MLB Game Prediction

Los Angeles Angels vs Houston Astros Prediction & Betting Tips for 9/26/2025

Want our best Los Angeles Angels vs Houston Astros prediction for 9/26/25? Get our MLB betting tip as the Astros travel to the Angels on 9/26/25 at Angel Stadium of Anaheim, in Los Angeles. Knup Sports has your free pick!

The Houston Astros, with a record of 85-74, are set to play against the Los Angeles Angels at Angel Stadium of Anaheim. The Astros, led by manager Joe Espada, hold the second position in the AL West division. Currently, they have a record of 4-6 over their last ten games, including a recent victory against the Athletics.

The Los Angeles Angels, managed by Ron Washington, enter the game with a 71-87 record and are positioned fifth in the same division. Having won just two of their last ten games, the Angels are eager to improve their home record of 38-39. Their recent win against the Kansas City Royals might provide a much-needed boost.

This game, scheduled for Friday, September 26, 2025, at 9:38 PM, will be broadcast on SCHN. The weather forecast for Anaheim, CA, predicts a mild day with a light breeze under ‘Broken Clouds’. Betting odds favor the Astros with a moneyline of -148, while the Angels are at +126.

Angels vs Astros At a Glance

  • Game Location: Angel Stadium of Anaheim, Anaheim, CA
  • Astros Record: 85-74, currently 2nd in AL West
  • Angels Record: 71-87, holding 5th place in AL West
  • Game Time: 9:38 PM on September 26, 2025
  • Broadcast Information: Available on SCHN
  • Weather Conditions: Mild with ‘Broken Clouds’

The Angels Take on the Astros: A Crucial Game Ahead

Astros Hitting Performance

The Houston Astros have been putting up impressive power numbers with 220 home runs, placing them 5th in the league. Their batting average sits at .226, which ranks them 20th, indicating some inconsistency at the plate. However, their ability to hit the long ball could be a deciding factor in this game.

Despite their power, the Astros have struggled to get on base consistently, with an on-base percentage of .298, ranking 23rd in the league. This lack of base runners could hinder their ability to capitalize on their home run capabilities.

Key Astros Players to Watch

One player to watch on the Astros is their first baseman, who has been a key contributor to their home run tally. His ability to hit for power will be crucial against the Angels’ pitching staff.

Additionally, their outfielder with speed on the base paths could create opportunities by putting pressure on the Angels’ defense. This player ranks 16th in stolen bases, showcasing his potential to turn a walk or single into a scoring chance.

Astros Pitching Challenges

The Astros’ pitching staff has struggled this season, with an ERA of 4.86, ranking 28th in the league. This could be an area where the Angels can exploit and generate offense.

Houston’s pitchers have allowed a batting average against of .259, indicating that opposing teams have had success reaching base. This could be advantageous for the Angels’ hitters, who will look to capitalize on these opportunities.

Astros Betting Trends

  • SU Last 3 Games: 1-2 (33.3%)
  • Runline All Games: 84-74 (53.2%)
  • O/U All Games: 85-73 (53.8%)
  • SU as Favorite: 19-20 (48.7%)
  • Runline as Underdog: 71-48 (59.7%)
  • O/U as Underdog: 63-56 (52.9%)

Pitching Matchup

The Astros will rely on starter Jason Alexander, who has a 4.83 ERA and a WHIP of 1.39. He holds a win-loss record of 4-2, showing potential to be effective if he can limit base runners.

The Angels will counter with Kyle Hendricks, whose ERA is slightly better at 4.79. Hendricks’ experience and ability to manage games will be vital for the Angels’ success in this matchup.

Astros Gear Up for Crucial Game Against the Angels

Team Overview

The Houston Astros are set to play the Los Angeles Angels in a pivotal away game at Angel Stadium of Anaheim. The Astros currently find themselves in an intense battle for a postseason berth, making this matchup crucial. A win against the Angels is imperative to keep their playoff hopes alive.

With a record of 85-74, the Astros are pushing hard to maintain their standing. Their recent form has been inconsistent, winning only four of their last ten games. Houston’s ability to turn things around will be tested in this critical game.

Hitting Challenges

Houston’s hitting has seen mixed results, with a team batting average of .250, ranking 7th in the league. Despite their efforts, the team’s on-base percentage sits at 13th with .315, indicating potential room for improvement in getting players on base. Their slugging percentage of .396 ranks 16th, showcasing a need for more power in their lineup.

The Astros have hit 173 home runs this season, placing them 15th in the league. Meanwhile, their 243 doubles rank 17th, further underlining the need for offensive production. Their 465 walks, however, rank 25th, suggesting a struggle in plate discipline.

Pitching Insights

The Astros’ pitching staff holds an ERA of 3.89, ranked 13th, with a strong batting average against of .233, which is 5th in the league. Their pitchers have given up 196 home runs, ranking 20th, hinting at occasional vulnerability. However, with 70 quality starts, they rank 3rd, indicating a generally reliable rotation.

Houston’s pitching strength is further highlighted by their league-leading 1480 strikeouts. This ability to miss bats will be crucial against the Angels. The team has managed to convert most of their save opportunities, with only 16 blown saves ranking 1st in the league.

Key Players to Watch

Christian Walker is a key figure in the Astros lineup, leading the team with 24 home runs and 85 RBIs. His ability to change the game with one swing makes him a player to watch. Jose Altuve, with a batting average of .265 and 26 home runs, provides both leadership and offensive prowess.

Jeremy Peña has been consistent with a .304 average and 17 home runs, offering stability at the top of the order. Yainer Diaz’s 19 home runs and .253 average make him a valuable asset behind the plate. These players will need to deliver against the Angels to ensure a positive outcome.

Betting Trends

  • SU Last 3 Games: 1-2 (33.3%)
  • SU Last 5 Games: 1-4 (20.0%)
  • SU Last 10 Games: 4-6 (40.0%)
  • Runline as Underdog: 39-20 (66.1%)
  • O/U Last 10: 6-4 (60.0%)

Angels vs Astros Prediction: Astros -148

The Houston Astros are favored at -148 against the Los Angeles Angels in this game. The Astros have a significant edge in team performance, with an 85-74 record compared to the Angels’ 71-87. Houston’s road record of 39-39 is respectable and suggests they can perform well away from home.

The starting pitcher for Houston, Jason Alexander, although struggling in his last outing, has the potential to bounce back against the Angels’ lineup. Los Angeles has been underwhelming this season, evident from their last-place position in the AL West and a poor record in their last ten games (2-8).

Additionally, the Angels’ recent struggles and their subpar home record (38-39) indicate that they might find it difficult to counter the Astros. Houston’s lineup, bolstered by players with postseason experience, can capitalize on the Angels’ pitching, which ranks low in ERA.

Considering all these factors, the Astros appear to be in a stronger position to secure a victory. The projected final score is Astros 6 – Angels 3, reflecting Houston’s advantage in both pitching and hitting.

  • Angels vs Astros Prediction: Astros -148
  • Angels vs Astros Score: Astros 6 – Angels 3
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