CFB Game Prediction

Colorado vs BYU Prediction & Betting Tips for CFB Week 5 on 9/27/2025

Want our best Colorado vs BYU prediction for 9/27/25? Get our College Football betting tip as the BYU travel to Colorado in Week 5 on 9/27/25 at Folsom Field, in Colorado. Knup Sports has your free CFB pick!

The BYU Cougars, currently ranked #25 in the AP Poll and #24 in the Coaches Poll, travel to Boulder for a Week 5 game against the Colorado Buffaloes. Having started the season with an impressive 3-0 record, the Cougars aim to maintain their unbeaten streak. Their recent victory over East Carolina, 34-13, highlights their strong start this season.

On the other hand, the Colorado Buffaloes enter the game with a 2-2 record, showcasing a mixed performance with a recent 37-20 victory over Wyoming. Playing at home in Folsom Field, Colorado holds a 2-1 home record this season. The Buffaloes look to leverage their home field advantage to overcome a challenging BYU team.

With both teams playing in the Big 12 Conference, this game provides an opportunity for Colorado to improve upon their 0-1 conference record. The game is set to be broadcast on ESPN at 10:15 PM, under the night lights of Boulder. The game odds currently favor BYU with a -6.5 spread, indicating high expectations for the visiting team.

Colorado vs BYU At a Glance

  • Game Venue: Folsom Field in Boulder, CO
  • Game Date and Time: Saturday, September 27, 2025, at 10:15 PM
  • TV Broadcast: ESPN
  • BYU Cougars Record: 3-0 this season
  • Colorado Buffaloes Record: 2-2 this season
  • Moneyline Odds: BYU -242, Colorado +198

Colorado Buffaloes Set for a Showdown: Analyzing the Upcoming Game

Team Overview

The Colorado Buffaloes are coming off a strong 37-20 victory against the Wyoming Cowboys, showing their ability to perform at home in Boulder, CO. This win boosts their confidence as they prepare to meet the BYU Cougars in their next home game.

With a 6.5-point underdog status for this upcoming game, the Buffaloes have demonstrated resilience in overcoming such odds. Their recent performance indicates a team finding its rhythm as the season progresses.

Offensive Performance

Colorado’s offense has been productive this season, accumulating 108 points, ranking them 48th in the nation. Passing yards have been a key component of their strategy, with 934 yards ranked 54th, showcasing their air attack capabilities.

Their rushing attack, however, needs improvement, with only 570 rushing yards, ranking 74th. The Buffaloes’ ability to secure first downs, ranking 30th, is a testament to their offensive consistency.

Defensive Strengths

Defensively, Colorado has allowed 90 points, placing them 60th in the rankings. Their pass rush has been effective, with seven sacks positioning them 11th nationally.

Turnovers have been a bright spot, with two interceptions and three fumbles recovered, both ranked 3rd. This opportunistic defense could play a crucial role against the Cougars.

Key Players to Watch

Quarterback Kaidon Salter has been the standout performer for Colorado, leading with 565 passing yards and four touchdowns. His performance will be pivotal in the upcoming game.

On the ground, Simeon Price and Micah Welch lead the rushing attack, though both need to improve to provide a balanced offensive threat. Wide receiver Sincere Brown has been a reliable target, tallying 203 receiving yards.

Injury Report

Several players are questionable, including Samuel Okunlola and Tawfiq Thomas, both dealing with undisclosed injuries. Their availability could impact Colorado’s defensive performance.

With multiple key players on the injury list, the Buffaloes’ depth will be tested against a competitive BYU team.

Colorado Betting Trends

  • SU – As Favorite: 16-3 (84.2%) over the last 19 games.
  • SU – After Loss: 6-0 (100.0%) in the last 6 games.
  • ATS – Totals ≥ 50: 8-2 (80.0%) in the last 10 games.
  • SU – Home Games: 5-1 (83.3%) in the last 6 games.
  • ATS – As Favorite: 7-2 (77.8%) in the last 9 games.

BYU Cougars Set to Tackle the Colorado Buffaloes

Team Overview

The BYU Cougars have been consistent this season, with a strong record as they prepare to meet the Colorado Buffaloes. Their 2025 campaign shows a strong offensive and defensive line-up, which has contributed to their success so far.

BYU is known for its effective rushing game, ranking 32nd in the nation with 798 rushing yards. This strength will be crucial as they take on Colorado away from home.

Offensive Strengths

While their passing game has not been as dominant, ranking 118th with 559 yards, BYU’s ground game has been a key factor in their offensive strategy. They rank 31st in points for, with 130 points scored in the current season.

Bear Bachmeier, leading the quarterback position, has contributed significantly with 518 passing yards and four touchdowns. His performance will be pivotal in maintaining offensive momentum against Colorado.

Defensive Edge

The Cougars’ defense has been impressive, ranking first in points against with only 16 points allowed this season. Their ability to limit opponents’ scoring opportunities has been a major asset.

With a sack tally ranking 11th and interceptions ranking 5th, BYU’s defensive line is well-prepared to disrupt the Buffaloes’ offensive efforts. Their defensive prowess is expected to play a crucial role in the upcoming game.

Recent Performances

In their recent outings, BYU has demonstrated their capability to dominate on the field. Their recent 34-13 win over East Carolina showcased their balanced approach on both sides of the ball.

Maintaining a solid track record, the Cougars have shown resilience in both home and away games, further boosting their confidence heading into the clash with Colorado.

BYU Betting Trends

  • SU – As Favorite: Last 15 Games (2022–2025) → 14-1 (93.3%)
  • SU – After Win: Last 12 Games (2024–2025) → 11-1 (91.7%)
  • ATS – All Games: Last 3 Games (2025) → 3-0 (100.0%)
  • ATS – As Favorite: Last 3 Games (2025) → 3-0 (100.0%)
  • SU – Away Games: Last 7 Games (2024–2025) → 6-1 (85.7%)

Colorado vs BYU Prediction: Colorado +6.5

BYU comes into this game with a strong 3-0 record and a solid defense, allowing just 16 points per game, which ranks first nationally. However, playing on the road in Boulder at night presents a unique challenge, especially against a Colorado team that’s 2-1 at home this season.

Colorado’s offense has been efficient, ranking 48th in points scored with 108 in four games, and they possess a significant home-field advantage. Despite a 2-2 record, their performance after a win has been impressive, as they have covered the spread in 66.7% of games following a victory over the past two seasons.

Given the Colorado Buffaloes’ historical success against the spread as underdogs, with an 8-4 ATS record in the last two years, they look poised to cover the +6.5 spread. The Buffaloes’ recent performance, including a decisive 37-20 win over Wyoming, further supports this prediction.

Looking at past head-to-heads, BYU defeated Colorado 36-14 in the last meeting, but Colorado’s improvement and favorable betting trends make them a good pick. Expect a closer game this time, with the Buffaloes keeping it tight.

  • Colorado vs BYU Prediction: Colorado +6.5
  • Colorado vs BYU Score: BYU 27 – Colorado 24
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