MLB Game Prediction

Cleveland Guardians vs Chicago White Sox Prediction & Betting Tips for 9/14/2025

Want our best Cleveland Guardians vs Chicago White Sox prediction for 9/14/25? Get our MLB betting tip as the White Sox travel to the Guardians on 9/14/25 at Progressive Field, in Cleveland. Knup Sports has your free pick!

The Chicago White Sox, with a season record of 57-92, are looking to break their two-game losing streak as they travel to face the Cleveland Guardians. Managed by Will Venable, the White Sox have had a challenging season, ranked fifth in the AL Central. Their recent performance shows some promise, however, with a 6-4 record in their last ten games.

On the other hand, the Cleveland Guardians hold a more favorable position in the standings with a 77-71 record, placing them second in the AL Central. Under the guidance of manager Stephen Vogt, the Guardians are currently on a three-game winning streak and have been impressive in their last ten games with an 8-2 record. The game is set to take place at Progressive Field, where the Guardians have maintained a strong home record.

The matchup is scheduled for Sunday afternoon, September 14, 2025, at 1:40 PM, and will be broadcast on CHSN. Weather conditions are expected to be ideal for baseball, with a warm day and clear skies. With the Guardians favored at -170 and the White Sox at +143 on the moneyline, fans can expect an exciting game at Progressive Field.

Guardians vs White Sox At a Glance

  • Game Location: Progressive Field in Cleveland, OH.
  • Weather: Clear skies with a light breeze.
  • Away Team Record: Chicago White Sox hold a 57-92 record.
  • Home Team Record: Cleveland Guardians have a 77-71 record.
  • Game Odds: Guardians are favored with a moneyline of -170.
  • TV Broadcast: The game will be shown on CHSN.

Guardians Gear Up for Showdown Against White Sox

Chicago White Sox: Team Overview

The Chicago White Sox are set to take on the Cleveland Guardians, bringing a record that reflects their challenges this season. Their performance has been inconsistent, highlighted by a mix of highs and lows throughout the year.

Offensively, the White Sox have shown some power with 153 home runs, placing them 19th in the league. However, their batting average of .225 ranks them 23rd, indicating struggles in maintaining consistency at the plate.

Key Players to Watch

Yoendrys Gómez will start on the mound for the White Sox, bringing a 5.05 ERA and a 1.51 WHIP into the game. With a 3-2 win-loss record, Gómez’s performance will be crucial for the White Sox’s chances.

Offensively, the team will look to their power hitters to provide the necessary firepower. With a ranking of 19th in home runs, the White Sox hitters need to capitalize on any opportunities to make an impact.

White Sox Team Hitting and Pitching Insights

While their home run tally is decent, the White Sox’s on-base percentage of .294 ranks 22nd, indicating issues with getting players on base. This could be a key area to address against the Guardians’ pitching staff.

On the pitching side, the White Sox have given up 156 home runs, which ranks 5th in the league. This statistic highlights a potential vulnerability that the Guardians’ batters could exploit.

White Sox Betting Trends

  • SU Last 5 Games: 2-3
  • Runline Last 5: 3-2
  • O/U Last 5: 1-4
  • SU as Underdog: 18-30
  • Runline as Underdog: 24-24
  • O/U as Underdog: 20-28

Game Outlook

The White Sox’s success may depend on their ability to overcome the Guardians’ robust pitching lineup. With a team ERA of 3.81, the Guardians rank 8th in the league, posing a significant challenge for the White Sox batters.

For the White Sox, capitalizing on opportunities and tightening up their pitching will be essential to securing a victory. As the game approaches, both teams will aim to leverage their strengths and address their weaknesses for a competitive showdown.

Chicago White Sox Set Sights on Cleveland Guardians Showdown

Away Team Overview

The Chicago White Sox are entering this game with a .235 batting average, placing them 20th in the league. Their on-base percentage stands at .302, also ranking 21st. Despite these challenges, they have managed to hit 150 home runs this season.

In the previous matchup against the Cleveland Guardians, the White Sox managed only one hit with runners in scoring position. Lenyn Sosa was responsible for this hit, highlighting his key role in the lineup. The team will need to capitalize on more opportunities to improve their offensive output.

Key Players to Watch

Miguel Vargas, the team’s third baseman, has played in 126 games this season, recording a .229 batting average. With 14 home runs and 52 RBIs, he remains a significant contributor to the White Sox offense. Vargas ranks third on the team in home runs and second in RBIs.

Lenyn Sosa leads the team with 20 home runs, showcasing his power at the plate. His .263 batting average and 68 RBIs make him an essential asset in the lineup. Sosa’s performance will be crucial for the White Sox as they aim to increase their run production.

Pitching Staff Insights

Yoendrys Gómez will take the mound for the White Sox, entering the game with a 5.05 ERA and a 1.51 WHIP. His record stands at 3-2, and he will be tasked with keeping the Guardians’ offense in check. The White Sox pitching staff has given up 170 home runs this season, ranking 10th in the league.

Gómez will need to be cautious with his pitches, as the Guardians have shown their ability to hit for power. The White Sox bullpen, with 21 blown saves, has struggled in late-game situations. They must find a way to close out games effectively to secure a win.

Team Betting Trends

  • SU in Away Games: 25-49 (33.8%)
  • Runline in Away Games: 43-31 (58.1%)
  • O/U in Away Games: 30-44 (40.5%)

The White Sox have a record of 1-2 straight up as a favorite this season. They have shown resilience on the runline, especially as underdogs, with an impressive 87-59 record. However, their performance on the road has been inconsistent, as reflected by their 25-49 away game record.

Guardians vs White Sox Prediction: Guardians -170

The Cleveland Guardians come into this game with a significant advantage, boasting a strong recent form of 8-2 in their last ten games. Their home performance has been solid throughout the season, and they are currently riding a three-game winning streak. Facing the White Sox, who are struggling at 57-92 and last in their division, the Guardians have been dominant in their head-to-head matchups this season, holding an 8-2 record against Chicago.

Starting pitcher Slade Cecconi for the Guardians has been reliable with a 4.45 ERA and a WHIP of 1.25. In contrast, the White Sox’s Yoendrys Gómez has an ERA of 5.05 and a higher WHIP of 1.51, suggesting potential struggles against a Cleveland lineup that has performed well recently. Additionally, the Guardians’ home record of 40-34 further strengthens their position in this game.

Given the Guardians’ superior form, both overall and in their head-to-head clashes with the White Sox, the odds of -170 for Cleveland are appealing despite being the favorites. With their consistent performance and home field advantage, they are poised to continue their dominance over the White Sox in this encounter.

Anticipating a relatively low-scoring game, the Guardians’ recent trend of games leaning towards the under suggests a final score of 4-2 in favor of Cleveland. This outcome aligns with their previous victories over Chicago, particularly at home.

  • Guardians vs White Sox Prediction: Guardians -170
  • Guardians vs White Sox Score: Guardians 4 – White Sox 2
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