MLB Game Prediction

Baltimore Orioles vs Tampa Bay Rays Prediction & Betting Tips for 9/23/2025

Want our best Baltimore Orioles vs Tampa Bay Rays prediction for 9/23/25? Get our MLB betting tip as the Rays travel to the Orioles on 9/23/25 at Oriole Park at Camden Yards, in Baltimore. Knup Sports has your free pick!

The Tampa Bay Rays head to Oriole Park at Camden Yards to take on the Baltimore Orioles in an AL East showdown. The Rays come into the game with a record of 76-80 and are ranked 4th in their division, having recently secured a win against the Boston Red Sox. Meanwhile, the Orioles hold a 73-83 record, sitting at 5th place in the division, and are currently on a two-game losing streak.

Weather conditions for the game forecast an overcast evening with a warm atmosphere and a light breeze. Both teams have been experiencing similar forms, each going 4-6 over their last ten games. With the Rays and Orioles close in the standings, this game may be pivotal for both teams as they aim to finish the season strong.

The Rays, managed by Kevin Cash, have shown mixed results on the road with a 35-40 record. On the other hand, the Orioles, under interim manager Tony Mansolino, have a slightly better home record at 37-41. Both teams will be looking to improve their division records, with the Rays at 19-27 and the Orioles at 20-26, as they meet on Tuesday night.

Orioles vs Rays At a Glance

  • Game Location: Oriole Park at Camden Yards, Baltimore, MD
  • Game Time: Tuesday, September 23, 2025 at 6:35 PM
  • Weather: Overcast Clouds with a warm temperature and light breeze
  • TV Broadcast: MASN
  • Team Records: Rays 76-80 (4th in AL East), Orioles 73-83 (5th in AL East)
  • Game Odds: Rays Moneyline -114, Orioles Moneyline -104

The Orioles Aim to Conclude Season Strong Against the Rays

Team Overview

The Baltimore Orioles, sitting at a record of 73-83, are wrapping up a challenging season. They are set to host the Tampa Bay Rays at Oriole Park at Camden Yards for a three-game series. With postseason hopes dashed, the Orioles are focused on ending their season on a high note.

Despite struggles, the Orioles have seen some bright spots, particularly in their home run tally, which ranks 11th in the league. However, their overall batting average of .237 places them 18th, indicating room for improvement offensively.

Key Players to Watch

Gunnar Henderson has been a consistent performer for the Orioles, boasting a .273 batting average with 16 home runs and 65 RBIs over 148 games. His contributions have been vital in keeping the Orioles competitive throughout the season.

Jackson Holliday, playing at second base, has also been a key player. He has hit 17 home runs and 55 RBIs, showing potential for future impact. As one of the younger members of the team, his development is crucial for the Orioles’ long-term plans.

Pitching Matchup

Dean Kremer will take the mound for the Orioles with a season record of 10-10 and an ERA of 4.39. Kremer aims to finish the season strong and provide stability against a potent Rays lineup.

His counterpart, Ryan Pepiot from the Rays, presents a tough challenge with an 11-11 record and an ERA of 3.77. Kremer’s performance will be pivotal in setting the tone for the series.

Betting Trends

  • SU Last 3 Games: 1-2 (33.3%)
  • SU in Home Games: 37-41 (47.4%)
  • Runline in Home Games: 36-42 (46.2%)
  • O/U All Games: 64-92 (41.0%)
  • O/U in Home Games: 34-44 (43.6%)

As the Orioles prepare for their final homestand, they’ll look to leverage home-field advantage and finish the season positively.

The Rays Look to Shine Against the Orioles in Baltimore

Baltimore Orioles Offensive Overview

The Orioles enter the matchup with a team batting average of .252, which ranks them 7th in the league. Their on-base percentage stands at .313, placing them in the middle of the pack at 15th.

Although their slugging percentage is ranked 13th with a value of .403, the Orioles have hit 177 home runs, also placing 13th in the league. However, they have struggled with doubles, ranking 21st with only 235.

Power and Patience

Despite the power shown with their home run total, the Orioles have demonstrated a lack of patience at the plate, ranking 26th in walks with just 451. This could impact their ability to generate runs against a savvy pitcher like Ryan Pepiot.

Their strikeout numbers are also concerning, as they rank 20th in the league with 1340 strikeouts. This could play into the hands of the Rays’ pitching staff, who excel at inducing strikeouts.

Base Running Strategy

The Orioles have been aggressive on the base paths, leading the league with 188 stolen bases. This could be a key factor against the Rays if they can get on base.

However, their base running might not be enough to compensate for their middling on-base skills, so the Orioles will need to capitalize on every opportunity they get against the Rays’ defense.

Orioles’ Pitching Insight

On the mound, Dean Kremer will start for the Orioles with a 4.39 ERA and a WHIP of 1.26. His record stands at 10-10, reflecting some inconsistency over the season.

Kremer’s ability to keep the Rays’ hitters in check will be crucial, especially given the power in the Rays’ lineup, led by Junior Caminero and Yandy Díaz.

Team Betting Trends

  • SU in Home Games: 35-40 (46.7%)
  • Runline in Home Games: 37-38 (49.3%)
  • O/U in Home Games: 33-42 (44.0%)

As the Orioles aim to finish their season strong, they will need to rely on their strengths while addressing their weaknesses against a competitive Rays team. The key for the Orioles will be to limit mistakes and capitalize on their speed and power.

Orioles vs Rays Prediction: Rays -114

The Tampa Bay Rays come into this game with a slight advantage over the Baltimore Orioles, based on their head-to-head record in 2025, where they have outperformed the Orioles with a 5-5 split, outscoring them slightly. Ryan Pepiot, the Rays’ starting pitcher, has a decent ERA of 3.77, which could give them an edge on the mound. With the moneyline odds at -114 for the Rays, it suggests a close matchup, but the Rays’ ability to perform slightly better in previous encounters makes them a favorable pick.

Yandy Diaz’s exceptional performance in September, hitting .435/.530/.623, showcases his strong form and provides an additional offensive boost for the Rays. While both teams have struggled in recent games, the Rays’ lineup, featuring key contributors like Diaz, may be better positioned to capitalize on the Orioles’ pitching, which has been inconsistent throughout the season. The addition of Adley Rutschman to the Orioles’ lineup might not be enough to offset their recent struggles.

Historically, the Rays have shown the ability to pull through in close contests against the Orioles, as evidenced by their marginally better average margin of victory. The Orioles’ pitching woes, with Dean Kremer’s ERA of 4.39, could be exploited by the Rays’ hitters, especially in a game where the weather conditions are not severe. Expect the Rays to capitalize on these factors and eke out a win.

The prediction for this matchup sees the Rays coming out on top with a final score projection of Rays 6 – Orioles 4, indicating a relatively high-scoring game given the overcast clouds potentially aiding the ball’s carry.

  • Orioles vs Rays Prediction: Rays -114
  • Orioles vs Rays Score: Rays 6 – Orioles 4
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