Arizona Cardinals vs Buffalo Bills Matchup

Read on to get betting odds and analysis in our week 1 Cardinals vs Bills pick and preview and see who we think will win and cover in Orchard Park.

The over/under line is set at 48 points as the Bills are favored on the money line at -271 in their week one matchup against the Cardinals. Buffalo is favored by -6 on the point spread. This non-conference matchup is the first game of the season for both teams and is being televised on CBS at 1:00 ET.

Cardinals vs. Bills Matchup At A Glance

  • Sport: NFL
  • Teams: Arizona Cardinals at Buffalo Bills
  • Where: Orchard Park at Highmark Stadium
  • Date: Sunday, September 8th
  • Betting Odds BUF -6, ARI +220 | BUF -271 O/U 48

Cardinals Preview:

The Cardinals' 2023 season was a tough one, as they won just four games, going 4-13 overall. Within their own division, they struggled even more, going 0-6 and finishing at the bottom of the NFC West. Arizona's only wins within their division came against the Seahawks and Rams, both of which they beat once. When playing outside of their division, the Cardinals went 3-9.

As underdogs in every game, the Cardinals were 9-8 against the spread. They were 5-3 ATS at home and 4-5 ATS on the road. Their over/under record was 10-7, with an average of 46.2 points per game.

Cardinals Offense Breakdown

The Cardinals' passing game struggled last season, finishing 26th in passing yards with just 184.9 per game. They were also 24th in scoring, averaging 19.4 points per game, and 24th in the league in their overall power ranking. Arizona was more successful in the running game, averaging 139.1 rushing yards per game, the 3rd best in the league, and 5 yards per attempt, ranking 2nd in the NFL.

Overall, the Cardinals averaged 324.1 yards per game, ranking 19th in the league. They also struggled in the passing game, finishing 23rd in passing attempts. Their inability to move the ball through the air limited their overall offensive success, as they ranked 26th in road games, scoring just 15.8 points per game.

Cardinals Team Defense

Arizona's defense really struggled last season, finishing 32nd in the defensive power rankings. They allowed 26.8 points per game, which was 31st in the NFL. The Cardinals particularly struggled at home, giving up 29.8 points per game. Their inability to pressure the quarterback was a big issue, as they were below average in both sacks and quarterback hits.

Opposing offenses consistently attacked the Cardinals through the air, as they had the 3rd fewest passing attempts against them. Despite this, Arizona gave up the 2nd highest completion percentage in the league, at 68.6%, and allowed quarterbacks to collectively post a passer rating of 101, ranking 31st in the league.

Bills Preview:

The Cardinals' 2023 season was a tough one, as they won just four games, going 4-13 overall. Within their own division, they struggled even more, going 0-6 and finishing at the bottom of the NFC West. Arizona's only wins within their division came against the Seahawks and Rams, both of which they beat once. When playing outside of their division, the Cardinals went 3-9.

As underdogs in every game, the Cardinals were 9-8 against the spread. They were 5-3 ATS at home and 4-5 ATS on the road. Their over/under record was 10-7, with an average of 46.2 points per game.

Bills Offense Breakdown

Buffalo's playoff run ended in the AFC Divisional round with a 27-24 loss to the Chiefs, but they still finished the season with an 11-6 record. The Bills were tough as home favorites, going 7-2 straight-up, but they were only 4-5 vs. the spread. When favored overall, the Bills were 11-5, and they were 1-2 as the underdog. Against the spread last season, the Bills were 8-11.

Buffalo's games averaged 45.3 points last season, which was 11th in the league. Their over/under record for the season was 8-11. On the road, the Bills went 3-5 vs. the spread, and at home, they went 5-6 vs. the spread. Against teams with losing records, the Bills went 3-6 vs. the spread, and against teams with winning records, they went 5-5 vs. the spread.

Bills Team Defense

Buffalo's defense was one of the best in the league last season, finishing 3rd in points allowed at just 18.7 per game. They excelled in getting to the quarterback, ranking 4th in both sacks and quarterback hits. The Bills also forced 30 takeaways, the 2nd best figure in the league, and had the 2nd best turnover differential.

Overall, the Bills were the 9th best defense in the NFL last season, holding opponents to 310.9 yards per game. They were tough against the pass, giving up only 198.7 yards per game through the air and allowing the 2nd fewest passing touchdowns. Against the run, Buffalo gave up 4.6 yards per attempt, ranking 11th in the league.

Cardinals vs Bills Betting Odds, Trends & Analysis

  • Arizona has played well in their previous three road games, going 2-1 straight up. In this stretch, they averaged 25 points per game while allowing 22. The team also performed well vs the spread at 2-1.
  • In their last five games at home, the Bills have a straight up record of 3-2 while going 2-3 vs the spread. The team's offense averaged 23 points per game in these contests.
  • The last ten games that Arizona was the underdog, they have an ATS mark of 6-4 while going 3-7 straight up.
  • Over the team's last five games as the favorite, the Bills struggled vs the spread going just 2-3. However, they still had a straight up mark of 4-1.

Cardinals vs Bills Free Pick

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