MLB Game Prediction

St. Louis Cardinals vs San Francisco Giants Prediction & Betting Tips for 9/5/2025

Want our best St. Louis Cardinals vs San Francisco Giants prediction for 9/5/25? Get our MLB betting tip as the Giants travel to the Cardinals on 9/5/25 at Busch Stadium, in St. Louis. Knup Sports has your free pick!

The San Francisco Giants, with a record of 71-69 and currently third in the NL West, come into this game riding a four-game winning streak. Their recent performance has been impressive, winning nine of their last ten games. Manager Bob Melvin will be looking to continue this momentum as his team takes on the St. Louis Cardinals at Busch Stadium.

Meanwhile, the St. Louis Cardinals hold a 70-71 record and stand fourth in the NL Central. They’ve won their last two games and went 6-4 in their last ten outings, showing signs of improvement under the guidance of manager Oliver Marmol. The Cardinals have a solid home record this season, which could play to their advantage in this night game.

Set against the backdrop of overcast skies and mild weather, the Giants and Cardinals are poised for an intriguing encounter. With both teams having something to prove, the game is expected to be competitive, especially with the Giants’ recent form. Fans can catch the action on FDSMW, with the first pitch scheduled for 8:15 PM.

Cardinals vs Giants At a Glance

  • Game Location: Busch Stadium in St. Louis, MO
  • Giants Recent Form: 71-69 record, 3rd in NL West, on a 4-game winning streak
  • Cardinals Recent Form: 70-71 record, 4th in NL Central, on a 2-game winning streak
  • Weather: Overcast clouds with a mild breeze
  • Broadcast Info: Tune in to FDSMW for live coverage
  • Game Odds: Giants moneyline at -102, Cardinals at -116

Cardinals Prepare for a Showdown with the Giants

Giants’ Hitting Overview

The San Francisco Giants bring a batting average of .247 to this matchup, which ranks them 11th in the league. Their on-base percentage sits at .314, placing them 12th overall, showcasing a solid approach at the plate.

Despite ranking 22nd in slugging percentage at .384, the Giants have demonstrated power potential with 135 home runs, though this ranks them 24th. Their ability to hit for doubles is notable, with 229, ranking them 8th in the league.

Key Giants Players to Watch

The Giants’ offense will lean on players who can create opportunities and drive in runs. With 421 walks, their discipline at the plate has been a key factor in their offensive strategy.

While their home run count is modest, their ability to strike out 1121 times, ranking 9th, suggests they can still make contact and put the ball in play effectively. This skill set could challenge the Cardinals’ pitching staff.

Giants’ Pitching Analysis

On the mound, the Giants’ pitching staff holds an ERA of 4.28, which positions them 20th in the league. Opponents have batted .257 against them, placing their pitching staff 19th in this category.

Despite giving up 146 home runs, ranking 6th in the league, the Giants have managed to secure 49 quality starts, placing them 11th. Their ability to limit damage in crucial situations will be crucial against the Cardinals.

Impact of Giants’ Starter: Carson Seymour

Carson Seymour will be taking the mound for the Giants, bringing an ERA of 4.74 and a WHIP of 1.50. His win-loss record stands at 0-2, indicating some struggles this season.

Seymour’s performance will be pivotal as he faces a Cardinals lineup capable of producing runs. His ability to navigate through the Cardinals’ order will be a determining factor in the outcome of the game.

Giants’ Betting Trends

  • SU in Night Games: 43-40 (51.8%)
  • SU in Away Games: 31-38 (44.9%)
  • Runline as Underdog: 47-31 (60.3%)
  • O/U as Underdog: 39-39 (50.0%)
  • O/U After a Loss: 38-33 (53.5%)

Giants Aim to Continue Streak Against Cardinals

Offensive Performance

The San Francisco Giants are currently on a remarkable run, having won 10 of their last 11 games. Their recent offensive output has been a significant factor, with the team hitting home runs in 17 consecutive games. This power surge is a key reason for their push in the National League wild-card race.

Rafael Devers has been a standout performer for the Giants, leading the team with 30 home runs and 97 RBIs. His consistent contributions make him a pivotal player as they face the St. Louis Cardinals. Heliot Ramos and Willy Adames have also been essential, adding depth to the lineup with their respective 16 and 26 home runs.

Pitching and Defensive Outlook

While the Giants’ offense has grabbed headlines, their pitching staff has been solid, holding a 3.80 ERA, which ranks sixth in the league. Despite facing injuries, the staff has managed to contain opposition scoring effectively. Carson Seymour will take the mound against the Cardinals with hopes of improving his current ERA of 4.74.

The Giants’ defense has also played a crucial role, limiting mistakes and supporting their pitchers. This combination of reliable pitching and sharp defense is a strength they will rely on against the Cardinals’ lineup.

Key Players to Watch

Matt Chapman has been in the spotlight, both for his performance and his appeal of a one-game suspension. His recent two-homer game against the Rockies demonstrates his offensive capabilities. Drew Gilbert, though less experienced, has been a surprise contributor and will be one to watch in this series.

Patrick Bailey, the team’s catcher, has been showcasing his defensive skills, which include crucial plays at the plate. His ability to manage the pitching staff and contribute offensively will be vital against the Cardinals.

Team Betting Trends

  • SU Last 3 Games: 3-0 (100.0%)
  • Runline Last 3: 3-0 (100.0%)
  • O/U Last 3: 2-1 (66.7%)
  • SU All Games: 71-69 (50.7%)
  • SU as Favorite: 45-38 (54.2%)
  • Runline as Underdog: 33-24 (57.9%)
  • O/U in Away Games: 38-33 (53.5%)

Cardinals vs Giants Prediction: Over 7.5

The San Francisco Giants are entering this game with an impressive momentum, having won 10 of their last 11 games. Their offense has shown significant improvement, hitting home runs in 17 consecutive games. This recent power surge is a key factor that could lead to a high-scoring game.

Despite the Cardinals focusing on evaluating young players, they remain competitive, boasting a 6-4 record in their last 10 games. With both teams possessing average pitching statistics, there is potential for a game with multiple scoring opportunities. Additionally, the Giants’ offensive strategy could capitalize on the Cardinals’ pitching to push the total over the line.

Looking at the starting pitchers, Carson Seymour and Michael McGreevy both have ERAs over 4.00, which suggests the potential for runs to be scored by both lineups. Combined with the Giants’ offensive momentum and the Cardinals’ competitiveness, the game appears primed for runs. The over/under line set at 8.0 is in a position that allows for this prediction of a higher score.

Based on these factors, the projected final score might be San Francisco Giants 6 – St. Louis Cardinals 4, which supports an ‘Over 7.5′ pick. The Giants’ offensive energy and the Cardinals’ ability to score make this a plausible outcome.

  • Cardinals vs Giants Prediction: Over 7.5
  • Cardinals vs Giants Score: Giants 6 – Cardinals 4
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