NFL Game Prediction

Eagles vs Rams Prediction & Betting Tips for NFL Week 3 on 9/21/2025

Want our best Eagles vs Rams prediction for NFL week 3 on 9/21/25? Get our NFL betting tip as the Los Angeles Rams travel to the Philadelphia Eagles on 9/21/25 at Lincoln Financial Field, in Philadelphia. Knup Sports has your free pick!

As the Los Angeles Rams take on the Philadelphia Eagles in Week 3 of the 2025 NFL season, both teams enter the game with unblemished 2-0 records. The Rams, under the guidance of head coach Sean McVay, have shown early dominance with victories over the Tennessee Titans and the Houston Texans. Meanwhile, the Eagles, led by head coach Nick Sirianni, have secured wins against the Kansas City Chiefs and Dallas Cowboys, showcasing their ability to compete against top-tier opponents.

The game will be held at Lincoln Financial Field in Philadelphia, PA, where the Eagles boast a strong home record. Weather conditions are expected to be mild with a light breeze and broken clouds, setting the stage for an exciting afternoon of football. Viewers can catch the action on FOX at 1:00 PM on Sunday, September 21, 2025.

In terms of betting odds, the Eagles are slight favorites with a moneyline of -185 and a spread of -3.5, while the Rams have a moneyline of +156 and a spread of +3.5. The over/under is set at 44.5 points, indicating a closely contested game is anticipated. With both teams undefeated, this matchup promises an intriguing battle as they vie for early control in their respective divisions.

Eagles vs Rams At a Glance

  • Stadium Location: Lincoln Financial Field in Philadelphia, PA USA — Outdoor Field
  • Game Time: Sunday, September 21, 2025 at 1:00 PM (Afternoon Game)
  • TV Channel: FOX
  • Weather Forecast: Mild day with a light breeze, and conditions described as ‘Broken Clouds’
  • Team Records: Both Los Angeles Rams and Philadelphia Eagles have a season record of 2-0-0
  • Game Odds: Eagles favored with a moneyline of -185; Rams at +156

Philadelphia Eagles Prepare for a Key Home Game

Offensive Performance

The Philadelphia Eagles have displayed a potent offensive lineup this season. Ranking 7th in scoring with 463 points, they have been effective in putting up points on the board. Their rushing game is particularly strong, sitting at 2nd in the league with 3048 rushing yards.

However, the passing game has been less impressive, as they rank 29th with 3194 passing yards. This discrepancy between the rushing and passing game indicates a potential area for improvement in their offensive strategy.

Defensive Strengths

The Eagles’ defense has been a standout component of their team. They have allowed only 303 points, ranking 2nd in the league, showcasing their ability to limit opponents’ scoring. Additionally, they have been effective in creating turnovers, with 13 interceptions, ranking 7th.

Philadelphia’s ability to recover fumbles has been noteworthy as well, securing 13 recoveries and ranking 3rd in the league. Their overall defensive strategy has limited opponents to 4732 total yards, the best in the league.

Recent Game Highlights

The Eagles recently secured a 20-17 victory against the Kansas City Chiefs at Arrowhead Stadium. Saquon Barkley led the rushing attack with 88 yards and a touchdown. Jalen Hurts completed 15 passes for 101 yards, contributing to the team’s overall performance.

In their season opener, the Eagles edged out the Dallas Cowboys 24-20 at Lincoln Financial Field. Again, Saquon Barkley was crucial with 60 rushing yards and a touchdown, while Jalen Hurts threw for 152 yards. The team demonstrated resilience in both games, setting a positive tone for the season.

Injury Concerns

Injuries remain a concern for the Eagles, with key players like Dallas Goedert and Will Shipley listed as questionable for upcoming games. The team will also be without Nakobe Dean and Johnny Wilson, both placed on the injured reserve list. This could impact their depth, especially on offense and special teams.

