The Buffalo Bills will travel to Charlotte, NC, to face the Carolina Panthers at Bank of America Stadium in Week 8 of the 2025 NFL season. The game is scheduled for Sunday, October 26, 2025, at 1:00 PM and will be televised on FOX. Weather forecasts predict a cool day with overcast clouds, setting the stage for an exciting contest on the outdoor field. The Bills, under the guidance of head coach Sean McDermott, hold a 4-2 record this season. They are looking to bounce back after consecutive losses against the Atlanta Falcons and New England Patriots. With a road record of 1-1, the Bills aim to improve their standings in the AFC East. Carolina Panthers, led by head coach Dave Canales, have a 4-3 record and are undefeated at home with a 3-0 record. The Panthers recently secured a narrow win against the New York Jets, boosting their confidence ahead of this home game. With a division record of 1-0, the Panthers are keen to maintain their strong performance at Bank of America Stadium.
Panthers vs Bills At a Glance
- Location: Bank of America Stadium, Charlotte, NC
- Game Time: Sunday, October 26, 2025, at 1:00 PM
- Weather: Cool with overcast clouds
- TV Broadcast: FOX
- Buffalo Bills Record: 4-2-0
- Carolina Panthers Record: 4-3-0
Panthers Prowl: Carolina Panthers Aim to Continue Winning Streak
Offensive Overview
The Carolina Panthers offense has shown flashes of potential in the 2024 season, scoring a total of 341 points, ranking them 22nd in the league. Their passing game, however, struggles, with only 3188 yards and a rank of 30th. On the ground, they are more efficient, achieving 1878 rushing yards, placing them 18th.
First downs remain a challenge for the Panthers, as they ranked 29th with just 293 first downs. On third downs, they converted 36% of their attempts, positioning them at 22nd in the league. The offensive line needs to step up to maintain the momentum gained from recent victories.
Defensive Challenges
Defensively, the Panthers have allowed 534 points, ranking them 29th in points allowed. Despite this, they have managed to secure 32 sacks, which is a respectable 16th in the league. Their secondary is slightly better, with 9 interceptions, ranking them 11th.
Fumble recoveries are a bright spot for the Panthers, with 8 recoveries placing them 7th in the league. However, they have struggled overall in yardage, allowing 6877 opponent offensive yards, the worst in the NFL. Tightening up their defensive yardage will be crucial for upcoming games.
Recent Performance
The Panthers have been on a roll recently, winning three consecutive games. They edged out the New York Jets 13-6, and had a close 30-27 victory over the Dallas Cowboys. The offense was particularly effective against the Miami Dolphins, with a 27-24 win.
However, the team suffered a significant loss to the New England Patriots, with a score of 42-13. In their home game against the Atlanta Falcons, the Panthers dominated with a 30-0 shutout. These performances illustrate both their potential and areas needing improvement.
Key Players
Quarterback Bryce Young has been pivotal, throwing for 1288 yards and 11 touchdowns over seven games. Rico Dowdle leads the rushing attack with 551 yards, placing him 3rd in the league. Wide receiver Tetairoa McMillan has been Young’s primary target, with 413 receiving yards.
On defense, Derrick Brown and Tre’von Moehrig have been standout performers. Brown recorded 2 sacks in the recent game against the Jets. Moehrig’s consistent tackling and ability to make plays have been crucial for the Panthers’ defensive unit.
Team Betting Trends
- SU – Home Games (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
- ATS – Home Games (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
- SU – All Games (REG): Last 3 REG Games (2025) → 3-0 (100.0%)
- ATS – All Games (REG): Last 3 REG Games (2025) → 3-0 (100.0%)
- SU – As Underdog (REG): Last 3 REG Games (2025) → 3-0 (100.0%)
- ATS – As Underdog (REG): Last 3 REG Games (2025) → 3-0 (100.0%)
- ATS – After Loss (REG): Last 3 REG Games (2025) → 3-0 (100.0%)
Buffalo Bills Look to Shine Against the Panthers
Overview of Buffalo Bills Offense
The Buffalo Bills have been a powerhouse on offense this season, ranking 2nd in total score with 525 points. Their passing game, led by quarterback Josh Allen, has amassed 3,875 yards, placing them 9th in the league. Their rushing attack is equally impressive, ranked 9th with 2,230 yards.
