The Indianapolis Colts will host the Arizona Cardinals at Lucas Oil Stadium in Week 6 of the 2025 NFL season. This Sunday afternoon game, scheduled for October 12th at 1:00 PM, will be aired on FOX. With clear skies expected, the retractable roof ensures minimal weather impact on the game.
Heading into this matchup, the Colts boast a strong start to the season with a 4-1 record, including an impressive 3-0 home record. The Cardinals, led by head coach Jonathan Gannon, have had a challenging start with a 2-3 record and are looking to improve their 1-1 road performance. This game will be a test of strategies and execution as both teams seek to solidify their standings.
In recent games, the Colts have shown dominance at home, evident from their 40-6 victory over the Las Vegas Raiders. On the other hand, the Cardinals are coming off a narrow 22-21 loss to the Tennessee Titans, highlighting their potential for tight contests. This matchup will feature contrasting styles, with both teams aiming to capitalize on their strengths.
Colts vs Cardinals At a Glance
- Game Location: Lucas Oil Stadium in Indianapolis, IN USA
- Game Date & Time: Sunday, October 12, 2025 at 1:00 PM
- TV Channel: FOX
- Weather: Clear Sky with cool temperatures
- Cardinals Record: 2-3-0 this season
- Colts Record: 4-1-0 this season
Indianapolis Colts: A Deep Dive into the Upcoming Game
Recent Performance and Key Players
The Indianapolis Colts are coming off an impressive 40-6 victory over the Las Vegas Raiders. Daniel Jones has been a standout, leading the league with 1290 passing yards and ranking first for his team in passing touchdowns. Jonathan Taylor continues to shine in the backfield, ranking first in both the league and his team with 480 rushing yards.
Tyler Warren has been a crucial part of the Colts’ offense with 307 receiving yards, placing him first on the team. Michael Pittman Jr. has also contributed significantly, securing four receiving touchdowns, ranking first for the Colts. These players will be key in maintaining their offensive momentum in the upcoming game.
Offensive and Defensive Stats
Offensively, the Colts have shown balanced play with a focus on rushing, ranking 8th in the league with 2331 rushing yards last season. Their passing game, however, ranks 25th, indicating room for improvement. On defense, the team ranks 13th in sacks with 36, while their ability to force turnovers has been a strength, ranking 4th in interceptions.
The Colts’ defense has had challenges, conceding 427 points and ranking 23rd in opponent scores. However, they have managed to recover 10 fumbles, ranking 5th. Improving their defensive yardage allowed, which ranks 29th, will be crucial for their success.
Recent Game Analysis
In their recent win against the Raiders, the Colts excelled in passing with 221 yards and secured 24 first downs. Their defensive prowess was evident, as they allowed only 6 points and forced two interceptions. Jonathan Taylor’s performance, with three rushing touchdowns, was a highlight of the game.
Against the Rams, despite the 27-20 loss, the Colts showed resilience with 248 passing yards. However, turnovers were an issue, with two interceptions and two fumbles. Addressing these mistakes will be vital to avoid similar outcomes in future games.
Betting Trends
- SU – Home Games (REG): Last 5 REG Games (2024–2025) → 5-0 (100.0%)
- ATS – Home Games (REG): Last 5 REG Games (2024–2025) → 5-0 (100.0%)
- SU – After Loss (REG): Last 5 REG Games (2024–2025) → 5-0 (100.0%)
- SU – As Favorite (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
- ATS – As Favorite (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
- ATS – After Loss (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
- SU – All Games (REG): Last 6 REG Games (2024–2025) → 5-1 (83.3%)
- ATS – All Games (REG): Last 6 REG Games (2024–2025) → 5-1 (83.3%)
- O/U – Away Games (REG): Last 6 REG Games (2024–2025) → 5-1 (83.3%)
- O/U – After Loss (REG): Last 6 REG Games (2024–2025) → 5-1 (83.3%)
Arizona Cardinals Prepare for the Indianapolis Challenge
Recent Performance Overview
The Arizona Cardinals are heading into their Week 6 game against the Indianapolis Colts with some recent struggles. Their last game saw them narrowly lose to the Tennessee Titans 22-21, despite outperforming in rushing yards with 168 to the Titans’ 78. The Cardinals have suffered a string of close losses, highlighting their competitive nature but also their need to close out games more effectively.
In Week 4, they faced the Seattle Seahawks and lost 23-20. Despite strong defensive performances, including forcing two turnovers, the Cardinals couldn’t secure the win. Kyler Murray’s two interceptions in that game were a significant factor in the defeat.
