The New Orleans Saints are set to visit the Buffalo Bills at Highmark Stadium for a Week 4 matchup in the 2025 NFL season. The game kicks off on Sunday, September 28, 2025, at 1:00 PM and will be broadcast on CBS. Weather conditions for the game remain unspecified, but the outdoor setting could play a factor. The Saints, led by Head Coach Kellen Moore, are still seeking their first win of the season, holding a 0-3 record. Their most recent game ended in a 44-13 defeat against the Seattle Seahawks. With the Saints struggling on both sides of the ball, they face a tough challenge against a dominant Bills team. The Buffalo Bills, under Head Coach Sean McDermott, have been impressive with a perfect 3-0 record. They come off a 31-21 victory over the Miami Dolphins and are undefeated at home this season. With a strong offensive unit and solid defense, the Bills are heavy favorites with a moneyline of -1708 and a spread of -16.5 points.
Bills vs Saints At a Glance
- Game Location: Highmark Stadium in Orchard Park, NY
- Game Date & Time: Sunday, September 28, 2025 at 1:00 PM
- TV Broadcast: CBS
- Weather Conditions: No specific description available
- Saints Record: 0-3-0
- Bills Record: 3-0-0
Buffalo Bills: A Dominant Force Awaiting New Challenges
Team Offense Overview
The Buffalo Bills are currently riding high on the offensive charts with a second-place ranking in total points scored for the 2024 regular season, amassing a total of 525 points. Their passing game has been formidable as well, with 3,875 passing yards, earning them the 9th spot in the league.
On the ground, the Bills have not been lacking either, ranking 9th with 2,230 rushing yards. They have achieved 360 first downs, showcasing their ability to sustain drives and maintain possession effectively.
Defensive Strengths
The Bills’ defense has held opponents to 368 points, placing them 11th in the league for opponent scoring. They have also been effective in disrupting opposing offenses, recording 39 sacks and ranking 10th in that category.
Turnovers have been a crucial part of their defensive strategy, as evidenced by their 16 opponent interceptions and 16 fumbles recovered, the latter of which ranks them first in the league. Their defensive unit has proven to be a key component of their overall success this season.
Recent Performances
The Bills have started the 2025 regular season strong with a perfect 3-0 record. In their most recent game against the Miami Dolphins, they secured a 31-21 victory, outpacing the Dolphins in both passing and rushing yards.
Earlier victories against the New York Jets and Baltimore Ravens also showcased their balanced offensive attack and resilient defense. Josh Allen has been instrumental in these wins, providing consistent performances under center.
Key Players to Watch
Quarterback Josh Allen has been leading the charge with 755 passing yards and 5 touchdowns over the first three games. His dual-threat capability has kept defenses on their toes.
Running back James Cook has also been a standout performer, accumulating 284 rushing yards and 4 touchdowns, making him a vital part of the Bills’ offensive scheme. Additionally, tight end Dalton Kincaid has proven to be a reliable target, with 151 receiving yards and 2 touchdowns.
Team Betting Trends
- SU – Home Games (REG): Last 8 REG Games (2024–2025) → 8-0 (100.0%)
- SU – All Games (REG): Last 15 REG Games (2024–2025) → 13-2 (86.7%)
- ATS – All Games (REG): Last 15 REG Games (2024–2025) → 13-2 (86.7%)
- SU – As Favorite (REG): Last 13 REG Games (2024–2025) → 11-2 (84.6%)
- ATS – As Favorite (REG): Last 13 REG Games (2024–2025) → 11-2 (84.6%)
- O/U – Totals ≥ 50 (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
New Orleans Saints: A Tough Road Ahead Against the Bills
Offensive Overview
The New Orleans Saints have struggled offensively this season, ranking 23rd in scoring with a total of 338 points. Their passing game has also been a point of concern, ranking 23rd with 3,488 yards. However, their rushing attack has been a bright spot, ranking 14th with 1,954 yards.
In their most recent game against the Seattle Seahawks, the Saints managed only 13 points. Quarterback Spencer Rattler threw for 218 yards, one touchdown, and one interception. The team’s leading rusher, Alvin Kamara, was limited to just 42 yards on the ground.
Defensive Standpoint
Defensively, the Saints rank 18th in opponent scoring, having allowed 398 points this season. Despite allowing a high number of yards, the team has been effective at pressuring quarterbacks with 39 sacks, ranking 10th. Their secondary has also been opportunistic with 14 interceptions, ranking 6th.
In the matchup against the Seahawks, the defense allowed 44 points, marking a challenging outing. Linebacker Pete Werner was active with 13 tackles, while the defensive line struggled to contain the Seahawks’ offense.
Key Players and Injuries
The Saints will rely heavily on key offensive players like Alvin Kamara, who has rushed for 186 yards and one touchdown this season. Wide receivers Chris Olave and Rashid Shaheed have been targets in the passing game, with Olave catching 23 passes for 165 yards.
Injuries have plagued the team, with several key players like Taysom Hill and Foster Moreau sidelined. The offensive line is also depleted, with multiple players on injured reserve, impacting their protection schemes.
Betting Trends
- O/U – All Games (REG): Last 4 REG Games (2024–2025) → 3-1 (75.0%)
- O/U – As Underdog (REG): Last 4 REG Games (2024–2025) → 3-1 (75.0%)
- O/U – After Loss (REG): Last 4 REG Games (2024–2025) → 3-1 (75.0%)
- O/U – Away Games (REG): Last 3 REG Games (2024–2025) → 2-1 (66.7%)
- SU – All Games (REG): Last 11 REG Games (2024–2025) → 3-8 (27.3%)
Upcoming Game Expectations
As the Saints prepare to take on the Buffalo Bills, they face a daunting challenge as 16.5-point underdogs. The Bills’ strong defense will test the Saints’ struggling offense. With a total set at 47.5 points, the game could be a tough battle for the Saints.
The Saints will need to find a way to break through the Bills’ defense and capitalize on scoring opportunities. Limiting turnovers and improving third-down conversions, where they rank 24th, will be crucial for their success.
Bills vs Saints Prediction: Over 47.5
The Buffalo Bills have shown offensive strength, ranking 2nd in scoring with 525 points last season. Their offensive prowess, combined with the Saints’ defensive struggles, could lead to a high-scoring game. The Bills have also hit the over in their last three home games.
New Orleans Saints are winless this season, but their offensive strategy under Head Coach Kellen Moore can still produce points. The Saints’ defensive weaknesses, especially against high-powered offenses like the Bills, suggest they might concede heavily. This scenario enhances the likelihood of the total exceeding 47.5 points.
Historically, games between the Bills and Saints have seen high scores, with their last two head-to-head encounters going over the 48.5 total. Given the current form and previous outcomes, the over is a favorable pick.
Considering Buffalo’s strong home record and their tendency to cover the spread, a predicted scoreline of Bills 38 – Saints 17 supports the over 47.5 total. The game conditions at Highmark Stadium could also favor the Bills’ offensive capabilities, contributing to a high-scoring contest.
- Bills vs Saints Prediction: Over 47.5
- Bills vs Saints Score: Bills 38 – Saints 17
