The Miami Dolphins will travel to Highmark Stadium to take on the Buffalo Bills in a Week 3 Thursday night game on September 18, 2025. The game, set to kick off at 8:15 PM, will be broadcast on AMZN. Fans can expect a pleasant viewing experience under a clear sky and a warm evening with a light breeze in Orchard Park, NY.
Currently, the Dolphins find themselves in a challenging position with a 0-2 record, having lost their previous games against the New England Patriots and the Indianapolis Colts. Under the guidance of head coach Mike McDaniel, the team aims to secure their first win of the season. Meanwhile, the Bills, led by head coach Sean McDermott, enter this game with a perfect 2-0 record, featuring notable victories over the New York Jets and the Baltimore Ravens.
According to the consensus odds, the Dolphins are considered significant underdogs with a moneyline of +571 and a spread of +12.5. Conversely, the Bills are seen as strong favorites with a moneyline of -809 and a spread of -12.5. The total points line is set at 49.5, hinting at a potentially high-scoring game between these AFC East rivals.
Bills vs Dolphins At a Glance
- Game Date and Time: Thursday, September 18, 2025 at 8:15 PM (Night Game)
- Stadium: Highmark Stadium in Orchard Park, NY USA — Outdoor Field
- Weather Forecast: Warm day with a light breeze, conditions described as ‘Clear Sky’
- TV Channel: AMZN
- Miami Dolphins Record: 0-2-0
- Buffalo Bills Record: 2-0-0
The Buffalo Bills’ Dynamic Offense Prepares for Miami Showdown
Offensive Performance
The Buffalo Bills have had an impressive offensive start to the 2025 season, scoring 525 points in their last regular season, ranking them 2nd in the league. Their passing attack has been robust, achieving 3,875 yards, which places them 9th. They also rank 9th in rushing with 2,230 yards, showcasing a balanced offensive strategy.
The Bills have successfully converted 44.1% of their third downs, ranking them 7th in the league. This efficiency has been a key factor in their ability to sustain drives and accumulate first downs, where they rank 6th with 360.
Defensive Strengths
Defensively, the Bills have been solid, allowing 368 points and ranking 11th in opponent scoring. Their ability to pressure the quarterback is evident with 39 sacks, placing them 10th in the league. The Bills’ secondary has also been effective, intercepting 16 passes, which ranks them 4th.
Additionally, the Bills’ defense has been opportunistic, leading the league with 16 fumbles recovered. They have allowed 5,806 opponent offensive yards, which positions them at 17th, showing room for improvement in yardage allowed.
Recent Game Performances
The Bills opened the 2025 season with a thrilling 41-40 win over the Baltimore Ravens at Highmark Stadium. Quarterback Josh Allen had a standout performance with 394 passing yards and two touchdowns. The following week, the Bills secured a 30-10 victory against the New York Jets, showcasing their defensive prowess by limiting the Jets to 54 passing yards.
Running back James Cook has been a key offensive contributor, accumulating 176 rushing yards and three touchdowns over the first two games. His performance against the Jets was notable, with 132 rushing yards and two touchdowns.
Injury Concerns
The Bills are facing several injury concerns heading into their game against the Miami Dolphins. Key players like Shaq Thompson, Matt Milano, and Ed Oliver are listed as questionable, which could impact their defensive capabilities. Additionally, the absence of kicker Tyler Bass, who is on injured reserve, may affect their special teams unit.
Team Betting Trends
- ATS – All Games (REG): Last 14 REG Games (2024–2025) → 13-1 (92.9%)
- SU – Home Games (REG): Last 7 REG Games (2024–2025) → 7-0 (100.0%)
- ATS – Home Games (REG): Last 7 REG Games (2024–2025) → 7-0 (100.0%)
- ATS – As Favorite (REG): Last 12 REG Games (2024–2025) → 11-1 (91.7%)
- ATS – After Win (REG): Last 11 REG Games (2024–2025) → 10-1 (90.9%)
- SU – All Games (REG): Last 14 REG Games (2024–2025) → 12-2 (85.7%)
The Dolphins’ Dive: Miami Heads to Buffalo
Offensive Struggles and Opportunities
The Miami Dolphins have faced challenges on offense this season, ranking 21st in scoring with a total of 345 points. Their passing game is slightly more effective, with 3737 passing yards placing them 15th in the league. The rushing attack, however, has been less impressive, ranking 20th with 1795 rushing yards.
First downs have been a somewhat bright spot for Miami, as they are ranked 12th with 345 first downs. However, their third down conversion rate is less consistent, placing them 21st in the league with a 36.3% success rate. This inconsistency has contributed to their recent difficulties in securing victories.
