CFB Game Prediction

Indiana vs Michigan State Prediction & Betting Tips for CFB Week 8 on 10/18/2025

Want our best Indiana vs Michigan State prediction for 10/18/25? Get our College Football betting tip as the Michigan State travel to Indiana in Week 8 on 10/18/25 at Memorial Stadium (Bloomington, IN), in Indiana. Knup Sports has your free CFB pick!

In Week 8 of the 2025 college football season, the Michigan State Spartans travel to Bloomington, Indiana, to take on the Indiana Hoosiers at Memorial Stadium. The game is set to kick off at 3:30 PM on Saturday, October 18, and will be broadcast on PEAC. The Spartans, part of the Big Ten Conference, come into this matchup with a record of 3-3.

The Indiana Hoosiers, also in the Big Ten, are having an impressive season with a perfect 6-0 record and currently hold the #3 spot in both the AP and Coaches Polls. Their home record stands at 4-0, showcasing their strength on familiar turf. The Spartans have struggled on the road, holding a 0-2 road record, and are yet to secure a conference win this season.

Given the current betting odds, Indiana is heavily favored with a moneyline of -4520, while the Spartans stand at +1598. The spread leans towards Indiana with -26.5, and the total over/under is set at 52.5 points. This matchup offers a significant challenge for Michigan State against a well-ranked Indiana team that has been dominant throughout the season.

Indiana vs Michigan State At a Glance

  • Game Date: Saturday, October 18, 2025, at 3:30 PM
  • Venue: Memorial Stadium in Bloomington, IN
  • TV Channel: PEAC
  • Michigan State Record: 3-3 overall, 0-2 on the road
  • Indiana Record: 6-0 overall, 4-0 at home
  • Game Odds: Indiana Hoosiers favored with a spread of -26.5

Hoosier Hopes: Indiana’s Away Game Challenge

Offensive Overview

Indiana Hoosiers have put together a strong offensive performance this season, ranking 4th in points for with 269. Their rushing attack is particularly noteworthy, with 1,519 yards and a 7th place rank. The passing game, while not as dominant, has accumulated 1,567 yards, placing them 40th in the rankings.

In their recent games, the Hoosiers have demonstrated offensive versatility. Against Illinois, they racked up a whopping 312 rushing yards and 267 passing yards. Their ability to shift between run and pass makes them a multifaceted threat.

Defensive Dynamics

The Hoosiers’ defense has also been impressive, allowing just 68 points, placing them 29th in points against. Their defensive line is a standout with 22 sacks, ranking 4th overall. In terms of turnovers, they’ve secured 10 interceptions, putting them at the 11th spot.

In their game against Oregon, Indiana’s defense limited the Ducks to just 81 rushing yards and 186 passing yards. Their knack for creating turnovers was on display with two key interceptions, stifling Oregon’s offensive efforts.

Key Players

Fernando Mendoza leads the team as a top quarterback with 1,423 passing yards and 17 touchdowns. His leadership has been pivotal in orchestrating Indiana’s offensive schemes. On the ground, Roman Hemby stands out with 421 rushing yards and two touchdowns.

Wide receivers Omar Cooper Jr. and Elijah Sarratt have been crucial in the passing game, with 490 and 509 receiving yards, respectively. Their ability to find openings in defenses has been a significant asset for the Hoosiers.

Recent Game Performance

Indiana’s recent performance against Oregon saw them secure a 30-20 victory, showcasing both their offensive and defensive strengths. They controlled the game with 215 passing yards and 128 rushing yards. Their ability to limit Oregon’s ground game played a critical role in their success.

In their game against Iowa, the Hoosiers managed a close 20-15 win. They demonstrated resilience by edging out the Hawkeyes in first downs and total offensive yards, showing their ability to grind out tough victories.

Betting Trends

  • SU – As Favorite: 26-2 (92.9%) in the last 28 games
  • SU – Home Games: 12-0 (100.0%) in the last 12 games
  • ATS – Totals ≥ 50: 4-0 (100.0%) in the last 4 games
  • O/U – Home Games: 3-0 (100.0%) in the last 3 games
  • O/U – Away Games: 9-2 (81.8%) in the last 11 games

Michigan State Spartans Look to Rebound in Away Game Against the Hoosiers

Offensive Challenges

The Michigan State Spartans’ offensive stats reveal a struggle in the 2025 season, with their total points for ranking at 46th nationally. Their passing game, generating 1203 yards, sits at 90th place, while their rushing yards tally of 794 ranks 92nd. This offensive output places them in a challenging position as they prepare for their next game.

Quarterback Aidan Chiles has led the Spartans in passing with 1019 yards, ranking 94th nationally. Despite his efforts, the team has struggled with consistency, as evidenced by their recent performances. The Spartans will need to find a way to elevate their offensive game to contend against the Hoosiers.

Defensive Struggles

Defensively, Michigan State has faced significant challenges, allowing 191 points, which ranks 114th in the nation. However, their ability to pressure the quarterback has been a bright spot, with 13 sacks placing them 13th nationally. The Spartans’ defense will need to step up and create more turnovers to stop the Hoosiers’ offense.

Their interception count of three ranks them 4th nationally, showing that they have potential to disrupt the passing game. Despite their struggles, the defense has shown moments of excellence and will need to capitalize on these to prevent further points against them.

Key Players

Running back Makhi Frazier has been a crucial part of the Spartans’ offense with 383 rushing yards, ranking 84th nationally. His performance will be vital in opening up the passing game for Chiles and keeping the offense balanced. Wide receiver Nick Marsh leads the team with 29 receptions and 340 receiving yards, which ranks him 59th and 115th nationally, respectively.

Tight end Jack Velling has also been a reliable target, with 13 receptions and 127 receiving yards. His presence in the middle of the field provides a safety net for Chiles, especially in critical third-down situations.

Recent Game Performances

Michigan State’s recent games have been tough, with the Spartans coming off a 13–38 loss against UCLA. In their previous away game against Nebraska, they managed 17 first downs and 156 passing yards but fell short with a 38-27 loss. These results highlight the need for improved execution in their upcoming away game against Indiana.

Despite these setbacks, the Spartans secured a 41-24 victory against Youngstown State earlier in the season, showcasing their potential when the offense and defense click together. Replicating this form will be crucial to their success against the Hoosiers.

Team Betting Trends

  • O/U – As Underdog: 6-0 in last 6 games
  • SU – As Favorite: 17-4 in last 21 games
  • O/U – After Win: 5-0 in last 5 games
  • O/U – Away Games: 4-0 in last 4 games
  • O/U – All Games: 9-3 in last 12 games

Indiana vs Michigan State Prediction: Over 52.5

Indiana’s potent offense is currently ranked 4th in points scored, with a total of 269 points this season. Their ability to score consistently, combined with Michigan State’s defensive struggles, ranks them 114th in points allowed, indicates a high-scoring potential for this game.

Michigan State’s offense, although not as explosive, has managed to put up 177 points this season. In a game against a top-tier team like Indiana, they are likely to contribute to a high total score, even if a significant portion comes from Indiana’s side.

Indiana’s recent games have shown a trend of surpassing the set totals, particularly in home games where they are 3-0 in hitting the over. Given Indiana’s home performance and Michigan State’s defensive vulnerabilities, this game is likely to exceed the 52.5 total.

With Indiana’s offensive firepower and Michigan State’s capability to at least add some points, the prediction leans towards a game total exceeding 52.5. The likely scenario is a dominant Indiana performance with Michigan State managing some scoring drives.

  • Indiana vs Michigan State Prediction: Over 52.5
  • Indiana vs Michigan State Score: Indiana 42 – Michigan State 17
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