MLB Game Prediction

San Diego Padres vs Milwaukee Brewers Prediction & Betting Tips for 9/22/2025

Want our best San Diego Padres vs Milwaukee Brewers prediction for 9/22/25? Get our MLB betting tip as the Brewers travel to the Padres on 9/22/25 at PETCO Park, in San Diego. Knup Sports has your free pick!

The Milwaukee Brewers, holding a strong record of 95-61 and sitting at the top of the NL Central Division, visit PETCO Park to take on the San Diego Padres. The Brewers are led by manager Pat Murphy and come into this game with a recent loss against the St. Louis Cardinals. Despite their defeat, the team has shown resilience in their last 10 games, securing a 6-4 record.

The San Diego Padres, managed by Mike Schildt, are second in the NL West with an 85-71 record. They are on a winning streak, having triumphed in their last two games, and also boast a 6-4 record in their past 10 games. The Padres have been strong at home this season, which could be a significant factor in this matchup against a challenging Brewers squad.

The game is scheduled for Monday, September 22, 2025, at 9:40 PM at PETCO Park, where the weather is predicted to be warm with a light crosswind. The Padres are slight favorites with odds of -128, while the Brewers stand at +109. Both teams are showing consistency in their recent performances, setting the stage for an intriguing game under the lights.

Padres vs Brewers At a Glance

  • Game Location: PETCO Park in San Diego, CA
  • Game Time: Monday, September 22, 2025 at 9:40 PM
  • Weather: Warm with a light breeze and few clouds
  • TV Broadcast: FDSWI
  • Brewers Record: 95-61, currently 1st in NL Central
  • Padres Odds: Moneyline -128

Padres Prepared for Brewers Battle: San Diego Seeks to Maintain Playoff Push

Brewers’ Offensive Overview

The Milwaukee Brewers have shown a solid performance with a batting average ranked 7th in the league at .252. Their on-base percentage stands at .318, placing them in 9th position. However, their slugging percentage is lower, ranking 20th at .388.

Home runs have been less frequent for the Brewers this season, ranking 25th with 142. They have managed a stronger showing in doubles with 248, sitting 13th in the league. Walks have been a consistent element of their game, with 489 walks earning them a 16th rank.

Key Players to Watch

Freddy Peralta stands out as a key figure for Milwaukee, boasting an impressive 17-6 win-loss record. His ERA of 2.65 and WHIP of 1.07 highlight his dominance on the mound. Peralta’s performance will be crucial in restricting the Padres’ bats.

Offensively, the Brewers rely on a collective effort rather than standout home run hitters. Their ability to get on base and manufacture runs will be pivotal against a strong Padres pitching lineup. Expect a strategic approach to capitalize on base runners.

Brewers’ Pitching Strength

The Brewers have excelled in pitching with a 3.69 ERA, ranking 3rd in the league. Their ability to restrict opponents to a .225 batting average places them at the top of the league. Limiting home runs has also been a strong point, with only 173 allowed.

Quality starts have been consistent with 47, placing them 15th in the league, while their bullpen has been reliable with only 16 blown saves, ranked 1st. Strikeouts have been frequent, with 1,367, earning them a 7th place in the league.

Team Betting Trends

  • Straight Up Last 10 Games: 6-4 (60.0%)
  • Runline All Games: 81-75 (51.9%)
  • Totals Over/Under All Games: 67-89 (42.9%)
  • SU as Favorite: 53-36 (59.6%)
  • Runline when Scoring 5+: 49-15 (76.6%)
  • O/U Totals ≥ 9: 12-18 (40.0%)

Brewers Look to Bounce Back in San Diego: A Deep Dive into the Brewers’ Matchup

Overview of the Brewers’ Recent Performance

The Milwaukee Brewers are coming off a recent stretch that has seen mixed results. They have gone 1-2 in their last three games, facing a tough series against the St. Louis Cardinals. Despite these setbacks, the Brewers have already clinched a playoff berth and are looking to solidify their standing in the postseason.

In their last outing against the Cardinals, the Brewers managed to outhit their opponents but struggled to convert opportunities, going 0-for-7 with runners in scoring position. This inability to capitalize on scoring chances will be a key area to watch in their upcoming games.

Key Players to Watch

Christian Yelich continues to be a driving force for the Brewers’ offense, nearing a milestone with 29 home runs this season. His power at the plate will be crucial for Milwaukee as they aim to improve their offensive output. Yelich’s ability to deliver in clutch moments could play a significant role in the Brewers’ success against the Padres.

Freddy Peralta is set to take the mound for the Brewers. With a stellar 2.65 ERA and 17 wins under his belt, Peralta has been a consistent performer. His matchup against the Padres’ Nick Pivetta will be a critical factor in determining the outcome of the game.

Offensive and Defensive Strengths

The Brewers boast a solid team batting average of .261, ranking second in the league, with an impressive on-base percentage of .332. Their ability to get on base consistently provides a foundation for scoring opportunities. Additionally, Milwaukee’s pitching staff has been formidable, with a team ERA of 3.62, ranking second in MLB.

Defensively, the Brewers have shown resilience, highlighted by Andruw Monasterio’s standout plays in the field. Their defensive prowess will be essential in supporting their pitchers and stifling the Padres’ offense.

Team Betting Trends

  • Straight Up (SU) All Games: 95-61 (60.9%)
  • Runline as Underdog: 44-19 (69.8%)
  • O/U All Games: 76-80 (48.7%)
  • SU in Away Games: 44-34 (56.4%)
  • Runline in Away Games: 48-30 (61.5%)

Challenges Ahead

Injuries have been a concern for the Brewers, with key players like Brandon Woodruff on the injured list. His absence might impact the depth of Milwaukee’s pitching rotation. Additionally, William Contreras is day-to-day with a hand injury, but his potential return could bolster the lineup.

The Brewers’ bullpen remains strong with Abner Uribe leading the charge, boasting a 1.74 ERA. His performance in relief situations will be vital as the Brewers navigate through tight contests.

Final Thoughts

As the Brewers head into their final road series against the San Diego Padres, they will look to capitalize on their strengths and address recent offensive shortcomings. Maintaining consistency at the plate and on the mound will be key to securing victories.

With Freddy Peralta leading the charge, the Brewers have a solid chance to rebound and finish the regular season on a high note, solidifying their position for the upcoming postseason.

Padres vs Brewers Prediction: ‘Under 7.5’

The Brewers come into this game with a strong pitching performance led by Freddy Peralta, who has a 2.65 ERA and a record of 17-6. His consistency on the mound could limit the Padres’ offensive opportunities, especially given San Diego’s recent performance against strong pitching. The Padres have struggled offensively against quality pitchers, which could set the tone for a low-scoring game.

On the other side, the Padres’ starter Nick Pivetta has a solid 2.81 ERA this season, despite his career struggles against the Brewers. With both teams featuring top-tier pitching and considering the Padres’ home games have trended under this season (31-44 O/U), a low-scoring game seems likely. This supports an ‘Under’ pick for this matchup.

The head-to-head record this season also favors the under, with three consecutive games ending below the total. Both teams have demonstrated strong pitching capabilities, and with the stakes high as they approach the postseason, expect a strategic, defense-oriented game.

Considering these factors, along with the weather conditions at PETCO Park, the final score is projected to be low. A scoreline of Padres 3 – Brewers 2 seems feasible, favoring the under 7.5.

  • Padres vs Brewers Prediction: Under 7.5
  • Padres vs Brewers Score: Padres 3 – Brewers 2
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