The NFL 2025 season kicks off with an NFC West showdown between the San Francisco 49ers and the Seattle Seahawks. Set to unfold at Lumen Field, the game features two divisional rivals eager to start their campaigns on a high note. With light rain forecasted, weather conditions may play a role in the game’s dynamics.
Led by head coach Kyle Shanahan, the 49ers come off a strong preseason, including victories over the Chargers and Raiders. However, their loss against the Broncos showed areas needing improvement, particularly in their passing game. On the other hand, the Seahawks, coached by Mike Macdonald, demonstrated their potential with a notable preseason win over the Chiefs, despite losses to the Packers and Raiders.
As the game unfolds, the 49ers are slight favorites with a -138 moneyline and a -2.5 point spread. The Seahawks, with a home field advantage, are looking to defy odds with a +117 moneyline and a spread of +2.5. Fans can catch the action live on FOX as both teams aim to make an early statement in the division.
Seahawks vs 49ers At a Glance
- Game Date and Time: Sunday, September 7, 2025 at 4:05 PM (Afternoon Game)
- Location: Lumen Field in Seattle, WA USA — Outdoor Field
- Weather: Mild day with a light breeze, and conditions described as ‘Light Rain’.
- Broadcast: TV Channel: FOX
- Odds: 49ers Moneyline -138; Seahawks Moneyline +117
- Spread: 49ers -2.5 (-111); Seahawks +2.5 (-108)
Seattle Seahawks: Preparing for a New Season
Offensive Performance Overview
The Seattle Seahawks concluded the last regular season with a total score of 375, ranking them 17th in the league. Their passing game was a strong point, with 4,020 yards, placing them 8th overall. However, the rushing attack lagged, with 1,627 yards and a 27th-place rank.
Despite these challenges, the Seahawks managed to secure 329 first downs, landing them in 15th place. Their third down conversion rate stood at 37.6%, which positioned them at 18th in the league.
Defensive Standpoint
Defensively, the Seahawks allowed an opponent score of 368, ranking them 11th. The team’s pass rush was effective, recording 45 sacks and placing them 6th overall. Their secondary was also formidable with 13 interceptions, ranking 7th.
The Seahawks demonstrated proficiency in forcing turnovers, recovering 5 fumbles, which earned them a 10th place rank. Opponent offensive yards totaled 5,656, placing Seattle 14th in the league for this category.
Preseason Performance Recap
In the 2025 preseason, the Seahawks had mixed results. They recorded a decisive 33-16 victory over the Kansas City Chiefs, showcasing a strong offensive output with 268 rushing yards. However, they faced a 20-7 defeat against the Green Bay Packers and a draw against the Las Vegas Raiders, which ended 23-23.
Key players during these games included Cody White, who recorded a touchdown and 69 receiving yards against the Packers, and Drew Lock, who threw two touchdown passes against the Chiefs. The team exhibited strong performances, but also areas that require improvement, particularly on the road.
Injury Report Concerns
The Seahawks have been dealing with multiple injuries heading into the season. Kenny McIntosh and AJ Finley are on the injured reserve list and will miss the entire 2025-2026 season. Additionally, Johnathan Hankins and Rylie Mills will miss at least four games due to their respective injuries.
On a positive note, Tory Horton has returned to full practice participation and is expected to be available for Week 1. Nevertheless, the team must navigate through several key injuries to maintain their competitiveness.
Team Betting Trends
- Seattle has covered the spread in 3 of their last 5 games.
- The total has gone over in 2 of the Seahawks’ last 5 games.
- Seattle is 4-1 in their last 5 home games.
- Against NFC opponents, Seattle is 6-4 in their last 10 matchups.
- The Seahawks have lost 3 of their last 5 road games.
San Francisco 49ers: Analyzing the Upcoming Game
Offensive Overview
The San Francisco 49ers finished their 2024 regular season with a solid offensive performance, ranking 4th in passing yards with 4,234 yards. They also accumulated 2,163 rushing yards, placing them 12th in the league. Their scoring capabilities were marked by 389 points, landing them in 13th place overall.
Their ability to convert on third downs was notable with a success rate of 42.6%, ranking 9th. This efficiency in maintaining drives will be crucial as they face the Seattle Seahawks in their first game of the 2025 season.
Defensive Challenges
Defensively, the 49ers have room for improvement, as they allowed 436 points, ranking them 26th in opponent scoring. However, they performed well in limiting opponent offensive yards, conceding 5,396 yards, which ranked them 8th.
Their pass rush was effective, producing 37 sacks (12th in the league), and their secondary also played a role with 11 interceptions, ranking 9th. These defensive stats will be key as they aim to suppress the Seahawks’ offensive efforts.
Key Players and Injuries
Brock Purdy led the team as quarterback with 3,864 passing yards and 20 touchdowns. However, the team faces challenges with injuries to key players like Brandon Aiyuk and Demarcus Robinson, impacting their receiving corps.
Running back Christian McCaffrey, although limited to four games in 2024, is expected to play a significant role if healthy. His versatility as a rusher and receiver can provide an edge against Seattle.
Recent Preseason Performance
In the 2025 preseason, the 49ers showed mixed results, winning two out of three games. They secured victories against the Los Angeles Chargers and Las Vegas Raiders but suffered a defeat to the Denver Broncos.
These games highlighted strengths and areas for improvement, such as improving their turnover margin and enhancing their offensive consistency. These lessons will be vital as they transition into the regular season.
Betting Trends
- 49ers are 5-1 ATS in their last 6 games as an underdog.
- 49ers are 4-1 ATS in their last 5 games in September.
- 49ers are 6-0 ATS in their last 6 road games.
- The total has gone OVER in 4 of 49ers’ last 5 games against Seattle.
Seahawks vs 49ers Prediction: Over 43.5
The San Francisco 49ers had a strong offensive performance in the 2024 season, ranking 4th in passing yards and 12th in rushing yards. They scored 389 points, placing them 13th in the league. With these statistics, they are likely to continue their offensive strength in the upcoming game.
On the other side, the Seattle Seahawks also demonstrated a solid offensive capability, ranking 8th in passing yards during the 2024 season. Although their rushing game was weaker, their overall offensive production suggests they can contribute to a high-scoring game. Their previous head-to-head meetings with the 49ers often resulted in high scores.
Defensively, the 49ers ranked 26th in opponent score, indicating potential vulnerabilities that Seattle can exploit. Additionally, the Seahawks ranked 11th in the same category, which might not be enough to completely suppress the 49ers’ offense.
Considering both teams’ offensive capabilities and defensive lapses, an over 43.5 seems plausible. The 49ers and Seahawks could potentially produce a final score reflecting their offensive strengths and defensive weaknesses.
- Seahawks vs 49ers Prediction: Over 43.5
- Seahawks vs 49ers Score: 49ers 28 – Seahawks 24
