CFB Game Prediction

North Carolina vs Clemson Prediction & Betting Tips for CFB Week 6 on 10/4/2025

Want our best North Carolina vs Clemson prediction for 10/4/25? Get our College Football betting tip as the Clemson travel to North Carolina in Week 6 on 10/4/25 at Kenan Stadium, in North Carolina. Knup Sports has your free CFB pick!

In Week 6 of the 2025 College Football Regular Season, the Clemson Tigers travel to face the North Carolina Tar Heels at Kenan Stadium in Chapel Hill, NC. The game is set for Saturday, October 4, 2025, with a kickoff time of 12:00 PM and will be broadcast on ESPN. Both teams are looking to improve their standing within the Atlantic Coast Conference. Clemson enters this game with a 1-3 record, struggling in conference play at 0-2. They have yet to secure a road victory this season, holding a 0-1 record away from Memorial Stadium. Clemson’s recent performance includes a 34-21 home loss to Syracuse and a narrow 24-21 road loss to Georgia Tech, highlighting challenges on both sides of the ball. North Carolina, holding a 2-2 record, seeks redemption after a 34-9 defeat against UCF in their last outing. The Tar Heels have split their home games this season, posting a 1-1 record at Kenan Stadium. Their offense aims to regain momentum following their earlier 41-6 victory over Richmond, as they face a Clemson team eager for a turnaround.

North Carolina vs Clemson At a Glance

  • Game Location: Kenan Stadium in Chapel Hill, NC
  • Broadcast Channel: ESPN
  • Game Start Time: Saturday, October 4, 2025 at 12:00 PM
  • Clemson Moneyline Odds: -610
  • North Carolina Moneyline Odds: +438
  • Weather Forecast: Outdoor game, check local weather for updates

North Carolina Tar Heels Gear Up for a Showdown

Offensive Struggles

The North Carolina Tar Heels have been experiencing some difficulties on offense this season. Currently ranked 77th in points for, they’ve accumulated only 84 points so far. Their passing game has also been underwhelming, with just 600 passing yards, placing them 124th in the nation.

On the ground, the Tar Heels have mustered 457 rushing yards, which is ranked 116th. This offense needs to find its rhythm to challenge their upcoming opponents effectively. Their 55 first downs indicate the struggle to sustain drives.

Defensive Performance

Defensively, the Tar Heels rank 59th in points against, having allowed 91 points this season. Despite the high number of points given up, they have been effective in pressuring opposing quarterbacks, recording 4 sacks and ranking 17th.

Their secondary has been impressive, intercepting the ball 4 times, ranking 5th nationally. They have also demonstrated an ability to force fumbles, recovering 2 of them, placing them again at the 5th spot.

Recent Game Insights

The Tar Heels had a challenging game against the UCF Knights, suffering a 34-9 defeat. They struggled to gain momentum, achieving only 14 first downs compared to UCF’s 23.

North Carolina’s passing game was limited to 154 yards, and their rushing game wasn’t much better with just 65 yards. Turnovers were costly, with two interceptions contributing to their loss.

Key Players to Watch

Gio Lopez has been the standout quarterback for the Tar Heels, playing in all four games and accumulating 430 passing yards. His leadership will be critical as the team looks to improve offensively.

In the backfield, Demon June has shown promise with 250 rushing yards over three games. The receiving corps is led by Jordan Shipp, who has 193 receiving yards and 2 touchdowns in four games.

Betting Trends

  • O/U – Totals ≥ 50: Last 3 Games (2024–2025) → 3-0 (100.0%)
  • SU – After Win: Last 25 Games (2022–2025) → 18-7 (72.0%)
  • SU – As Favorite: Last 28 Games (2022–2025) → 19-9 (67.9%)
  • SU – Home Games: Last 30 Games (2021–2025) → 19-11 (63.3%)
  • SU – After Loss: Last 24 Games (2020–2025) → 15-9 (62.5%)

The Clemson Tigers: Analyzing Their Performance Ahead of the Upcoming Game

Offensive Struggles

The Clemson Tigers have found it challenging to maintain offensive consistency this season. They rank 81st in points scored, totaling only 79 points in the 2025 regular season so far. Despite their 74th ranking in passing yards with 996 yards, their rushing attack has been a significant concern, positioned at 115th with only 466 yards.

