CFB Game Prediction

Purdue vs USC Prediction & Betting Tips for CFB Week 3 on 9/13/2025

Want our best Purdue vs USC prediction for 9/13/25? Get our College Football betting tip as the USC travel to Purdue in Week 3 on 9/13/25 at Ross-Ade Stadium, in Purdue. Knup Sports has your free CFB pick!

In Week 3 of the 2025 College Football regular season, the USC Trojans travel to Ross-Ade Stadium to take on the Purdue Boilermakers. Both teams are undefeated so far with a 2-0 record. The game, set for Saturday, September 13, 2025, at 3:30 PM, will be broadcast on CBS. USC has dominated their opening games, outscoring opponents with a significant margin. Their recent victory against Georgia Southern ended with a commanding 59-20 scoreline. Although the Trojans have yet to play an away game this season, their offensive strength has been evident. Purdue has also started their season strong, securing wins against Southern Illinois and Ball State. The Boilermakers are looking to leverage their home advantage at Ross-Ade Stadium. With both teams yet to play a conference game, this matchup might set the tone for their respective seasons in the Big Ten.

Purdue vs USC At a Glance

  • Game Date and Time: Saturday, September 13, 2025 at 3:30 PM
  • Location: Ross-Ade Stadium in West Lafayette, IN
  • TV Broadcast: CBS
  • USC Trojans Record: 2-0 this season
  • Purdue Boilermakers Record: 2-0 this season
  • Game Odds: USC is favored with a -21.0 spread

Purdue Boilermakers Ready to Maintain Winning Momentum

Offensive Performance

Purdue’s offense has shown a notable improvement this season, scoring 65 points over the first two games, ranking them 29th in the nation. They have accumulated 510 passing yards, placing them 45th, and 310 rushing yards, ranking 68th. Their 52 first downs rank an impressive 12th, highlighting their ability to sustain drives.

Ryan Browne, Purdue’s quarterback, has been pivotal, accumulating 481 passing yards and four touchdowns in just two games. His performance ranks 43rd nationally in passing yards. The Boilermakers’ offensive line has done a commendable job, providing Browne the protection he needs.

Defensive Strength

The Boilermakers’ defense has been a force to reckon with, allowing just 17 points over two games, ranking them 9th nationally. Their pass rush has been especially effective, recording seven sacks, placing them 4th in the nation. Despite not having any interceptions, their defensive front has ensured opponents struggle to gain ground.

Purdue’s defense has shown resilience in stopping the run, evident in their last game against Southern Illinois where they restricted them to just 81 rushing yards. The defensive unit’s ability to recover from last year’s struggles, where they allowed 479 points, has been remarkable.

Key Players to Watch

Running back Devin Mockobee has been a standout performer, rushing for 185 yards and three touchdowns, ranking him 36th nationally in rushing yards. His dual-threat capability is further highlighted by his four receptions for 66 yards. Arhmad Branch, the leading wide receiver, has amassed 132 receiving yards and two touchdowns.

On special teams, kicker Spencer Porath has been reliable, converting three field goals and all eight extra-point attempts. His contributions have added to Purdue’s scoring depth, making them a well-rounded team in all aspects.

Injury Concerns

Purdue has some injury concerns, with key players like Chauncey Magwood and De’Nylon Morrissette listed as questionable. Their absence could impact the passing game, although Purdue’s depth has been evident this season. The team will hope for a speedy recovery to maintain their offensive momentum.

Betting Trends

  • SU Last 3: 2-0 (100.0%)
  • SU Last 5: 2-0 (100.0%)
  • SU All Games: 2-0 (100.0%)
  • ATS Last 3: 2-0 (100.0%)
  • ATS All Games: 2-0 (100.0%)
  • O/U Last 3: 0-2 (0.0%)
  • O/U All Games: 0-2 (0.0%)

USC Trojans Gear Up for an Exciting Showdown

Purdue Boilermakers: Offense Analysis

The Purdue Boilermakers are known for their dynamic offensive strategies. In recent seasons, they’ve shown a penchant for explosive plays that can catch defenses off guard. Their ability to adapt mid-game has been a strength, allowing them to adjust and find weaknesses in the opposition.

The Boilermakers’ passing game is particularly noteworthy, often ranking among the top in their conference. They rely heavily on their quarterback to lead the charge and distribute the ball effectively to a versatile receiving corps. This strategy keeps defenses guessing and can lead to high-scoring games.

Purdue Boilermakers: Defensive Insights

Defensively, Purdue has been working to shore up its vulnerabilities. While their defense has had moments of brilliance, consistency remains a challenge. They have been investing in their pass rush, aiming to disrupt opposing quarterbacks and force turnovers.

The secondary for the Boilermakers is a key area of focus, as they strive to improve their coverage against top-tier receivers. By tightening up this aspect, they hope to reduce the yardage allowed through the air and contain explosive plays.

Purdue Boilermakers: Key Players to Watch

One of the standout players for Purdue is their quarterback, who has been instrumental in orchestrating their offensive schemes. His ability to read defenses and make quick decisions is critical to their success. Additionally, the team’s leading receiver is known for his speed and ability to create separation.

On the defensive side, a linebacker has emerged as a leader, often rallying the team with his tenacity and tackling prowess. His ability to read the game and react swiftly makes him a crucial asset in stopping the run and defending against short passes.

Boilermakers’ Recent Performance

In recent games, Purdue has shown resilience and the ability to compete against strong teams. Their offense has been firing on all cylinders, putting up impressive numbers in both passing and rushing yards. However, maintaining momentum throughout the game is essential for them to secure victories.

Defensively, the Boilermakers have had mixed results, with moments of strong play interspersed with lapses. They will need to ensure that their defensive unit remains cohesive and focused to handle the offensive threats posed by USC.

Purdue Boilermakers Betting Trends

  • SU Last 3: Data not provided
  • SU All Games: Data not provided
  • ATS Last 3: Data not provided
  • ATS All Games: Data not provided
  • O/U Last 3: Data not provided
  • O/U All Games: Data not provided

Purdue vs USC Prediction: Purdue +21.0

As Purdue hosts USC at Ross-Ade Stadium, the Boilermakers come in with a perfect 2-0 record. Their solid performance against the spread (ATS) this season at home shows they are a team capable of competing closely. Given the +21 spread, backing Purdue seems like the right choice.

USC has been dominant, scoring 132 points in just two games, but this will be their first road test of the season. While they have shown offensive firepower, Purdue’s defense ranks 9th in points against, indicating they can contain high-powered offenses to some degree. This makes Purdue a strong candidate to cover the large spread.

Purdue’s offensive stats reveal they are 29th in points scored, which should help them keep pace with USC’s potent attack. With the game being held at home, the Boilermakers’ familiarity with their environment might provide an additional edge in keeping the game competitive.

Considering the data, Purdue’s ability to cover the spread looks promising. A projected final score of USC 38 – Purdue 20 supports the belief that Purdue can stay within the 21-point margin.

  • Purdue vs USC Prediction: Purdue +21.0
  • Purdue vs USC Score: USC 38 – Purdue 20
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