NFL Game Prediction

Jaguars vs Chiefs Prediction & Betting Tips for NFL Week 5 on 10/6/2025

Want our best Jaguars vs Chiefs prediction for NFL week 5 on 10/6/25? Get our NFL betting tip as the Kansas City Chiefs travel to the Jacksonville Jaguars on 10/6/25 at EverBank Stadium, in Jacksonville. Knup Sports has your free pick!

The Kansas City Chiefs are set to take on the Jacksonville Jaguars in a Week 5 game of the 2025 NFL season. The game will be held at EverBank Stadium in Jacksonville, FL, on Monday, October 6, 2025, at 8:15 PM. Fans can catch the live broadcast on ABC.

Both teams have shown their strengths in the early stages of the season. The Chiefs, led by head coach Andy Reid, currently hold a 2-2 record, with a balanced performance at home and on the road. Meanwhile, the Jaguars, under the guidance of head coach Liam Coen, boast a strong 3-1 record and remain undefeated at home.

In terms of betting odds, the Chiefs are slightly favored with a -184 moneyline and a -3.5 point spread. The Jaguars, coming off a win against the 49ers, enter the game as underdogs with a +154 moneyline. The total over/under for the game is set at 46.5 points.

Jaguars vs Chiefs At a Glance

  • Game Date: Monday, October 6, 2025 at 8:15 PM
  • Stadium: EverBank Stadium in Jacksonville, FL USA — Outdoor Field
  • TV Channel: ABC
  • Kansas City Chiefs Record: 2-2-0
  • Jacksonville Jaguars Record: 3-1-0
  • Game Odds: Chiefs Moneyline -184, Jaguars Moneyline +154, Total Over/Under 46.5

Jacksonville Jaguars Ready for the Next Challenge

Offensive Performance Overview

The Jacksonville Jaguars have had an inconsistent start to their 2024 season on offense, ranking 24th in both scoring with 320 points and passing yards with 3,477 yards. Their rushing game hasn’t fared much better, sitting at 25th with 1,729 yards. This lack of offensive firepower has contributed to their challenges in converting first downs, where they are ranked 27th in the league.

Despite these struggles, the Jaguars have managed a relatively solid third-down conversion rate, ranking 19th with a 37.3% success rate. This indicates some resilience in crucial game situations, though there’s room for improvement. Trevor Lawrence continues to lead the charge with 845 passing yards and 5 touchdowns in four games.

Defensive Analysis

Defensively, the Jaguars have had their ups and downs, allowing 435 points and ranking 25th in opponent scoring. Their pass rush has been moderately effective with 34 sacks, putting them in the 15th spot league-wide. The defense has shown some ability to create turnovers, ranking 13th in opponent passing interceptions with 6 and 11th in fumbles recovered with 3.

However, the Jaguars have been vulnerable to giving up yardage, ranking 31st in opponent offensive yards allowed with 6,629. This points to potential issues in stopping drives and controlling the pace of the game. Despite these challenges, standout performances have come from players like Devin Lloyd and Foyesade Oluokun, contributing to their defensive efforts.

Recent Game Performances

The Jaguars have shown a mix of results in their recent games, highlighted by a notable 26-21 victory over the San Francisco 49ers. In that game, the rushing attack led by Travis Etienne Jr. with 151 yards proved crucial. The team also benefitted from a strong defensive showing with Devin Lloyd securing 2 interceptions.

In another win, this time 17-10 against the Houston Texans, the Jaguars leaned on a solid defensive performance and timely offense. The team showed resilience after a close 31-27 loss to the Cincinnati Bengals, where they amassed 261 passing yards. The early season performances showcase the team’s potential and the areas requiring improvement.

Key Players to Watch

Trevor Lawrence remains a pivotal figure for the Jaguars, demonstrating his passing ability with 845 yards and 5 touchdowns over four games. Running back Travis Etienne Jr. is another key player, ranking 3rd in the league with 394 rushing yards. His ability to break through defenses has been a highlight for the team.

On the defensive side, Devin Lloyd and Foyesade Oluokun have been instrumental. Lloyd’s recent game against the 49ers, where he had 2 interceptions, exemplifies his impact. Oluokun’s consistent tackling performance continues to anchor the defensive unit, providing stability against opposing offenses.

