Louisville Cardinals vs Pittsburgh Panthers Matchup

Check out our free Pittsburgh Panthers vs Louisville Cardinals pick and preview for this CFB week 13 game in Louisville. See who we like to win and cover the spread in this week 13 CFB matchup.

Coming into this week 13 matchup, the Louisville Cardinals are favored at -8 as they host the Pittsburgh Panthers at L&N Federal Credit Union Stadium in Louisville. Kick-off is set for 4:00 ET, and ESPN2 will be covering the game. The over/under line is currently at 57.5 points. The Panthers have a 7-3 record this season, while the Cardinals are 6-4 overall.

Panthers vs. Cardinals Matchup At A Glance

Sport: CFB
Teams: Pittsburgh Panthers at Louisville Cardinals
Where: Louisville at L&N Federal Credit Union Stadium
Date: Saturday, November 23rd
Betting Odds LOU -8, PITT +252 | LOU -316 O/U 57.5

Panthers Preview:

With a 7-3 record, Pittsburgh is 100% certain to be bowl-eligible, but they have no chance of winning the Atlantic Coast. They are ranked 41st in our power rankings heading into their Week 13 matchup against Louisville.

Pittsburgh has been favored in five of their ten games this season, going 4-1 as the favorite. Their average scoring margin is +10 points per game, and they have a 6-3 record against the spread.

The over/under line for this week is 57.5 points. Pittsburgh’s games have averaged 60 points, with an average over/under line of 58.6 points. Their over/under record is 3-6 this season.

Panthers Offense Breakdown

Heading into week 13, Pittsburgh's offense is averaging 35 points per game, ranking 20th in college football. However, they sit 56th in our offensive power rankings. Their passing game is a key strength, with 38.7 attempts per game, ranking 11th nationally, and they are 18th in passing yards, averaging 284.4 per game.

Eli Holstein leads the Panthers with 2,177 passing yards and 17 touchdowns, posting a passer rating of 96. Pittsburgh is 81st in rushing, averaging 145 yards per game. Desmond Reid has 738 rushing yards this season.

Panthers Team Defense

Heading into their matchup with Louisville, Pittsburgh's defense is ranked 18th nationally against the run, allowing just 107.1 rushing yards per game. In their recent game against Clemson, they gave up only 58 rushing yards on 27 attempts. However, the secondary allowed 288 passing yards and two touchdowns, contributing to the 24 points they surrendered in the 24-20 loss.

Opposing quarterbacks have averaged a passer rating of 84.5 and a 60.1% completion rate against Pittsburgh, throwing for 255.3 yards per game, which ranks 140th nationally. On average, Pittsburgh's defense faces 36.9 pass attempts per game, the 97th most in the country.

Cardinals Preview:

Pittsburgh has been favored in five of their ten games this season, going 4-1 as the favorite. Their average scoring margin is +10 points per game, and they have a 6-3 record against the spread.

The over/under line for this week is 57.5 points. Pittsburgh’s games have averaged 60 points, with an average over/under line of 58.6 points. Their over/under record is 3-6 this season.

Cardinals Offense Breakdown

Louisville’s offense has been impressive this season, averaging 36.1 points per game, ranking 14th nationally. They are 12th in our offensive power rankings heading into week 13. Tyler Shough has thrown for 2,774 yards with a passer rating of 101, leading the offense with 21 touchdowns and six interceptions.

Louisville ranks 17th in passing yards per game, averaging 284.8, and they are 23rd in both passing attempts and completions. On third downs, they convert 37.9% of their chances. Isaac Brown leads the ground game with 803 rushing yards, averaging 7 yards per carry. Ja’Corey Brooks has 945 receiving yards and eight touchdowns.

Cardinals Team Defense

Louisville's defense has allowed an average of 25.6 points per game this season, including 38 points in their recent 38-35 loss to Stanford. Despite giving up 406 total yards, they held Stanford to just 83 rushing yards on 37 attempts but allowed 323 passing yards and four touchdowns through the air.

Opponents are averaging 233.3 passing yards per game against Louisville, completing 63.4% of their throws. The defense has faced the 80th most passing attempts in the country and ranks 131st in passer rating allowed. On the ground, they are giving up 140.5 rushing yards per game.

Panthers vs Cardinals Betting Odds, Trends & Analysis

In their last ten games away from home, the Pittsburgh Panthers have a straight up record of 3-7 while going 3-7 vs the spread. The team's offense averaged 20 points per game in these contests.
In their last three games at home, the Louisville Cardinals have a straight up record of 2-1 while going 1-2 vs the spread. The team averaged 33 points per game in this stretch.
Through their last three games as the betting underdog, the Pittsburgh Panthers have a strong record vs the spread going 2-1. Their straight up mark in these contests is 1-2.
In their last three contests as the favorite, Louisville has a poor record vs the spread going 0-3. But, they still put together a straight up mark of 2-1.