MLB Game Prediction

Chicago Cubs vs St. Louis Cardinals Prediction & Betting Tips for 9/28/2025

Want our best Chicago Cubs vs St. Louis Cardinals prediction for 9/28/25? Get our MLB betting tip as the Cardinals travel to the Cubs on 9/28/25 at Wrigley Field, in Chicago. Knup Sports has your free pick!

The St. Louis Cardinals, currently holding a 78-83 record, are set to take on the Chicago Cubs at Wrigley Field in an NL Central showdown. The Cardinals are looking to break a three-game losing streak as they head into this afternoon contest. With a 5-5 record over their last 10 games, they are in 4th place in the division, managed by Oliver Marmol.

On the other side, the Chicago Cubs, boasting a 91-70 record, aim to continue their winning momentum at home. Sitting in 2nd place in the division, the Cubs have won their last two games and look to improve their recent 4-6 streak in the last 10 outings. Managed by Craig Counsell, the Cubs have been dominant at home with a 49-31 record this season.

The game, starting at 3:20 PM on Sunday, September 28, 2025, will be played under clear skies with a mild breeze. The Cubs are favored in the betting odds with a moneyline of -170, while the Cardinals are at +141. Fans can tune in to FDSMW to catch the live action from Chicago.

Cubs vs Cardinals At a Glance

  • Game Location: Wrigley Field in Chicago, IL
  • Cardinals Current Record: 78-83, 4th in NL Central
  • Cubs Current Record: 91-70, 2nd in NL Central
  • Weather Forecast: Clear sky, mild day with a light breeze
  • Game Odds: Cubs favored with -170 moneyline; Cardinals at +141
  • TV Broadcast: FDSMW

Cubs Prepare for Crucial Game: Analyzing the Opponent

Team Overview

The St. Louis Cardinals head into their next game against the Chicago Cubs with a respectable 2025 season record. Their current standing reflects a solid overall performance, with standout moments throughout the season. This upcoming game is critical as the Cardinals aim to maintain their momentum.

The Cardinals have demonstrated a balanced approach, both offensively and defensively. Their ability to adapt and perform under pressure will be vital as they meet the Cubs at Wrigley Field.

Key Players to Watch

Among the key players for the Cardinals, the spotlight will be on Kyle Leahy, who has been instrumental with his pitching prowess. With an ERA of 3.18, Leahy’s consistency on the mound is expected to play a significant role in their upcoming game.

Offensively, the Cardinals rely on their lineup’s depth to produce runs. Maintaining their hitting performance against the Cubs’ pitchers will be crucial for their success in the game.

Recent Team Performance

The Cardinals have shown resilience in their recent games, contributing to their solid position in the standings. Their recent performances have showcased both strengths and areas needing improvement, providing insights into potential strategies against the Cubs.

Analyzing past games, the Cardinals will need to address any shortcomings in their offensive and defensive strategies to gain an edge over their competitors.

Pitching Strategy

Starting pitcher Kyle Leahy will be a key player for the Cardinals, bringing his impressive stats into the game. His ability to manage the Cubs’ hitters could determine the outcome of the game.

The Cardinals’ bullpen will also be under scrutiny, as they aim to effectively support their starter and maintain control throughout the game.

Team Betting Trends

  • SU in Away Games: 42-39 (51.9%)
  • Runline in Away Games: 38-43 (46.9%)
  • O/U in Away Games: 36-45 (44.4%)

Cardinals Seek Redemption: A Close Look at Their Upcoming Game

Overview of the Cardinals’ Performance

The St. Louis Cardinals have had a challenging stretch, with recent losses against the Chicago Cubs and the San Francisco Giants. Their offense has shown potential, but they have struggled to convert hits into wins. As they prepare for their next game, they aim to reverse this trend.

Despite recent setbacks, the Cardinals’ lineup includes several high-performing players. Key hitters like Brendan Donovan and Iván Herrera will be essential as they strive to regain momentum.

Key Players to Watch

Brendan Donovan, with a batting average of .287 and ten home runs, stands out as a consistent performer. His ability to get on base and drive in runs is vital for the team’s success. Donovan’s recent performance has been a bright spot amid the team’s struggles.

Iván Herrera, serving as the designated hitter, boasts a .286 average and 19 home runs. His on-base percentage of .377 indicates his knack for drawing walks and finding ways to reach base, contributing to the team’s offensive efforts.

Alec Burleson is another player to keep an eye on, holding a .290 average and 18 home runs. As one of the top contributors, his performance will be crucial in the Cardinals’ attempt to outscore their opponents.

Pitching Concerns and Expectations

Kyle Leahy is set to start on the mound for the Cardinals, bringing a solid 3.18 ERA and a 1.26 WHIP. His performance will be pivotal in containing the Cubs’ offense and providing a chance for the Cardinals to secure a win.

With Zack Thompson on the injured list, the Cardinals’ pitching depth is tested. This presents an opportunity for other pitchers to step up and fill the void left by Thompson’s absence.

Betting Trends for the Cardinals

  • SU Last 3 Games: 0-3 (0.0%)
  • Runline as Underdog: 56-38 (59.6%)
  • O/U in Away Games: 42-38 (52.5%)
  • SU vs Division Opponents: 37-32 (53.6%)
  • Runline when Scoring 5+: 53-17 (75.7%)

Cubs vs Cardinals Prediction: Cubs -170

The Chicago Cubs head into their final regular-season game with momentum, having won their last two games against the St. Louis Cardinals convincingly. They boast a solid home record of 49-31 and have dominated the Cardinals in recent matchups, outscoring them by an average margin of 4.5 runs in their last ten encounters. Given these factors, the Cubs are well-positioned to secure another win at Wrigley Field.

Javier Assad will be taking the mound for the Cubs, and while his season ERA of 4.26 is modest, the Cubs’ offensive firepower could prove to be the difference-maker. The Cardinals, on the other hand, have struggled with consistency, as indicated by their three-game losing streak and poor road record of 34-46. The Cubs’ recent offensive surge, highlighted by players like Michael Busch and Seiya Suzuki, further tilts the odds in their favor.

Given the Cubs’ recent performances and their superior head-to-head record against the Cardinals, the -170 moneyline for Chicago appears to be a solid pick. Despite the absence of pitcher Cade Horton, the Cubs have depth in their roster to compensate, and the potential for offensive fireworks at home remains high. As the Cubs prepare for their postseason run, they will likely look to make a statement in this game.

The Cardinals’ inconsistent season and current losing streak make them a risky bet, especially against a Cubs team that has dominated their matchups this year. With both teams fielding less experienced pitchers, the Cubs’ offensive strength and home advantage should help them secure a comfortable victory. Expect a final scoreline of Cubs 7 – Cardinals 3, as they wrap up their regular season on a high note.

  • Cubs vs Cardinals Prediction: Cubs -170
  • Cubs vs Cardinals Score: Cubs 7 – Cardinals 3
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