In this week 11 NFL regular season preview between Seahawks and 49ers, see who like to win the game and cover the spread.
FOX will broadcast the week 11 NFC West matchup between the 49ers and Seahawks from Levi's Stadium in Santa Clara, CA. The 49ers are heavily favored with a money line of -293, while the Seahawks' money line odds are +239. The 49ers are -6.5 point favorites, and the over/under line is set at 49.5 points for this 4:05 ET start on Sunday, November 17th.
Seahawks vs. 49ers Matchup At A Glance
- Sport: NFL
- Teams: Seattle Seahawks at San Francisco 49ers
- Where: Santa Clara at Levi's Stadium
- Date: Sunday, November 17th
- Betting Odds SF -6.5, SEA +239 | SF -293 O/U 49.5

Seahawks Preview:
Seattle heads into week 11 against the 49ers looking to snap a two-game losing streak, which includes a 31-10 loss to the Bills in week 8 and a 26-20 loss to the Rams in week 9. The Seahawks are 4-5 this season and sit 4th in the NFC West. They are 0-2 in division games and 1-4 in conference play. Our power rankings have Seattle 22nd, and they have a 6.3% chance of making the playoffs and a 3.7% chance of winning the division.
Seattle has an average scoring margin of -1.2 points per game and is 2-6-1 against the spread. They are 1-4 ATS as underdogs and 1-2-1 as favorites. Their O/U record is 5-4, with the under hitting in three straight games.
Seahawks Offense Breakdown
Heading into week 11, the Seahawks rank 20th in our offensive power rankings. They lead the NFL in passing yards per game (268.2) and rank 2nd in passing attempts per game (38.1). Geno Smith threw for 363 yards and 3 touchdowns in week 9, but he also had 3 interceptions and was sacked 7 times. Seattle ranks 23rd in the NFL in 3rd-down conversion rate (35.2%).
On the ground, the Seahawks are 25th in rushing attempts and 27th in rushing yards per game, averaging 91.2 yards. Kenneth Walker III had 83 yards on 25 carries in week 9. Seattle is 4th in the NFL in red zone conversion rate, scoring on 60.9% of their trips inside the 20.
Seahawks Team Defense
In their 26-20 overtime loss to the Rams, the Seahawks' defense gave up 298 passing yards and allowed two passing touchdowns. They held the Rams to just a 23.1% conversion rate on third down and to 68 rushing yards on 24 attempts. Despite this, the Seahawks didn't manage to record any sacks and lost the QB hit and tackles for loss differentials.
The Seahawks' defense did force one interception and limited the Rams to 56.8% completions. However, the Rams still finished with 366 total yards, including 298 through the air.49ers Preview:
With two straight wins, the 49ers are now 5-4 and sit 6th in our NFL power rankings. After a week 8 victory over the Cowboys, San Francisco followed it up with a 23-20 win over the Buccaneers in week 10. The 49ers were favored by 6.5 points but couldn’t cover the spread, bringing their ATS record to 4-5. They’ve been the favorite in all of their games so far, with an average scoring margin of +3.4 points per game.
Heading into week 11, the 49ers have a 49.6% chance of making the playoffs and a 35.7% chance of winning the NFC West. They are 2nd in the division with a 1-2 record, including a win over the Seahawks in week 6. San Francisco is 3-2 at home and 2-2 on the road this season.
49ers Offense Breakdown
Heading into week 11, the 49ers are 6th in our offensive power rankings, averaging 25.9 points per game. They rank 2nd in passing yards per game with 262.8, despite being 19th in passing attempts. On the ground, they average 149.7 rushing yards per game, ranking 5th, on 30 attempts per game. San Francisco is 7th in the NFL in 3rd-down conversions, with a rate of 43.5%.
In week 10, Brock Purdy threw for 353 yards and 2 touchdowns, completing 25 of 36 passes against the Buccaneers. Jauan Jennings led the team with 7 catches for 93 yards, while Christian McCaffrey had 39 rushing yards on 13 carries. The 49ers scored 10 points in the 4th quarter, converting 5 of 11 3rd downs.
49ers Team Defense
In their 23-20 win over the Buccaneers, the 49ers' defense allowed just 105 passing yards and held Tampa Bay to 215 total yards. They defended the run well, allowing only 110 yards on 27 attempts. Despite giving up one passing touchdown, San Francisco limited the Bucs to a 3.6 yards per attempt.
The 49ers' defense also recorded two sacks and held Tampa Bay to a 35.7% conversion rate on third downs. Although they didn't generate much in the way of quarterback hits, their two sacks helped to disrupt the Buccaneers' passing game.Seahawks vs 49ers Betting Odds, Trends & Analysis
- Through their last three road contests, the Seahawks offense has averaged 28 points per game while allowing an average of 25. Seattle posted an overall record of 2-1 while going 1-1-1 ATS.
- When looking at their past three home matchups, San Francisco has an ATS record of 1-2 while averaging 27 per game. The team went 2-1 overall in these games.
- Going back to their previous ten games as the underdog, Seattle has an ATS mark of 5-5 while going 2-8 straight up.
- The last ten games that San Francisco was favored, they have an ATS mark of 4-6 while going 5-5 straight up.
Seahawks vs 49ers Free Pick
- KnupSports.com Free Betting Pick: Seahawks +6.5 Be sure to check out our other NFL Football betting previews for this week. KnupSports.com also updates their sports betting picks page daily with plays across all sports.