With a 44.1% third down conversion rate, the Bills rank 7th, demonstrating their efficiency in crucial situations. Their ability to move the chains is evident, as they are 6th in the league with 360 first downs. This balanced attack makes the Bills a formidable opponent for any defense.
Buffalo Bills Defensive Strengths
Defensively, the Bills have been solid, allowing only 368 points, which ranks them 11th in the league. They have an effective pass rush, ranking 10th with 39 sacks. Their ability to create turnovers is highlighted by their league-leading 16 fumble recoveries.
Additionally, the Bills have 16 opponent interceptions, placing them 4th in the league. They have allowed 5,806 opponent offensive yards, ranking them 17th. The defense’s capability to stifle offenses is a key component of the team’s success.
Recent Performance and Key Players
In recent games, the Bills have seen mixed results, with a win over the New Orleans Saints (31-19) and losses to the Atlanta Falcons (24-14) and New England Patriots (23-20). Josh Allen remains a pivotal player, delivering 1,397 passing yards and 11 touchdowns this season. Running back James Cook has also contributed significantly, rushing for 537 yards and scoring five touchdowns.
Despite some injuries, key players like Dalton Kincaid and Khalil Shakir have stepped up in the receiving department. Kincaid has recorded 287 receiving yards and three touchdowns, while Shakir has accumulated 268 yards and two touchdowns. These players are crucial to the Bills’ offensive dynamics.
Injury Concerns
The Bills face a challenging injury report, with key players like DaQuan Jones, Matt Milano, and Curtis Samuel listed as questionable. Additionally, players like Cameron Johnston and Gabe Davis are on the injured reserve list, affecting their depth. The team’s ability to manage these injuries will be vital in maintaining their performance levels.
Buffalo Bills Betting Trends
- SU – Home Games (REG): Last 9 REG Games (2024–2025) → 8-1 (88.9%)
- O/U – Totals ≥ 50 (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
- SU – Totals ≥ 50 (REG): Last 3 REG Games (2024–2025) → 3-0 (100.0%)
- SU – All Games (REG): Last 15 REG Games (2024–2025) → 11-4 (73.3%)
- ATS – All Games (REG): Last 15 REG Games (2024–2025) → 10-5 (66.7%)
- O/U – All Games (REG): Last 15 REG Games (2024–2025) → 10-5 (66.7%)
- ATS – Away Games (REG): Last 6 REG Games (2024–2025) → 4-2 (66.7%)
Panthers vs Bills Prediction: Panthers +7.5
The Carolina Panthers have proven to be a strong force at home this season with an undefeated record of 3-0. Their recent trends suggest they are a reliable pick against the spread, particularly as underdogs, boasting a 3-0 ATS record in their last three games. With a solid home performance history, the Panthers have a strong case for covering the +7.5 spread.
Buffalo Bills, while having an impressive 4-2 overall record, have shown vulnerabilities on the road with a 1-1 record. The Panthers, on the other hand, have been consistent at home, winning their last four games outright, which adds confidence in their ability to keep the game close. The Bills are coming off two straight losses, further supporting the Panthers’ potential to cover the spread.
The Panthers have demonstrated their ability to perform well as underdogs, making them an attractive pick for bettors. Their recent head-to-head history against the Bills in preseason has seen them cover the spread, indicating that they can compete closely with Buffalo. The spread of +7.5 gives Carolina a favorable chance to either win or at least keep the game within a touchdown.
Given the Panthers’ strong home performance and the Bills’ recent struggles, this game could be closer than the odds suggest. A projected final score of Panthers 24 – Bills 21 aligns with Carolina covering the +7.5 spread, making them the pick for this matchup.
- Panthers vs Bills Prediction: Panthers +7.5
- Panthers vs Bills Score: Panthers 24 – Bills 21
