CFB Game Prediction

LSU vs Southeastern Louisiana Prediction & Betting Tips for CFB Week 4 on 9/20/2025

Want our best LSU vs Southeastern Louisiana prediction for 9/20/25? Get our College Football betting tip as the Southeastern Louisiana travel to LSU in Week 4 on 9/20/25 at Tiger Stadium (LA), in LSU. Knup Sports has your free CFB pick!

As Week 4 of the 2025 regular season unfolds, the Southeastern Louisiana Lions will travel to Baton Rouge to play against the LSU Tigers at Tiger Stadium. This Saturday night game is set to begin at 7:45 PM and will be broadcast on the SECN channel. The Lions, who are currently sitting with a 0-1 record, look to bounce back after their initial loss to Louisiana Tech. On the other side of the field, the LSU Tigers come into this game with an undefeated record of 3-0. Ranked third in the AP Poll and fourth in the Coaches Poll, LSU has shown their strength, particularly in their recent victories over Florida and Louisiana Tech at home. Tiger Stadium in Baton Rouge has been a fortress for them, as they have maintained a perfect home record this season. When looking at the odds, LSU is favored with a 39.5-point spread. Meanwhile, the Lions have had a challenging start, losing 24-0 to Louisiana Tech despite outperforming them in first downs and passing yards. The stage is set for an intriguing game under the lights at Tiger Stadium.

LSU vs Southeastern Louisiana At a Glance

  • Game Timing: Saturday, September 20, 2025, at 7:45 PM
  • Venue: Tiger Stadium (LA), Baton Rouge, LA
  • TV Channel: SECN
  • LSU Tigers Record: 3-0
  • Southeastern Louisiana Lions Record: 0-1
  • Point Spread: LSU -39.5 (-110), Southeastern Louisiana +39.5 (-110)

LSU Tigers Roar into Action for Upcoming Game

Offensive Strengths

The LSU Tigers have demonstrated a solid offensive lineup this season. Their passing game is notably strong, ranking 56th in the nation with 703 yards. Although their rushing yards rank lower at 103rd with 341 yards, their balanced attack keeps defenses on their toes.

Garrett Nussmeier has been leading the charge at quarterback, with 687 passing yards over three games, ranking 50th nationally. His ability to distribute the ball effectively has been key to LSU’s offensive success so far this season.

Defensive Prowess

On the defensive side, LSU has shown impressive capabilities. They rank 13th in the nation for points against, allowing only 27 points over their games.

The Tigers’ ability to apply pressure on opposing quarterbacks is evident, with seven sacks ranking them 8th nationally. Additionally, their secondary has been opportunistic, snagging six interceptions, which ties them for 7th in the nation.

Recent Performances

LSU’s recent games have highlighted their ability to win in various ways. In their latest outing, they secured a 20-10 victory against the Florida Gators, showcasing their defensive strength by limiting Florida to just 10 points.

Earlier, they took down Louisiana Tech Bulldogs 23-7, demonstrating their offensive potential with a robust performance both in the air and on the ground. This versatility has been a significant factor in their successful start to the season.

Key Players to Watch

Aside from Nussmeier, the running back duo of Caden Durham and Harlem Berry has been crucial for LSU’s ground game. Durham, in particular, has accumulated 196 rushing yards and two touchdowns over three games.

Aaron Anderson has been a reliable target in the receiving corps, with 247 receiving yards and 18 receptions. His presence on the field provides Nussmeier with a consistent option in the passing game.

Team Betting Trends

  • SU – Home Games: Last 25 Games (2021–2025) → 23-2 (92.0%)
  • SU – As Favorite: Last 29 Games (2022–2025) → 24-5 (82.8%)
  • SU – After Win: Last 28 Games (2022–2025) → 22-6 (78.6%)
  • SU – All Games: Last 5 Games (2024–2025) → 5-0 (100.0%)
  • SU – Totals ≥ 50: Last 29 Games (2022–2025) → 21-8 (72.4%)
  • ATS – Home Games: Last 24 Games (2021–2025) → 17-7 (70.8%)

Southeastern Louisiana Lions: Analyzing Their Upcoming Challenge

Offensive Struggles

The Southeastern Louisiana Lions have found it difficult to generate points in the 2025 season. They have not scored any points so far, placing them 100th in the nation for points per game. Their passing offense has also struggled, ranking 175th with only 145 passing yards.