Defensive Performances and Challenges
Defensively, the Dolphins have shown some resilience, ranking 10th in opponent scoring with 364 points allowed. Their ability to generate sacks is also notable, with 35 sacks putting them in 14th place. The defense has been effective in forcing turnovers, ranking 10th in opponent passing interceptions with 10.
Fumbles recovered by the Dolphins’ defense are noteworthy, ranking 9th with six recoveries. Additionally, they have excelled in limiting opponent offensive yards, ranking 4th by allowing 5344 yards. These defensive efforts will be crucial as they face the Buffalo Bills.
Recent Game Analysis
In their recent game against the New England Patriots, the Dolphins struggled to keep up, losing 33-27. Miami’s offense managed 297 passing yards but only 61 rushing yards, highlighting an area in need of improvement. Turnovers were also an issue, with one interception and one fumble lost.
The Dolphins’ defense allowed 122 rushing yards and 211 passing yards to the Patriots. Despite these challenges, standout performances came from Tua Tagovailoa and Jaylen Waddle, who contributed significantly on offense. Jordyn Brooks and Bradley Chubb led the defensive efforts with one sack each.
Upcoming Challenges and Injuries
Looking ahead, the Dolphins will face the Buffalo Bills as 11.5-point underdogs. Injuries are a significant concern, with key players like Jaylen Waddle and Darren Waller listed as questionable. The Dolphins’ depth chart will be tested, particularly in the receiving and defensive back positions.
With several players on injured reserve, including Artie Burns and Alexander Mattison, Miami’s coaching staff must adjust strategies accordingly. The depth and resilience of the roster will be crucial in this challenging away game.
Team Betting Trends
- O/U – Home Games (REG): Last 6 REG Games (2024–2025) → 6-0 (100.0%)
- ATS – As Favorite (REG): Last 7 REG Games (2024–2025) → 6-1 (85.7%)
- O/U – As Favorite (REG): Last 6 REG Games (2024–2025) → 5-1 (83.3%)
- ATS – Home Games (REG): Last 6 REG Games (2024–2025) → 5-1 (83.3%)
- SU – As Favorite (REG): Last 5 REG Games (2024–2025) → 4-1 (80.0%)
- SU – Home Games (REG): Last 5 REG Games (2024–2025) → 4-1 (80.0%)
- O/U – After Loss (REG): Last 7 REG Games (2024–2025) → 5-2 (71.4%)
- O/U – All Games (REG): Last 13 REG Games (2024–2025) → 8-5 (61.5%)
- ATS – All Games (REG): Last 15 REG Games (2024–2025) → 8-7 (53.3%)
- SU – All Games (REG): Last 11 REG Games (2024–2025) → 6-5 (54.5%)
- O/U – As Underdog (REG): Last 3 REG Games (2024–2025) → 2-1 (66.7%)
- SU – Totals ≤ 42 (REG): Last 3 REG Games (2024) → 2-1 (66.7%)
- ATS – Totals ≤ 42 (REG): Last 3 REG Games (2024) → 2-1 (66.7%)
- ATS – After Loss (REG): Last 7 REG Games (2024–2025) → 4-3 (57.1%)
- SU – After Loss (REG): Last 5 REG Games (2024–2025) → 3-2 (60.0%)
- SU – After Win (REG): Last 6 REG Games (2024) → 3-3 (50.0%)
- ATS – After Win (REG): Last 6 REG Games (2024) → 3-3 (50.0%)
- O/U – After Win (REG): Last 6 REG Games (2024) → 3-3 (50.0%)
- SU – Away Games (REG): Last 9 REG Games (2024–2025) → 3-6 (33.3%)
- ATS – Away Games (REG): Last 9 REG Games (2024–2025) → 3-6 (33.3%)
Bills vs Dolphins Prediction: Bills -12.5
The Buffalo Bills are coming into this game with an impressive 2-0 record and a strong performance against the spread. With a home game at Highmark Stadium, where they have gone 7-0 ATS in recent regular-season games, the Bills look poised to continue their dominance.
The Miami Dolphins, on the other hand, have struggled with an 0-2 record and are finding it difficult on both offense and defense. Their road performance has been underwhelming, making it challenging to keep pace with a high-scoring team like the Bills.
In their head-to-head matchups, the Bills have consistently covered the spread against the Dolphins. The Dolphins’ inability to stop high-powered offenses further solidifies the expectation that the Bills will cover the -12.5 spread.
Given the current form and past encounters, the Bills are expected to win comfortably. A projected final score of Bills 38 – Dolphins 17 supports the spread pick of Bills -12.5.
- Bills vs Dolphins Prediction: Bills -12.5
- Bills vs Dolphins Score: Bills 38 – Dolphins 17