Team Betting Trends

  • SU – All Games (REG): Last 15 REG Games (2024–2025) → 14-1 (93.3%)
  • ATS – All Games (REG): Last 15 REG Games (2024–2025) → 14-1 (93.3%)
  • SU – Home Games (REG): Last 8 REG Games (2024–2025) → 8-0 (100.0%)
  • SU – As Favorite (REG): Last 13 REG Games (2024–2025) → 12-1 (92.3%)
  • ATS – As Favorite (REG): Last 13 REG Games (2024–2025) → 12-1 (92.3%)
  • SU – After Win (REG): Last 13 REG Games (2024–2025) → 12-1 (92.3%)
  • ATS – After Win (REG): Last 13 REG Games (2024–2025) → 12-1 (92.3%)
  • ATS – Away Games (REG): Last 7 REG Games (2024–2025) → 7-0 (100.0%)
  • SU – Totals ≤ 42 (REG): Last 4 REG Games (2024) → 4-0 (100.0%)
  • ATS – Totals ≤ 42 (REG): Last 4 REG Games (2024) → 4-0 (100.0%)

The Rams are Ready: Los Angeles Rams Preview for Upcoming Game

Team Overview

The Los Angeles Rams have started their 2025 season strong with a 2-0 record. They secured victories over the Tennessee Titans and Houston Texans, displaying a well-rounded performance on both sides of the ball. Heading into their next game against the Philadelphia Eagles, the Rams are 3.5-point underdogs.

The Rams’ offense has been efficient, scoring 367 points in the 2024 season, ranking 19th overall. Their passing game is notably strong, with 3,868 yards last season, ranking 10th in the league. However, their rushing attack ranks 23rd with 1,765 yards, indicating a need for improvement in that area.

Offensive Leaders

Quarterback Matthew Stafford has been a standout performer for the Rams, leading the league in passing yards with 543 over the first two games. He has thrown three touchdowns and only one interception, showcasing his ability to manage the game effectively.

Wide receiver Puka Nacua has also been a crucial target for Stafford, leading the league with 18 receptions for 221 yards. Meanwhile, Davante Adams contributes significantly with 157 receiving yards and one touchdown, providing a reliable option in the passing game.

Defensive Strength

Defensively, the Rams have allowed 386 points in the 2024 season, placing them 16th in the league. They have been successful at pressuring opposing quarterbacks, recording 38 sacks, which ranks 11th overall.

The Rams’ secondary has been effective, with 13 interceptions, ranking 7th in the league. Safety Kam Curl has been a pivotal player, contributing to the team’s success with consistent performances.

Injury Report

Currently, the Rams face some injury challenges with key players sidelined. Ahkello Witherspoon is out due to a shoulder injury, and Keir Thomas will miss the entire season with an undisclosed injury.

Additionally, tight end Colby Parkinson and guard Steve Avila are questionable for Week 3, which could impact the team’s offensive depth. The Rams will need to adapt and rely on their depth to navigate these injuries.

Team Betting Trends

  • SU – As Favorite (REG): Last 6 REG Games (2024–2025) → 6-0 (100.0%)
  • ATS – As Favorite (REG): Last 6 REG Games (2024–2025) → 6-0 (100.0%)
  • SU – Away Games (REG): Last 6 REG Games (2024–2025) → 6-0 (100.0%)
  • ATS – Away Games (REG): Last 6 REG Games (2024–2025) → 6-0 (100.0%)
  • SU – After Loss (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
  • ATS – After Loss (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)

As the Rams prepare for their upcoming game against the Eagles, their recent performance and betting trends indicate a strong potential for success. With their current form and the leadership of key players, the Rams are poised to compete effectively against Philadelphia.

Eagles vs Rams Prediction: Over 44.5

This matchup between the Philadelphia Eagles and Los Angeles Rams presents an intriguing case for the over. The Eagles have shown offensive proficiency, scoring 463 points last season, ranking 7th in the NFL. Their strong rushing attack, ranked 2nd last season, pairs well against a Rams defense that allowed 5998 yards, ranked 26th.

On the other hand, the Rams, under Sean McVay, have started the 2025 season with a perfect 2-0 record. Their offense ranked 19th in scoring last year, with a top 10 passing attack. This combination suggests they can put points on the board against the Eagles.

Historically, games between these two teams have seen high scores, with the last two matchups exceeding 44.5 points. Given the offensive capabilities and previous high-scoring games, the over 44.5 appears to be a solid pick.

The weather at Lincoln Financial Field is expected to be mild, with broken clouds and a light breeze, ideal for offenses to operate smoothly. Factoring in these conditions, a projected final score of Eagles 28 – Rams 24 supports the over.

  • Eagles vs Rams Prediction: Over 44.5
  • Eagles vs Rams Score: Eagles 28 – Rams 24
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