Rushing the ball has been slightly better but still lacks effectiveness, ranking 145th with 126 yards. Despite their offensive woes, the Lions managed to secure 18 first downs, which ranks them 64th. This indicates that they can move the chains but have difficulty converting opportunities into points.

Defensive Overview

On the defensive side, the Lions have shown promise by allowing only 24 points, ranking them 10th nationally in points allowed. They have also managed to record three sacks, placing them 12th in that category. However, their turnover creation has been lacking, with zero interceptions or fumbles recovered.

The Lions’ defense will need to step up in forcing turnovers to help the offense with better field position. If they can maintain their current level of defensive performance, they may be able to keep games competitive.

Recent Performance

In their most recent outing, Southeastern Louisiana fell to Louisiana Tech by a score of 24-0. Despite having more first downs and passing yards, turnovers proved costly for the Lions. The two interceptions and two fumbles hindered their scoring opportunities and ultimately led to their defeat.

Going forward, reducing turnovers will be critical for the Lions to stay competitive in future games. Capitalizing on their ability to move the ball downfield will be key in turning potential scoring drives into actual points.

Key Players to Watch

Carson Camp leads the quarterback position with 122 passing yards, ranking 212th nationally. His performance will be crucial as the Lions look to establish a more effective aerial attack. Additionally, Jaedon Henry has shown potential in the running game with 31 rushing yards.

On the receiving end, Luke Besh has emerged as a target with 59 receiving yards. His ability to create plays will be vital in opening up the offense and providing options for the quarterbacks.

Team Betting Trends

  • ATS – All Games: Last 8 Games → 2-6 (25.0%)
  • ATS – As Underdog: Last 8 Games → 2-6 (25.0%)
  • ATS – Away Games: Last 8 Games → 2-6 (25.0%)
  • ATS – Totals ≥ 50: Last 8 Games → 2-6 (25.0%)
  • ATS – After Loss: Last 4 Games → 1-3 (25.0%)
  • O/U – All Games: Last 8 Games → 1-7 (12.5%)
  • O/U – As Underdog: Last 8 Games → 1-7 (12.5%)
  • O/U – Away Games: Last 8 Games → 1-7 (12.5%)
  • O/U – Totals ≥ 50: Last 8 Games → 1-7 (12.5%)
  • SU – All Games: Last 3 Games → 0-3 (0.0%)
  • SU – As Underdog: Last 3 Games → 0-3 (0.0%)
  • SU – Away Games: Last 3 Games → 0-3 (0.0%)
  • SU – After Loss: Last 3 Games → 0-3 (0.0%)
  • O/U – After Loss: Last 3 Games → 0-3 (0.0%)
  • SU – Totals ≥ 50: Last 3 Games → 0-3 (0.0%)

LSU vs Southeastern Louisiana Prediction: LSU -39.5

LSU enters this game with a strong 3-0 start to the season and a remarkable home record of 23-2 in their last 25 games. Their impressive offensive stats, having put up 60 points and 703 passing yards so far, suggest they have the capability to cover the hefty spread of -39.5 against a Southeastern Louisiana team that has yet to score this season.

The LSU defense has also been formidable, allowing only 27 points through three games, while Southeastern Louisiana’s offense has struggled, ranking 175th in passing yards. This combination gives LSU the clear upper hand in terms of both offensive and defensive strength.

Southeastern Louisiana’s record and stats so far this season do not bode well for their chances of keeping this game close. The Lions have allowed 24 points in their single game and have failed to find the end zone, which likely means trouble against a top-ranked LSU team.

Given LSU’s home field advantage and their track record as favorites, expecting them to cover the -39.5 spread seems reasonable. Look for LSU to dominate on both sides of the ball and finish with a decisive victory.

  • LSU vs Southeastern Louisiana Prediction: LSU -39.5
  • LSU vs Southeastern Louisiana Score: LSU 49 – Southeastern Louisiana 3
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