The San Francisco 49ers head to SoFi Stadium to take on the Los Angeles Rams in a pivotal NFC West game. Both teams enter Week 5 of the 2025 season with a 3-1 record, showcasing impressive performances thus far. The game kicks off on Thursday, October 2, 2025, at 8:15 PM, and will be broadcast on AMZN. San Francisco is coming off a narrow home loss to the Jacksonville Jaguars, 26-21, despite a strong offensive performance featuring 306 passing yards. Under the leadership of head coach Kyle Shanahan, the 49ers have a perfect road record this season at 2-0. They’ll look to maintain that momentum against a strong Rams team in their division. The Los Angeles Rams, led by head coach Sean McVay, secured a home victory against the Indianapolis Colts, 27-20, in their last outing. The Rams have been dominant at home this season with a 2-0 record at SoFi Stadium. As favorites with a -6.5 spread, the Rams will aim to leverage their home advantage once again.
Rams vs 49ers At a Glance
- Game Date and Time: Thursday, October 2, 2025 at 8:15 PM (Night Game)
- Location: SoFi Stadium in Inglewood, CA USA — Dome
- 49ers Record: 3-1-0 for the season
- Rams Record: 3-1-0 for the season
- Weather Forecast: Clear Sky and warm day with a light breeze
- Game Broadcast: Available on AMZN
The Los Angeles Rams: A Season of Promise and Potential
Offensive Capabilities
The Los Angeles Rams have demonstrated a robust offensive performance this season. Ranked 10th in passing yards with 3,868 yards, their aerial attack is a key component of their strategy. However, their rushing game ranks 23rd with 1,765 yards, indicating room for improvement on the ground.
Quarterback Matthew Stafford has been a standout performer, amassing 1,114 passing yards, placing him 1st in the team and 2nd in the league. With 8 passing touchdowns, Stafford is pivotal to the Rams’ offensive success.
Defensive Strengths
On the defensive front, the Rams rank 11th in sacks with 38, showing their ability to pressure opposing quarterbacks. Their pass defense is also effective, ranking 7th with 13 interceptions.
While they excel in certain defensive areas, the Rams have allowed 5,998 opponent yards, ranking 26th. This suggests a need to tighten up their overall defensive strategy.
Recent Performances
The Rams have shown mixed results in recent games. Their 27-20 victory over the Indianapolis Colts highlighted their offensive prowess, particularly through the air with 360 passing yards.
Conversely, their 33-26 loss to the Philadelphia Eagles exposed some vulnerabilities, despite a strong rushing performance of 160 yards. Consistency remains a focus as they move forward.
Key Players and Injuries
Puka Nacua has emerged as a leading receiver, recording 503 yards and ranking 1st in the league. His performance is a significant asset for the Rams’ passing game.
The Rams face some injury challenges, with Rob Havenstein and Tyler Higbee questionable for their next game. Ahkello Witherspoon is out, impacting their defensive depth.
Betting Trends
- SU – As Favorite (REG): 7-0 (100.0%)
- ATS – As Favorite (REG): 7-0 (100.0%)
- SU – After Loss (REG): 4-0 (100.0%)
- ATS – After Loss (REG): 4-0 (100.0%)
- O/U – After Win (REG): 3-0 (100.0%)
San Francisco 49ers Set to Challenge the Rams: An In-depth Analysis
Offensive Performance
The San Francisco 49ers have shown strength in their passing game, ranking 4th in the league with 4,234 passing yards last season. Brock Purdy and Mac Jones have both contributed significantly, with Purdy leading the team in passing yards. However, the 49ers’ rushing attack ranked 12th, indicating a balanced offensive strategy.
Christian McCaffrey has been a crucial part of the 49ers’ offense, leading the team in rushing yards. Despite not finding the end zone on the ground, his ability as a dual-threat back has been evident, ranking 1st in receptions and receiving yards among running backs.
Defensive Challenges
On the defensive front, the 49ers face some challenges, ranking 26th in opponent scoring last season. However, they have been effective in applying pressure with 37 sacks, ranking 12th in the league.
With key injuries affecting players like Nick Bosa and Kevin Givens, the 49ers will need other defensive players to step up. Fred Warner and Dee Winters have been standout performers, contributing significantly in tackles.
