Missouri is the heavy favorite in this week four matchup against Vanderbilt, with the point spread set at -21 in favor of the Tigers. The game is scheduled for 4:15 ET on Saturday, September 21st, at Faurot Field at Memorial Stadium in Columbia, and SEC Network will handle the broadcast. Vanderbilt enters the game with a 2-1 record, while Missouri is undefeated at 3-0. The over/under line is currently at 53.5 points.
Commodores vs. Tigers Matchup At A Glance
- Sport: CFB
- Teams: Vanderbilt Commodores at Missouri Tigers
- Where: Columbia at Faurot Field at Memorial Stadium
- Date: Saturday, September 21st
- Betting Odds MISSR -21, VAND +900 | MISSR -1742 O/U 53.5

Commodores Preview:
Vanderbilt is looking to bounce back after a road loss to Georgia State, bringing their record to 2-1 for the season. The Commodores were favored by -8.5 points but ended up losing 36-32, resulting in both a straight-up and ATS loss. The game’s total score of 68 points surpassed the over/under line of 44.5 points.
After trailing 3-0 in the first quarter, Vanderbilt managed to take a 10-9 lead at halftime. However, Georgia State outscored them 10-0 in the third quarter, and despite an 8-point rally in the fourth, the Commodores fell short of a comeback.
Commodores Offense Breakdown
Vanderbilt's offense put up 381 yards in their 36-32 loss to Georgia State, with 270 yards coming through the air. Diego Pavia completed 54.5% of his passes for 270 yards, throwing two touchdowns and finishing with a passer rating of 101.83. Eli Stowers was his top target, hauling in nine receptions for 110 yards.
The Commodores' offense moved the chains 23 times, but their ground game was limited to 111 yards. Sedrick Alexander led the rushing attack with 42 yards on 11 carries and added a rushing touchdown.
Commodores Team Defense
Vanderbilt's defense will be looking to improve after giving up 426 total yards and 36 points in their last game. Georgia State's offense found success through the air, throwing for 269 yards and three touchdowns. The Commodores' secondary did manage to pick off one pass, but they allowed a completion rate of 63.4% on 41 attempts. On the ground, Vanderbilt surrendered 157 yards and a touchdown.
Tigers Preview:
Vanderbilt is looking to bounce back after a road loss to Georgia State, bringing their record to 2-1 for the season. The Commodores were favored by -8.5 points but ended up losing 36-32, resulting in both a straight-up and ATS loss. The game’s total score of 68 points surpassed the over/under line of 44.5 points.
After trailing 3-0 in the first quarter, Vanderbilt managed to take a 10-9 lead at halftime. However, Georgia State outscored them 10-0 in the third quarter, and despite an 8-point rally in the fourth, the Commodores fell short of a comeback.
Tigers Offense Breakdown
Missouri's offense, led by quarterback Brady Cook, put up 448 total yards in their 27-21 win over Boston College. Cook completed 70% of his passes for 264 yards and one touchdown, earning a passer rating of 108.19. Luther Burden III was his top target, hauling in six receptions for 117 yards.
The Tigers' ground game was effective, with Nate Noel rushing for 121 yards on 22 carries. Missouri finished with 184 rushing yards and found the end zone once on the ground.
Tigers Team Defense
Missouri's defense allowed just 49 rushing yards in their most recent game, holding Boston College to 298 total yards. Despite giving up three passing touchdowns, the Tigers' defense came up with two key interceptions. Boston College completed 16 of 28 pass attempts for 249 yards through the air.
Commodores vs Tigers Betting Odds, Trends & Analysis
- In their last three games away from home, the Vanderbilt Commodores have a straight up record of 0-3 while going 1-2 vs the spread. The team's offense averaged 20 points per game in these contests.
- In their last three home games, Missouri has averaged 27 points per game while allowing 15. The team's record in this stretch was 2-1 while going 3-0 vs. the spread.
- Looking back on the team's last three games as the underdog, the Vanderbilt Commodores have a straight up record of 1-2. Their record vs the spread in these games was 2-1.
- Missouri has done well both straight up and vs the spread when favored to win the game, going 3-0 SU and 3-0 ATS in their last three games.
Vanderbilt Commodores vs Missouri Tigers Free Pick
- KnupSports.com Free Betting Pick: Missouri Tigers -21 Be sure to check out our other CFB Football betting previews for this week. KnupSports.com also updates their sports betting picks page daily with plays across all sports.