Team Betting Trends

  • O/U – After Win (REG): Last 5 REG Games (2024–2025) → 5-0 (100.0%)
  • SU – As Favorite (REG): Last 3 REG Games (2024–2025) → 3-0 (100.0%)
  • ATS – As Favorite (REG): Last 3 REG Games (2024–2025) → 3-0 (100.0%)
  • O/U – As Underdog (REG): Last 3 REG Games (2024–2025) → 3-0 (100.0%)
  • SU – Home Games (REG): Last 3 REG Games (2024–2025) → 3-0 (100.0%)
  • ATS – Home Games (REG): Last 3 REG Games (2024–2025) → 3-0 (100.0%)
  • O/U – Away Games (REG): Last 3 REG Games (2024–2025) → 3-0 (100.0%)

The Chiefs Seek Victory Against the Jaguars: A Deep Dive into Kansas City’s Upcoming Game

Jaguars Offensive Overview

The Jacksonville Jaguars have demonstrated a diverse offensive strategy this season. With a focus on both the ground and air game, they’ve kept opposing defenses on their toes. Their balanced approach might challenge the Chiefs’ defense, which is currently ranked 4th in opponent score.

The Jaguars’ quarterback has been pivotal in leading the charge, showcasing a strong arm and decision-making skills. Complementing this is their running game, which has steadily gained traction as the season progresses. Their ability to mix up play calls can be a significant factor in this game.

Jaguars Defensive Strengths

Defensively, the Jaguars have made strides in their ability to pressure the quarterback. Their defensive line has been effective in generating sacks and creating disruption in the backfield. The Chiefs’ offensive line will need to be on alert to protect Patrick Mahomes.

Furthermore, the Jaguars’ secondary has been opportunistic, seizing interception opportunities when presented. This could be crucial against Mahomes, who has been efficient this season but could face challenges from a well-prepared secondary.

Key Jaguars Players to Watch

The Jaguars’ standout players on offense include their leading receiver, who has been a reliable target all season. His ability to stretch the field will test the Chiefs’ secondary. In the backfield, their running back has shown the capability to break big plays, adding another dimension to their attack.

Defensively, a key player to watch is their edge rusher, who has consistently applied pressure on opposing quarterbacks. His presence will be a factor that the Chiefs’ offensive line must account for to maintain offensive fluidity.

Jaguars Recent Form

In recent games, the Jaguars have shown both resilience and adaptability. Their ability to come from behind in tough situations highlights their tenacity. Facing the Chiefs, they will need to harness this spirit to challenge a top contender.

Their recent victories have bolstered their confidence, and they enter this game looking to prove themselves against a formidable opponent. This game presents an opportunity for the Jaguars to make a statement in the league.

Jaguars Betting Trends

  • SU – Last 5 Games: 3-2 (60%)
  • ATS – Last 5 Games: 3-2 (60%)
  • O/U – Last 5 Games: 2-3 (40%)
  • SU – Home Games: 4-1 (80%)
  • ATS – Home Games: 4-1 (80%)

Jaguars vs Chiefs Prediction: Over 46.5

The Kansas City Chiefs and Jacksonville Jaguars are set to face each other with a total points line of 46.5. The Chiefs have an explosive offensive unit led by Head Coach Andy Reid and Offensive Coordinator Matt Nagy. Historically, the Chiefs have been able to score well on the road, which could contribute to a high-scoring game.

The Jacksonville Jaguars have shown strong offensive performances in recent games, especially at home. Their recent trend of going over the total when playing as underdogs and after a win adds confidence to an over pick. The Jaguars have covered the total in their last three games as underdogs this season.

Additionally, both teams have had high-scoring games in their head-to-head history, although most were under the total in the past seasons. However, considering their current forms and offensive capabilities, the potential for this game to go over is substantial.

With both teams capable of producing high offensive output, the game could easily surpass the set total. A projected final score of 28-24 in favor of the Chiefs supports taking the over on the total points line.

  • Jaguars vs Chiefs Prediction: Over 46.5
  • Jaguars vs Chiefs Score: Chiefs 28 – Jaguars 24
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