MLB Game Prediction

New York Yankees vs Chicago White Sox Prediction & Betting Tips for 9/25/2025

Want our best New York Yankees vs Chicago White Sox prediction for 9/25/25? Get our MLB betting tip as the White Sox travel to the Yankees on 9/25/25 at Yankee Stadium, in New York. Knup Sports has your free pick!

The New York Yankees will host the Chicago White Sox at Yankee Stadium in an intriguing matchup on Thursday, September 25, 2025, at 7:05 PM. The Yankees, with a record of 90-68, lead the AL East division and are currently on a four-game winning streak. In contrast, the White Sox, struggling with a 58-100 record, are at the bottom of the AL Central, having lost their last four games.

Yankee Stadium’s outdoor field will be the stage for this night game, where weather conditions are expected to include moderate rain and a light crosswind. Despite the conditions, both teams will aim to put on a strong performance. The game will be broadcast on CHSN, offering fans a chance to catch the action live.

In their previous encounters, the Yankees have dominated the White Sox, including an 8-1 victory on September 24th. With the Yankees’ strong home record of 46-31 and the White Sox’s struggles on the road at 25-52, the odds heavily favor the Yankees. Betting odds show the Yankees at -304 on the moneyline, while the White Sox are at +247, highlighting the challenging task ahead for Chicago.

Yankees vs White Sox At a Glance

  • Game Location: Yankee Stadium in New York, NY, an outdoor venue.
  • Weather Conditions: Expect moderate rain with a light breeze crosswind.
  • Chicago White Sox Record: They stand at 58-100, placing 5th in the AL Central.
  • New York Yankees Record: With a 90-68 record, they lead the AL East.
  • Game Odds: Yankees are heavily favored with a moneyline of -304.
  • Broadcast Information: Tune in to CHSN to watch the game live.

Yankees Ready to Shine Against the White Sox

White Sox Offensive Overview

The Chicago White Sox enter this game with a lineup that has shown potential throughout the season. They have managed to maintain a competitive batting average, but their on-base percentage has been an area needing improvement.

Chicago ranks 9th in home runs this season, indicating they have power hitters who can change the game with a swing. However, their consistency in driving in runs has been a challenge.

Key Players to Watch

One of the standout players for the White Sox is outfielder Luis Robert Jr., who has been a consistent offensive threat. His ability to hit for power and average makes him a key player in the White Sox lineup.

Tim Anderson is another player to keep an eye on. His skills in getting on base and stealing bases can disrupt opposing defenses and create scoring opportunities for Chicago.

Pitching Matchup

The White Sox will rely on Davis Martin, who has posted a 4.03 ERA this season. His performance has been a mix of solid outings and some struggles, making consistency key for him in this game.

Martin’s ability to control the game and limit walks will be crucial against the Yankees’ powerful lineup. The White Sox will need him to keep the Yankees’ sluggers in check to stay competitive.

Team Betting Trends

  • SU in Away Games: 44-37 (54.3%)
  • Runline in Away Games: 35-46 (43.2%)
  • O/U in Away Games: 40-41 (49.4%)

Final Thoughts

The White Sox will need to capitalize on any scoring opportunities against a tough Yankees pitching staff. Their ability to execute in clutch situations will determine their success in this matchup.

With the Yankees having a strong home record, the White Sox must bring their A-game to overcome the challenges presented at Yankee Stadium.

White Sox Set to Tackle the Yankees: A Crucial Showdown in the Bronx

Team Overview

The Chicago White Sox are heading into Yankee Stadium after a string of tough games, carrying a 58-100 record in the 2025 regular season. Their batting average stands at .232, ranked 18th in the league, but they face challenges with a slugging percentage of .371, ranked 25th.

The team has a total of 157 home runs, placing them 17th, and their on-base percentage is .300, ranked 20th. As they face the Yankees, they look to improve on these offensive metrics.

Key Players to Watch

Miguel Vargas, playing third base, brings a batting average of .231 with 15 home runs and 57 RBIs over 135 games. Lenyn Sosa, the team’s leading hitter, boasts a .259 average with 21 home runs, making him a vital component of their offense.

Chase Meidroth, covering shortstop, holds a .260 average, contributing with 5 home runs and 23 RBIs in 118 games. These players will need to step up to challenge the Yankees’ pitching.

Pitching Matchup

The White Sox will rely on Davis Martin to start, who holds an ERA of 4.03 and a WHIP of 1.27 with a 7-10 record. Facing him on the mound is Carlos Rodón for the Yankees, with an impressive ERA of 3.04.

Martin’s performance could be pivotal in this game, as the White Sox aim to stifle the Yankees’ potent offense. His ability to control the game will be a determining factor.

Betting Trends

  • Straight Up Last 10 Games: 1-9 (10.0%)
  • Runline All Games: 92-66 (58.2%)
  • O/U All Games: 73-85 (46.2%)
  • Runline vs League Opponents: 38-23 (62.3%)
  • O/U in Away Games: 31-46 (40.3%)

Challenges Ahead

The White Sox face a challenging road ahead with several key players on the injured list, including Martín Pérez and Andrew Benintendi. This has undoubtedly affected their performance and depth throughout the season.

The team has struggled in recent games, with only one win in their last ten outings, which underscores the difficulty they’ve faced. Their ability to adapt and overcome these challenges will be essential.

Yankees vs White Sox Prediction: Under 8.5

The matchup between the New York Yankees and the Chicago White Sox features a struggling White Sox offense that has found it difficult to score, given their 1-9 record in the last 10 games. Their road record of 25-52 further highlights their offensive struggles when away from home.

With Carlos Rodón on the mound for the Yankees, boasting an ERA of 3.04 and a WHIP of 1.06, the Yankees’ pitching is expected to keep the White Sox bats in check. Rodón’s impressive season stats suggest that he can limit the run production from the opposition effectively.

The weather conditions, described as ‘Moderate Rain’ with a light breeze, might also impact the game’s offensive output. Such conditions can make it challenging for hitters to maintain consistency and power at the plate.

Considering these factors and the recent 8-1 game where the Yankees dominated, the expectation is for a low-scoring game, resulting in the score remaining under 8.5. A projected final score of Yankees 5 – White Sox 1 supports this pick.

  • Yankees vs White Sox Prediction: Under 8.5
  • Yankees vs White Sox Score: Yankees 5 – White Sox 1
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