MLB Game Prediction

San Diego Padres vs Arizona Diamondbacks Prediction & Betting Tips for 9/28/2025

Want our best San Diego Padres vs Arizona Diamondbacks prediction for 9/28/25? Get our MLB betting tip as the Diamondbacks travel to the Padres on 9/28/25 at PETCO Park, in San Diego. Knup Sports has your free pick!

The Arizona Diamondbacks, with a record of 80-81, look to break their four-game losing streak as they take on the San Diego Padres. Under the leadership of manager Torey Lovullo, the Diamondbacks have struggled recently, going 4-6 in their last ten games. With a road record of 37-43, they face a challenging game at PETCO Park.

The San Diego Padres, sitting second in the NL West with a record of 89-72, have been on a positive run. Managed by Mike Schildt, the Padres have won their last two games and are 7-3 in their recent ten outings. Their strong home record of 51-29 makes them tough opponents in San Diego.

This afternoon game on September 28, 2025, promises an interesting matchup at PETCO Park with mild weather conditions and scattered clouds. Recent meetings between these teams have seen the Padres dominate, including a 5-1 victory on September 27th. With the Diamondbacks seeking redemption, the stage is set for another compelling game.

Padres vs Diamondbacks At a Glance

  • Game Location: PETCO Park in San Diego, CA
  • Weather Conditions: Mild with scattered clouds and calm winds
  • Broadcast Info: Available on TV channel ARID
  • Padres Recent Performance: Record stands at 89-72 with a winning streak of 2 games
  • Diamondbacks Recent Performance: Record of 80-81 and currently on a 4-game losing streak
  • Betting Odds: Padres Moneyline at -114, Diamondbacks at -107

Padres Ready to Close Out Season Strong Against Diamondbacks

Diamondbacks’ Offensive Overview

The Arizona Diamondbacks enter the game with a batting average of .252, ranking 6th in the league. Their on-base percentage is .318, placing them 11th overall. While they have a modest slugging percentage of .389, they struggle in the power department, ranking 26th in home runs with 151.

Despite the low home run tally, the Diamondbacks have shown consistency with doubles, where they rank 14th in the league. Their patience at the plate is evident in their 506 walks, which places them 15th. However, they also have a high strikeout rate, ranking 3rd with 1152 strikeouts.

Key Players to Watch

Brandon Pfaadt will take the mound for the Diamondbacks, bringing his 13-8 record and 5.00 ERA. His WHIP stands at 1.33, indicating some challenges with base runners. Pfaadt will need to manage the Padres’ potent offense carefully.

Offensively, Arizona’s standout performer has been Geraldo Perdomo, who recently hit his 20th home run. Perdomo’s current on-base streak is a career-best 16 games, showcasing his ability to consistently reach base.

Diamondbacks’ Pitching Insights

The Diamondbacks’ pitching staff has an ERA of 3.64, ranking them 3rd in the league. Their pitchers have been particularly effective at limiting opponents’ batting average, holding teams to a .224 average, which is the best in the league.

Despite their success in limiting hits, Arizona’s staff has given up 177 home runs, placing them 11th. With 48 quality starts, they rank 16th, and they lead the league in blown saves with only 16, highlighting the reliability of their bullpen.

Betting Trends for the Diamondbacks

  • Overall Record: 82-80
  • Last 5 Games: 2-3
  • Against Division Opponents: 34-36
  • As Underdog: 30-38
  • In Away Games: 40-41
  • Runline (ATS) Overall: 79-83
  • O/U in Away Games: 38-43

Game Strategy Considerations

Arizona will likely rely on Pfaadt to keep the game close early, allowing their bullpen to maintain the lead if possible. The Diamondbacks’ approach will be to capitalize on any mistakes made by Padres’ starter JP Sears, who holds an ERA of 5.12.

For Arizona, generating offense against the Padres’ strong pitching staff will be crucial. They will need to leverage their patience at the plate to draw walks and put pressure on Sears and the Padres’ bullpen throughout the game.

Diamondbacks Seek Redemption in Crucial Showdown

Team Overview

The Arizona Diamondbacks have struggled in their recent outings, dropping their last four games. With a season record just below .500, they will aim to end on a high note against the San Diego Padres. Their offensive lineup ranks well in slugging percentage at 3rd in the league, but they have faced challenges in maintaining consistency.

Key Hitters

Geraldo Perdomo has been a standout player for the Diamondbacks, boasting a .291 batting average with 20 home runs. His ability to get on base and drive in runs has been crucial for Arizona, as he’s achieved his first career season with at least 20 home runs and 20 stolen bases.

Ketel Marte provides additional firepower with a .283 average and 27 home runs. He ranks 1st on the team in home runs and serves as a vital piece in their offensive setup.

Pitching Concerns

Brandon Pfaadt will start on the mound for the Diamondbacks, entering the game with a 5.00 ERA and a 13-8 record. His performance will be critical as the Diamondbacks aim to prevent a series sweep against the Padres.

The Diamondbacks’ bullpen has seen its struggles, with Eduardo Rodriguez’s recent outing highlighting issues. In his last start, Rodriguez allowed six earned runs, impacting the team’s ability to stay competitive.

Injury Impact

The Diamondbacks have faced numerous injuries, with key players like Corbin Burnes and A.J. Puk out for the season. These absences have significantly affected the team’s depth, particularly in the pitching department.

Pavin Smith is also out due to a strained left quad, and Blaze Alexander is day-to-day with a wrist injury. These injuries have forced Arizona to adapt and rely on their bench players.

Betting Trends

  • SU in Away Games: 37-43 (46.2%)
  • Runline as Underdog: 46-26 (63.9%)
  • O/U in Away Games: 40-40 (50.0%)
  • SU After a Loss: 35-45 (43.8%)
  • Runline After a Loss: 36-44 (45.0%)

Padres vs Diamondbacks Prediction: Padres -114

The San Diego Padres come into this game with a robust home record of 51-29, and they have been dominant against the Diamondbacks recently, winning the last three games by an average margin of 2.7 runs. They have also secured victories in six of their last seven games, indicating strong current form as they head into this matchup. These factors, combined with their superior division record and recent performances against Arizona, make them a favorable choice at odds of -114.

Arizona’s pitcher, Brandon Pfaadt, holds a 5.00 ERA, and while he has managed a winning record, the Padres have already proven they can handle his pitching, as seen in previous encounters. Meanwhile, Padres starter JP Sears has struggled with an ERA of 5.12, yet the Padres’ offense has consistently provided ample support, as highlighted by their recent 5-1 win against Arizona. This pattern suggests that even with Sears on the mound, San Diego should be able to secure the win.

The Diamondbacks are on a four-game losing streak and have struggled on the road this season, with a record of 37-43. Their recent form, coupled with their inability to capitalize on scoring opportunities, as seen in the previous games against the Padres, further supports choosing San Diego. Additionally, the Padres are motivated to complete the series sweep at home, adding psychological advantage to their physical performance.

Given these dynamics, the projected final score for this game is Padres 6 – Diamondbacks 3, with the Padres’ powerful lineup expected to outmatch Arizona’s pitching and offensive output once again. The Padres are in a strong position to not only finish the regular season on a high note but also to carry their momentum into the postseason.

  • Padres vs Diamondbacks Prediction: Padres -114
  • Padres vs Diamondbacks Score: Padres 6 – Diamondbacks 3
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