CFB Game Prediction

Alabama vs Vanderbilt Prediction & Betting Tips for CFB Week 6 on 10/4/2025

Want our best Alabama vs Vanderbilt prediction for 10/4/25? Get our College Football betting tip as the Vanderbilt travel to Alabama in Week 6 on 10/4/25 at Saban Field at Bryant-Denny Stadium, in Alabama. Knup Sports has your free CFB pick!

In Week 6 of the 2025 college football season, the Vanderbilt Commodores travel to Tuscaloosa to take on the Alabama Crimson Tide at Saban Field in Bryant-Denny Stadium. This afternoon game is set to kick off at 3:30 PM ET and will be broadcast on ABC. Both teams are members of the Southeastern Conference, adding an extra layer of competition to this encounter.

The Vanderbilt Commodores enter this game undefeated with a 5-0 record, including a 2-0 mark on the road. Currently ranked #16 in the AP Poll and #17 in the Coaches Poll, they have shown impressive form, most recently securing a 55-35 victory over Utah State. Their strong start this season includes a dominant 70-21 win against Georgia State and a comprehensive 31-7 triumph over South Carolina.

Alabama, ranked #10 in the AP Poll and #11 in the Coaches Poll, holds a 3-1 record with an unblemished 2-0 record at home. They are coming off a hard-fought 24-21 victory over Georgia in Athens. The Crimson Tide will look to leverage their home-field advantage as they aim to hand Vanderbilt its first loss of the season.

Alabama vs Vanderbilt At a Glance

  • Game Date & Time: Saturday, October 4, 2025 at 3:30 PM ET
  • Venue: Saban Field at Bryant-Denny Stadium in Tuscaloosa, AL
  • TV Channel: ABC
  • Alabama Odds: Moneyline -422, Spread -10.5 (-111)
  • Vanderbilt Odds: Moneyline +325, Spread +10.5 (-109)
  • Total Points Odds: Over/Under 56.5 (-110)

Alabama Crimson Tide Set for Showdown Against the Commodores

Vanderbilt Commodores: Offense Analysis

The Vanderbilt Commodores have been working to establish their offensive identity this season. Their passing game has seen gradual improvement, contributing to their ability to keep up with opponents. However, the ground game still faces challenges in gaining consistent yardage.

The Commodores’ offensive line remains a critical area to watch, as it will need to provide ample protection and create lanes for running backs. Consistency in execution could be key to any success they achieve in this game.

Vanderbilt Commodores: Defensive Overview

On the defensive side, the Commodores have shown a mix of promising talent and areas needing refinement. Their secondary is tasked with containing explosive plays, a challenge given Alabama’s passing efficiency.

The Commodores’ front seven will have the formidable task of containing Alabama’s rushing attack, despite its lower yardage rank. Pressure on the quarterback could disrupt Alabama’s offensive rhythm, making pass rush a crucial focus.

Key Players to Watch

Vanderbilt’s quarterback will be pivotal in directing the offense and avoiding costly turnovers against Alabama’s aggressive defense. His decision-making under pressure will be tested throughout the game.

Defensively, a standout linebacker for the Commodores is expected to play a significant role in both run support and pass coverage. His leadership on the field could be vital in rallying the defense against Alabama’s potent offense.

Team Betting Trends

  • SU – Last 10 Away Games → 3-7 (30%)
  • ATS – Last 5 Games as Underdog → 1-4 (20%)
  • O/U – Last 5 Games → 2-3 (40%)
  • ATS – After Loss → 1-4 (20%)

Game Outlook

The Commodores come into this game with the opportunity to prove their resilience against a strong Alabama team. To achieve success, Vanderbilt must execute a well-balanced attack and minimize turnovers.

As underdogs, Vanderbilt’s ability to keep the game competitive will rely heavily on defensive stops and capitalizing on any offensive opportunities. The game presents a challenging yet defining moment for the Commodores this season.

Vanderbilt Commodores Poised for Battle: A Deep Dive into Their 2025 Journey

Overview of Vanderbilt’s Offensive Strength

The Vanderbilt Commodores have been a force to reckon with in the 2025 regular season, ranking 2nd in points scored with an impressive 245 points. Their offensive prowess is further highlighted by their 1355 passing yards, placing them 16th, and a strong rushing game that has accumulated 1125 yards, landing them in 13th place.

Furthermore, their ability to consistently move the chains is evident as they have secured 131 first downs, earning them the 6th spot. This offensive efficiency is a testament to the strategic play-calling and the talent on their roster.

Defensive Highlights and Key Performers

On the defensive side, the Commodores have shown resilience, allowing 86 points against, positioning them at 54th. Their pass rush has been formidable with 14 sacks, ranking 7th, showcasing their ability to disrupt opposing offenses.

Vanderbilt’s secondary has also been effective, with 3 interceptions ranking them 4th, while their ability to capitalize on opponents’ mistakes is evident with 6 fumbles recovered, which is the best in the league.

Recent Dominant Performances

Vanderbilt’s recent games have been nothing short of dominant, including a commanding 55-35 victory over Utah State. Their offensive execution was on display, racking up 321 passing yards and 225 rushing yards.

In their matchup against Georgia State, the Commodores put up an astounding 70 points, supported by 349 passing yards and 287 rushing yards, illustrating their balanced attack.

Top Players to Watch

Quarterback Diego Pavia has been a standout, throwing for 1211 yards and 13 touchdowns, leading the league in both categories. His leadership on the field is crucial for Vanderbilt’s success.

Running back Sedrick Alexander has also made significant contributions, rushing for 243 yards and scoring 4 touchdowns. His versatility adds another dimension to their offense.

Team Betting Trends

  • ATS – Away Games: Last 6 Games (2024–2025) → 6-0 (100.0%)
  • SU – All Games: Last 5 Games (2025) → 5-0 (100.0%)
  • SU – As Favorite: Last 4 Games (2024–2025) → 4-0 (100.0%)
  • SU – After Win: Last 4 Games (2025) → 4-0 (100.0%)
  • O/U – As Favorite: Last 12 Games (2021–2025) → 10-2 (83.3%)

Alabama vs Vanderbilt Prediction: Alabama -10.5

In this SEC showdown, Alabama is a 10.5-point favorite at home against Vanderbilt. Given Alabama’s impressive home record of 29-1 in their last 30 home games and their ability to cover the spread in high-total games, the Crimson Tide are in a favorable position. Alabama’s strong offensive and defensive stats, coupled with their recent victory over Georgia, suggest they can handle a spread of this magnitude.

Vanderbilt, although undefeated this season, faces their toughest challenge yet on the road. While their offense has been prolific, ranking second in points scored, Alabama’s defense ranks 37th in points allowed, indicating they can potentially contain Vanderbilt’s offense. Alabama’s high-ranking interceptions and fumble recovery rates add another layer of difficulty for Vanderbilt’s offensive efforts.

The Crimson Tide’s recent ATS home game streak highlights their capability to not only win but also cover significant spreads. With a balanced attack, Alabama’s offense should capitalize on Vanderbilt’s defense, which ranks 54th in points against. Alabama’s consistent scoring and defensive strategies should secure them a comfortable win at home.

Projected final score: Alabama 38, Vanderbilt 24. Expect Alabama to extend their ATS home streak and cover the -10.5 spread. With their home-field advantage, consistent play, and strong betting trends, Alabama is poised to dominate this game.

  • Alabama vs Vanderbilt Prediction: Alabama -10.5
  • Alabama vs Vanderbilt Score: Alabama 38 – Vanderbilt 24
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