Offensive Insights
Kyler Murray has been a central figure for the Cardinals, with 962 passing yards and six touchdowns in five games. While his passing yards rank him 18th league-wide, he leads the team in offensive production. Marvin Harrison Jr. has been a standout receiver, amassing 306 receiving yards and two touchdowns, providing a reliable target for Murray.
On the ground, the Cardinals have shown potential, ranking 7th in rushing yards with 2,451 last season. However, injuries have taken a toll, with James Conner and Trey Benson both out. This puts more pressure on players like Michael Carter and Emari Demercado to step up.
Defensive Strengths
Defensively, the Cardinals have been strong in certain areas, ranking 8th in sacks with 41 last season. This highlights their ability to apply pressure on opposing quarterbacks. They’ve also been efficient in recovering fumbles, ranking 7th in this category.
However, they have room for improvement in limiting opponent offensive yards, as they rank 21st in this area. Dadrion Taylor-Demerson and Budda Baker have been key players in the secondary, contributing to the team’s ability to intercept passes.
Team Betting Trends
- O/U – As Favorite (REG): Last 7 REG Games (2024–2025) → 6-1 (85.7%)
- O/U – Home Games (REG): Last 6 REG Games (2024–2025) → 5-1 (83.3%)
- SU – As Favorite (REG): Last 4 REG Games (2024–2025) → 3-1 (75.0%)
- O/U – After Loss (REG): Last 6 REG Games (2024–2025) → 4-2 (66.7%)
- SU – Home Games (REG): Last 8 REG Games (2024–2025) → 5-3 (62.5%)
- O/U – All Games (REG): Last 10 REG Games (2024–2025) → 6-4 (60.0%)
- ATS – Away Games (REG): Last 3 REG Games (2024–2025) → 2-1 (66.7%)
- SU – After Win (REG): Last 3 REG Games (2025) → 2-1 (66.7%)
- ATS – After Win (REG): Last 3 REG Games (2025) → 2-1 (66.7%)
- SU – All Games (REG): Last 15 REG Games (2024–2025) → 7-8 (46.7%)
- ATS – Home Games (REG): Last 8 REG Games (2024–2025) → 4-4 (50.0%)
- ATS – All Games (REG): Last 6 REG Games (2024–2025) → 3-3 (50.0%)
- ATS – As Favorite (REG): Last 6 REG Games (2024–2025) → 3-3 (50.0%)
- O/U – After Win (REG): Last 4 REG Games (2024–2025) → 2-2 (50.0%)
- ATS – As Underdog (REG): Last 5 REG Games (2024–2025) → 2-3 (40.0%)
- SU – After Loss (REG): Last 5 REG Games (2024–2025) → 2-3 (40.0%)
- ATS – After Loss (REG): Last 5 REG Games (2024–2025) → 2-3 (40.0%)
- SU – As Underdog (REG): Last 6 REG Games (2024–2025) → 2-4 (33.3%)
- SU – Away Games (REG): Last 3 REG Games (2024–2025) → 1-2 (33.3%)
- O/U – Away Games (REG): Last 7 REG Games (2024–2025) → 2-5 (28.6%)
Colts vs Cardinals Prediction: Over 47.5
The Indianapolis Colts have been performing well this season, particularly at home where they are undefeated. Their offense, ranked 16th last season, combined with the Cardinals’ 12th ranked offense, suggests a potential high-scoring game. Additionally, the Colts’ defense ranked 23rd in opponent scoring, indicating the Cardinals could take advantage and put up points.
Weather conditions are expected to have minimal impact, as the game is being played in Lucas Oil Stadium with a retractable roof. The clear sky forecast further supports optimal playing conditions for both offenses. These conditions typically favor offensive productivity, increasing the likelihood of a higher score.
Looking at past trends, the Colts have a tendency to perform well in terms of the over, with a 9-4 record in their last 13 regular season games. Similarly, the Cardinals have also shown offensive capabilities that can contribute to a high-scoring affair. This aligns with the expectations for a game total surpassing the set 47.5 points.
Given the combination of offensive potential and defensive vulnerabilities, the over is the favorable pick for this game. Expect a competitive clash with both teams likely finding the end zone multiple times. Based on these factors, a projected final score would see the Colts winning 30-24.
- Colts vs Cardinals Prediction: Over 47.5
- Colts vs Cardinals Score: Colts 30 – Cardinals 24
