Check out our free Louisville Cardinals vs Virginia Cavaliers pick and preview for this CFB week 7 game in Charlottesville. See who we like to win and cover the spread in this week 7 CFB matchup.
Coming into this week seven matchup, the Louisville Cardinals are on the road vs. the Virginia Cavaliers. The game is set for 3:30 ET at Scott Stadium in Charlottesville and will be broadcast on ACCN. The Cardinals are favored by -7.5 points, and the over/under line is at 54.5 points. Louisville has a 3-2 record, while Virginia sits at 4-1 this season.
Cardinals vs. Cavaliers Matchup At A Glance
- Sport: CFB
- Teams: Louisville Cardinals at Virginia Cavaliers
- Where: Charlottesville at Scott Stadium
- Date: Saturday, October 12th
- Betting Odds LOU -7.5, LOU -287 | VIR +231 O/U 54.5

Cardinals Preview:
Louisville enters Week 7 against Virginia with a 3-2 record, ranked 16th in our power rankings. They have a 91.9% chance of becoming bowl-eligible but only a 4.9% shot at winning the Atlantic Coast. The Cardinals are 2-1 at home and 0-1 on the road this season.
Louisville’s ATS record stands at 2-2, and they’ve been favored in three of their five games, going 2-1 against the spread as favorites. Their average scoring margin is +19 points per game.
Their over/under record is 3-1, with an average line of 53.4 points. This week’s line is 54.5 points, and their games have averaged 58.2 points per contest.
Cardinals Offense Breakdown
Louisville’s offense is ranked 18th in our CFB offensive power rankings heading into week 7. They are also 18th in points per game, scoring 38.6. Tyler Shough has thrown for 1,443 yards and has a passer rating of 118. He has 13 touchdowns and just two interceptions. Louisville is 22nd in passing yards per game, averaging 303.4, and they are 29th in completions per game.
Shough’s completion percentage is 64.5%. Overall, Louisville ranks 25th in completion percentage, completing 66.5% of their passes. Ja’Corey Brooks leads the team with 489 receiving yards and six touchdowns. Louisville is averaging 179.2 rushing yards per game.
Cardinals Team Defense
Louisville's defense, ranked 26th nationally, has allowed an average of 19.6 points per game this season. In their recent game against SMU, they gave up 34 points, including 291 passing yards and 194 rushing yards.
Opponents have averaged 115.2 rushing yards per game against Louisville, while quarterbacks have posted a 92.2 passer rating, completing 67.4% of their throws.
Cavaliers Preview:
Louisville enters Week 7 against Virginia with a 3-2 record, ranked 16th in our power rankings. They have a 91.9% chance of becoming bowl-eligible but only a 4.9% shot at winning the Atlantic Coast. The Cardinals are 2-1 at home and 0-1 on the road this season.
Louisville’s ATS record stands at 2-2, and they’ve been favored in three of their five games, going 2-1 against the spread as favorites. Their average scoring margin is +19 points per game.
Their over/under record is 3-1, with an average line of 53.4 points. This week’s line is 54.5 points, and their games have averaged 58.2 points per contest.
Cavaliers Offense Breakdown
Virginia’s offense ranks 69th in our college football offensive power rankings heading into week 7. They are averaging 29 points per game, placing them 49th nationally. Quarterback Anthony Colandrea has thrown for 1,211 yards with a 66.4% completion rate, leading the Cavaliers’ passing attack. Virginia ranks 44th in passing attempts and 35th in completions per game.
Colandrea has eight touchdown passes and four interceptions, with a passer rating of 98. Virginia is averaging 252 passing yards per game. On the ground, they are 57th nationally with 181 rushing yards per game. Xavier Brown leads the team with 315 rushing yards, averaging 8 yards per carry. Malachi Fields has 412 receiving yards and three touchdowns.
Cavaliers Team Defense
Virginia's defense played a key role in their recent 24-14 win over Boston College, allowing just 14 points. They held Boston College to 65 rushing yards on 29 attempts, while giving up 254 passing yards and forcing two interceptions.
On the season, Virginia's defense ranks 33rd nationally, allowing 21.6 points per game. They are 36th in the country against the run, giving up just 113.2 rushing yards per game, but they have struggled against the pass, ranking 143rd by allowing 266.4 passing yards per game.
Cardinals vs Cavaliers Betting Odds, Trends & Analysis
- When looking at their past ten road matchups, Louisville has an ATS record of 2-8 while averaging 23 per game. The team went 4-6 overall in these games.
- The Virginia Cavaliers are 4-0-1 ATS in their last home games and 3-2 straight-up.
- In their last three games as the betting underdog, the Virginia Cavaliers have a straight up record of 1-2 and an ATS mark of 2-1.
- Through their last three games as the favorite, the Louisville Cardinals have an ATS record of 2-1 and a straight up mark of 2-1.
Louisville Cardinals vs Virginia Cavaliers Free Pick
- KnupSports.com Free Betting Pick: Virginia Cavaliers +7.5 Be sure to check out our other CFB Football betting previews for this week. KnupSports.com also updates their sports betting picks page daily with plays across all sports.