CFB Game Prediction

Louisville vs Boston College Prediction & Betting Tips for CFB Week 9 on 10/25/2025

Want our best Louisville vs Boston College prediction for 10/25/25? Get our College Football betting tip as the Boston College travel to Louisville in Week 9 on 10/25/25 at L&N Federal Credit Union Stadium, in Louisville. Knup Sports has your free CFB pick!

In Week 9 of the 2025 Regular Season, the Boston College Eagles will travel to face the Louisville Cardinals. The game will take place at the L&N Federal Credit Union Stadium in Louisville, KY, with a scheduled kickoff at 7:30 PM on October 25th. Fans can catch the action live on ACCN. The Boston College Eagles have faced significant challenges this season, holding a record of 1-6. They are still searching for their first road win, entering this game with a 0-3 road record and struggling within the Atlantic Coast Conference at 0-4. Their recent outing resulted in a 38-23 loss to the Connecticut Huskies. In contrast, the Louisville Cardinals have found success with a 5-1 overall record and a 3-1 record at home. Ranked #19 in the AP Poll, the Cardinals are coming off a narrow 24-21 victory against the Miami Hurricanes. Their strong performance in conference play has positioned them well in the Atlantic Coast standings.

Louisville vs Boston College At a Glance

  • Game Date & Time: Saturday, October 25, 2025, at 7:30 PM (Night Game)
  • Venue: L&N Federal Credit Union Stadium in Louisville, KY
  • Broadcast: Available on ACCN
  • Boston College Record: 1-6 this season, 0-3 on the road
  • Louisville Record: 5-1 this season, 3-1 at home
  • Odds: Louisville Moneyline -3389, Boston College Moneyline +1390

Louisville Cardinals Set to Host Boston College Eagles: An In-Depth Look

Offensive Insights

The Louisville Cardinals’ offense has seen a notable decline this season, with 204 points scored, placing them 45th overall. Their passing game has been somewhat effective, ranking 56th with 1693 yards. However, their rushing attack struggles significantly, ranking 117th with only 701 yards.

Comparing to last season, the Cardinals had a more potent offense, finishing 17th with 474 points. Their passing and rushing games were both stronger, ranking 27th and 31st, respectively.

Defensive Performance

Defensively, the Cardinals have been more consistent, allowing 126 points, ranking them 64th. They have demonstrated a strong ability to pressure quarterbacks, ranking 15th with 14 sacks this season.

Their secondary has been opportunistic, with 10 interceptions, placing them 11th in the nation. Additionally, they have recovered 3 fumbles, ranking 7th, showcasing their knack for creating turnovers.

Recent Game Recap

In their recent game against Miami, Louisville came away with a narrow 24-21 victory. The Cardinals managed to gain 21 first downs, with 248 passing yards and 122 rushing yards.

Key defensive plays included forcing 4 interceptions, which proved crucial in their win. Their ability to capitalize on turnovers was a deciding factor in the game.

Key Players

Quarterback Miller Moss has been a pivotal player for Louisville, throwing for 1606 yards, placing him 48th in the league. Moss has also thrown 9 touchdowns and 4 interceptions.

On the ground, Isaac Brown leads the rushing attack with 447 yards and 3 touchdowns. Wide receiver Chris Bell has been a standout, with 638 receiving yards and 6 touchdowns, ranking 8th in receiving yards.

Team Betting Trends

  • SU – As Favorite: 22-5 (81.5%) over the last 27 games
  • SU – Home Games: 19-4 (82.6%) over the last 23 games
  • SU – Totals ≥ 50: 21-5 (80.8%) over the last 26 games
  • SU – After Loss: 11-2 (84.6%) over the last 13 games
  • ATS – Home Games: 14-9 (60.9%) over the last 23 games
  • O/U – After Win: 11-4 (73.3%) over the last 15 games

Boston College Eagles: A Look Ahead as They Travel for Their Next Challenge

Offensive Analysis

The Boston College Eagles have shown a balanced approach in their passing game, ranking 28th nationally with 1,907 passing yards this season. Quarterback Dylan Lonergan is a pivotal part of this success, having thrown for 1,394 yards and 9 touchdowns in 6 games. Despite this, their ground game is struggling, ranking 116th with only 705 rushing yards.

Key receiver Lewis Bond has been a standout, securing 50 receptions and 505 yards, although he’s yet to score a touchdown. Reed Harris also contributes significantly with 337 receiving yards and 3 touchdowns. Turbo Richard is leading the rushing attack with 431 yards and 5 touchdowns, though the overall rushing stats are below average.

Defensive Struggles

Defensively, the Eagles have had a tough season, ranking 123rd by allowing 237 points against. The team shows promise with their ability to pressure quarterbacks, achieving 12 sacks to rank 17th. Their defensive backfield is opportunistic, securing 4 interceptions, placing them 5th nationally.

However, their struggles are evident in their recent games, giving up 48 points to Pittsburgh and 41 to Clemson. Injuries have further hampered their defense, with multiple players questionable for the upcoming game. The Eagles need to tighten up their defensive scheme to handle the aggressive offenses they will encounter.

Recent Performance

Boston College’s recent performances have been less than stellar, coming off a 38-23 loss to Connecticut. Prior to that, they suffered a 41-10 defeat to Clemson and a 48-7 loss at Pittsburgh. Their offense showed glimpses of potential, especially in the close 28-24 loss to California, where they managed 20 first downs.

Their defense, however, has been unable to contain opposing offenses, with significant points conceded in recent games. This pattern has been a recurring issue throughout the season, and it’s an area they must address to improve their record. Their next game against Louisville presents another challenging test.

Injury Impact

The Eagles’ injury list is extensive, with key players like Johnathan Montague Jr. out for the season with a torn ACL. Other players like Cameron Martinez and Jaylen Blackwell remain questionable, potentially impacting both their defensive and offensive capabilities. The extent of these injuries could influence their game strategy moving forward.

With multiple players uncertain for the upcoming game, depth will be tested, particularly in the defensive backfield and receiving corps. The coaching staff will need to make strategic adjustments to compensate for these absences.

Betting Trends

  • Overall, the Eagles have shown a strong tendency to go over the total in away games, with a 4-0-1 record in their last 5.
  • They are 10-2-1 in over/under for all games since 2024, reflecting a pattern of high-scoring games.
  • As an underdog, their over/under record stands at 15-5-2, indicating their potential to outperform expectations.
  • In games with totals of 50 or more, they are 7-2-1 in the over/under in the last 10 games.
  • Their ability to cover the spread as underdogs stands at 12-10 in the last 22 games.

Louisville vs Boston College Prediction: Over 55.5

Louisville has been strong offensively this season, averaging 204 points and ranking 45th in the nation. Boston College has struggled on defense, allowing 237 points and ranking 123rd. These figures suggest a high-scoring game.

In the previous meetings between these teams, high-scoring games have been common. The last two matchups have seen totals of 58 and 62 points, both surpassing the current total set at 55.5. Given these trends, the ‘over’ looks appealing.

Louisville’s home games have often gone over the total, with an 8-4 record in such situations over their last 12 games. This trend, coupled with Boston College’s defensive vulnerabilities, further supports an ‘over’ bet.

Considering both teams’ current form and historical performances, a projected final score of Louisville 42 – Boston College 24 seems likely, comfortably surpassing the total of 55.5.

  • Louisville vs Boston College Prediction: Over 55.5
  • Louisville vs Boston College Score: Louisville 42 – Boston College 24
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