in front of their home crowd.

This afternoon game at Busch Stadium is set to take place in clear weather, providing ideal conditions for baseball. The Giants have a road record of 37-36, while the Cardinals boast a home record of 40-34. Both teams are closely matched, setting the stage for an intriguing contest with postseason implications.

Cardinals vs Giants At a Glance

  • Location: Busch Stadium in St. Louis, MO
  • Game Date: Sunday, September 7, 2025 at 2:15 PM
  • Weather: Clear sky with a mild day and a light breeze
  • TV Channel: FDSMW
  • Giants Moneyline Odds: +125
  • Cardinals Moneyline Odds: -149

Cardinals Aim to Soar Over the Giants: A Closer Look at the San Francisco Lineup

Giants’ Hitting Overview

The San Francisco Giants enter the game with a batting average of .246, ranking them 11th in the league. Their on-base percentage of .313 puts them in 10th place, showing a decent ability to get players on base. However, their slugging percentage is .382, which ranks 24th, indicating a potential lack of power in their lineup.

While the Giants have hit 136 home runs this season, they rank 22nd in the league for this stat. This suggests that their power hitting may not be a consistent threat. They have managed to hit 230 doubles, placing them 11th, showcasing their ability to find the gaps in the field.

Key Players to Watch

Kai-Wei Teng will take the mound for the Giants, bringing with him an ERA of 7.23 and a WHIP of 1.71. Teng’s record of 2-3 indicates some struggles this season, making it crucial for the Giants’ offense to provide ample support. His ability to limit the Cardinals’ offense will be a key factor in the Giants’ chances.

San Francisco’s offense has relied on their ability to draw walks, with a total of 423 this season, ranking them 21st. Their strikeout count stands at 1135, placing them 8th in the league, indicating a balance between patience and aggression at the plate. The Giants’ strategy will likely focus on putting pressure on the Cardinals’ pitching staff.

Pitching Challenges

The Giants’ pitching staff faces challenges, with an earned run average (ERA) of 4.29, ranked 21st. This suggests that San Francisco’s pitchers have had difficulty keeping opposing offenses in check. Their batting average against is .258, which ranks 20th, further highlighting their pitching struggles.

Home runs allowed have been a significant issue, with the Giants giving up 148, placing them 5th in the league. This vulnerability to the long ball could be a deciding factor if the Cardinals’ hitters capitalize on Teng’s pitches. The Giants’ bullpen will need to be sharp to maintain any lead they can build.

Team Betting Trends

  • Giants have a .500 record in day games, with 27-31.
  • San Francisco’s runline as underdog stands strong at 48-31.
  • The Giants struggle with totals of 9 or more, holding a 20-22 record.
  • When the Giants score 5 or more, their runline is an impressive 48-16.
  • In away games, the Giants have a runline of 36-33.

Giants Look to Strike Gold Against the Cardinals

Cardinals’ Offensive Overview

The St. Louis Cardinals bring a balanced offensive unit into their game against the Giants. With a season batting average of .239, they rank 16th in the league, indicating a mid-tier performance. However, their on-base percentage of .313 is ranked 10th, showing that they effectively get players on base.

Home runs have been a significant aspect of the Cardinals’ offense, with 152 homers placing them 16th in the league. Additionally, they’ve managed 211 doubles, ranking 22nd, showcasing their capability for extra-base hits.

Key Players to Watch

Cardinals’ power-hitting is led by several key players contributing significantly to their home run tally. Their ability to hit the long ball could play a crucial role in their game strategy against the Giants. Observers should keep an eye on their leading hitters who can change the game’s dynamic with a single swing.

Despite their power, the Cardinals have also shown the ability to be patient at the plate, ranking 8th in walks with 477. This patience could prove advantageous in drawing out Giants’ pitching and creating scoring opportunities.

Cardinals’ Pitching Insights

The Cardinals have a strong pitching lineup, with an earned run average of 3.78 that ranks them 6th in the league. Their pitching staff has limited opposing hitters to a .246 batting average against, placing them in the middle of the pack at 15th.

One of the standout features of their pitching is their ability to prevent home runs, leading the league with only 123 homers given up. Additionally, they have achieved 55 quality starts, which ranks them 9th, underscoring their rotation’s consistency.

Betting Trends for the Cardinals

  • SU Last 3 Games: 1-2 (33.3%)
  • SU Last 5 Games: 2-3 (40.0%)
  • Runline Last 3: 2-1 (66.7%)
  • O/U Last 3: 2-1 (66.7%)
  • O/U All Games: 70-72 (49.3%)

Cardinals vs Giants Prediction: Over 7.5

The St. Louis Cardinals and San Francisco Giants are slated to play at Busch Stadium, featuring starting pitchers Kai-Wei Teng for the Giants and Sonny Gray for the Cardinals. Teng has struggled this season with a 7.23 ERA, suggesting the Cardinals might have scoring opportunities. Gray’s 4.43 ERA isn’t dominant, indicating the Giants might also capitalize offensively.

In their recent head-to-head matchups, both teams have shown the potential to score runs. With the Cardinals winning a 3-2 nail-biter and the Giants taking an 8-2 victory in the previous two games, the combined offensive potential suggests a game that could exceed the current total set at 8.0.

The Cardinals have been efficient in their home games with a record of 40-34, and their slugging percentage ranks 24th, indicating they can find ways to score at home. The Giants, despite their recent loss, are 8-2 in their last 10 games, showing they can consistently produce offensively on the road.

Considering the pitching vulnerabilities and recent offensive performances, an outcome where both teams contribute to a higher total score seems likely. Therefore, the pick for this matchup is the ‘Over 7.5,’ with a projected final score of Cardinals 6 – Giants 4.

  • Cardinals vs Giants Prediction: Over 7.5
  • Cardinals vs Giants Score: Cardinals 6 – Giants 4
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