Recent Game Recaps
In their recent game against the Jacksonville Jaguars, the 49ers lost 26-21. Despite a strong passing performance with 306 yards, turnovers proved costly, with two interceptions and three fumbles.
In contrast, the 49ers secured a narrow 16-15 victory against the Arizona Cardinals, showcasing their resilience. They limited the Cardinals to just 154 passing yards, highlighting their defensive potential.
Injury Concerns
The 49ers’ injury report lists several key players, including George Kittle and Nick Bosa, on the injured reserve list. Their absence will require adjustments in both offensive and defensive strategies.
Jauan Jennings, Brock Purdy, and Ricky Pearsall are listed as questionable, further complicating the team’s depth. The 49ers will need to rely on their depth chart to compensate for these potential absences.
Team Betting Trends
- O/U – After Loss (REG): Last 8 REG Games (2024–2025) → 6-2 (75.0%)
- O/U – All Games (REG): Last 7 REG Games (2024–2025) → 5-2 (71.4%)
- SU – All Games (REG): Last 4 REG Games (2025) → 3-1 (75.0%)
- SU – As Favorite (REG): Last 4 REG Games (2025) → 3-1 (75.0%)
- O/U – As Underdog (REG): Last 4 REG Games (2024) → 3-1 (75.0%)
- O/U – Away Games (REG): Last 4 REG Games (2024–2025) → 3-1 (75.0%)
- ATS – As Favorite (REG): Last 10 REG Games (2024–2025) → 6-4 (60.0%)
- O/U – As Favorite (REG): Last 3 REG Games (2025) → 2-1 (66.7%)
- O/U – Home Games (REG): Last 3 REG Games (2024–2025) → 2-1 (66.7%)
- SU – Away Games (REG): Last 3 REG Games (2024–2025) → 2-1 (66.7%)
- ATS – Away Games (REG): Last 3 REG Games (2024–2025) → 2-1 (66.7%)
- SU – After Win (REG): Last 3 REG Games (2025) → 2-1 (66.7%)
- O/U – After Win (REG): Last 3 REG Games (2025) → 2-1 (66.7%)
- ATS – After Win (REG): Last 6 REG Games (2024–2025) → 3-3 (50.0%)
- ATS – All Games (REG): Last 14 REG Games (2024–2025) → 6-8 (42.9%)
- SU – Home Games (REG): Last 7 REG Games (2024–2025) → 3-4 (42.9%)
- ATS – Home Games (REG): Last 7 REG Games (2024–2025) → 3-4 (42.9%)
- SU – After Loss (REG): Last 8 REG Games (2024–2025) → 3-5 (37.5%)
- ATS – After Loss (REG): Last 8 REG Games (2024–2025) → 3-5 (37.5%)
- SU – As Underdog (REG): Last 3 REG Games (2024) → 0-3 (0.0%)
Rams vs 49ers Prediction: Over 46.5
The Los Angeles Rams and San Francisco 49ers both enter this game with a 3-1 record, indicating strong performances on both sides. The Rams have been impressive at home with a 2-0 record, and the 49ers are undefeated on the road with a 2-0 record. Given these strong showings, both teams are expected to put up significant points on the board.
Looking at their offensive stats from the last season, the 49ers ranked 13th in scoring and 4th in passing yards, while the Rams ranked 19th in scoring but had a top 10 passing offense. This suggests that both teams have the capability to produce high-scoring games, especially in favorable conditions at the SoFi Stadium dome.
In their previous matchups, the Rams and 49ers have had several high-scoring encounters, with three of their last four games going over the set total. For instance, a 27-24 outcome in their last meeting at SoFi Stadium suggests the trend could continue. This history of high scores aligns well with the current total set at 46.5 points.
Considering these factors, the pick for this game is the over. Both teams possess potent offenses capable of exploiting each other’s defenses, and with their recent head-to-head history, a high-scoring game seems likely. The projected final score supports this with the Rams edging out the 49ers 28-24.
- Rams vs 49ers Prediction: Over 46.5
- Rams vs 49ers Score: Rams 28 – 49ers 24