In their recent loss to Syracuse, the Tigers demonstrated their passing capability with 363 yards but still couldn’t secure the win. Their rushing game was slightly more effective against Georgia Tech, with 174 rushing yards, but still fell short of expectations.

Defensive Strengths

Defensively, Clemson has shown remarkable capabilities, particularly in sacking the opposing quarterback. They have achieved 10 sacks, ranking 11th, and have been effective in forcing turnovers with 3 interceptions and 2 fumbles recovered, placing them 4th and 5th, respectively.

However, the Tigers have allowed 91 points against them, ranking 59th. In their recent outings, they struggled to contain the offensive threats of Syracuse and Georgia Tech, allowing 34 and 24 points, respectively.

Key Players

Cade Klubnik, Clemson’s quarterback, has been a standout with 996 passing yards, ranking 61st nationally. His performance in passing touchdowns is less impressive, with only 6 touchdowns ranking 64th. His interception count of 4 shows room for improvement in decision-making.

On the ground, Adam Randall has been the primary rushing threat with 338 yards over four games, but the rest of the rushing unit has struggled. In the receiving corps, Bryant Wesco Jr. has been a reliable target, leading with 389 receiving yards and 5 touchdowns.

Injury Concerns

Clemson faces several injury challenges, which could impact their upcoming game. Notably, key players like Armon Mason, Misun Kelley, and Jay Haynes are questionable, potentially affecting both offensive and defensive depth.

The absence of Jarvis Green due to foot surgery is a significant blow to their rushing attack. The team will need to rely on other players stepping up to fill these gaps.

Team Betting Trends

  • SU – Home Games: Last 30 Games (2021–2025) → 24-6 (80.0%)
  • SU – After Loss: Last 15 Games (2020–2025) → 13-2 (86.7%)
  • SU – Totals ≥ 50: Last 30 Games (2021–2025) → 23-7 (76.7%)
  • SU – As Favorite: Last 29 Games (2022–2025) → 20-9 (69.0%)
  • SU – All Games: Last 21 Games (2023–2025) → 15-6 (71.4%)
  • SU – Away Games: Last 28 Games (2020–2025) → 19-9 (67.9%)
  • ATS – After Loss: Last 12 Games (2021–2025) → 8-4 (66.7%)
  • O/U – After Loss: Last 6 Games (2023–2025) → 4-2 (66.7%)

North Carolina vs Clemson Prediction: Over 45.5

The upcoming game between North Carolina and Clemson presents a compelling case for an over on the total of 45.5. Both teams have shown the ability to put up points in previous seasons, with North Carolina scoring 84 points and Clemson scoring 79 so far this season. Despite their records, both offenses have the potential to break out given their respective strengths in past games.

Clemson has a strong passing game, accumulating 996 yards, ranking 74th nationally. This offensive capability, combined with North Carolina’s defensive vulnerabilities, suggests that Clemson can contribute significantly to the point total. Additionally, Clemson’s defense has allowed 91 points this season, indicating the potential for North Carolina to capitalize on scoring opportunities.

North Carolina, while struggling offensively this season, has historically performed well in high-scoring games, particularly when totals are set above 50. Their recent game trends show a 3-0 record for overs when the total is 50 or more. This suggests they can contribute to a higher-scoring affair when faced with defenses that provide opportunities.

Considering these factors, the prediction leans towards an over, expecting both teams to exceed the set total with a final score projection of Clemson 28 – North Carolina 20. Clemson’s offense should find success against North Carolina’s defense, while North Carolina should manage to keep pace enough to push the game over 45.5.

  • North Carolina vs Clemson Prediction: Over 45.5
  • North Carolina vs Clemson Score: Clemson 28 – North Carolina 20
To Top