CFB Game Prediction

Illinois vs Ohio State Prediction & Betting Tips for CFB Week 7 on 10/11/2025

Want our best Illinois vs Ohio State prediction for 10/11/25? Get our College Football betting tip as the Ohio State travel to Illinois in Week 7 on 10/11/25 at Memorial Stadium (Champaign, IL), in Illinois. Knup Sports has your free CFB pick!

As Week 7 of the 2025 College Football season approaches, the top-ranked Ohio State Buckeyes travel to Champaign, Illinois, to play the 17th-ranked Illinois Fighting Illini. Set to be held at Memorial Stadium on October 11, 2025, this Big Ten showdown kicks off at noon and will be aired on FOX. Both teams are coming into the game with strong records, adding to the anticipation surrounding this contest.

The Ohio State Buckeyes have dominated their schedule so far, maintaining a perfect 5-0 record, which includes a spotless conference record of 2-0. Their recent victory against Minnesota further solidified their status as the top team in the nation. On the other hand, the Illinois Fighting Illini hold a commendable 5-1 record, with their only setback occurring against Indiana, but they have remained undefeated at home, winning all three games played at Memorial Stadium.

In their last game, Illinois exhibited impressive offensive prowess with a 43-27 win over Purdue, racking up 390 passing yards. The Buckeyes, meanwhile, showcased their defensive strength against Minnesota, allowing only 94 passing yards in a dominant 42-3 victory. With both teams bringing different strengths to the field, the game promises to offer an intriguing contest between two Big Ten powerhouses.

Illinois vs Ohio State At a Glance

  • Game Day: Saturday, October 11, 2025 at 12:00 PM
  • Venue: Memorial Stadium in Champaign, IL
  • TV Coverage: FOX
  • Ohio State Record: 5-0, AP Rank #1
  • Illinois Record: 5-1, AP Rank #17
  • Game Odds: Ohio State favored by 14.5 points

Illinois Fighting Illini: Bracing for the Buckeyes

Quarterback Performance

Luke Altmyer has been a standout for Illinois this season, leading the team with 1,573 passing yards. His performance has been efficient, with 12 touchdowns and no interceptions through six games, placing him at the top in passing categories for Illinois.

Altmyer’s ability to avoid interceptions has been crucial in maintaining Illinois’s offensive momentum. His leadership will be pivotal against Ohio State, as the Buckeyes’ defense is known for pressuring opposing quarterbacks.

Running Game Analysis

The Illinois rushing attack is spearheaded by Kaden Feagin, who has accumulated 316 yards and five touchdowns. Complementing Feagin is Ca’Lil Valentine, contributing 323 yards and three touchdowns, making for a dynamic duo in the backfield.

Despite these efforts, the Illini’s rushing game ranks 74th nationally, indicating room for improvement. Establishing a strong ground game will be vital against Ohio State to control the clock and keep their offense off the field.

Receiving Corps Overview

Hank Beatty leads the receiving corps with 569 yards and two touchdowns, showcasing his deep-threat capability. Collin Dixon and Justin Bowick have also been reliable targets, each adding to Illinois’s offensive versatility.

Against a stout Buckeyes secondary, these receivers will need to capitalize on every opportunity. Stretching the field will be key in creating space for the running game and keeping Ohio State’s defense guessing.

Defensive Standouts

Illinois’s defense has been a mixed bag, allowing 144 points this season, ranking 88th. However, they’ve been proficient in creating turnovers, with eight fumble recoveries, ranking first nationally.

Their ability to pressure the quarterback is notable, with 14 sacks, placing them 10th in the nation. This pressure will need to be consistent to disrupt Ohio State’s offensive rhythm.

Betting Trends

  • SU – As Favorite: 9-0 in last 9 games
  • ATS – As Favorite: 6-0 in last 6 games
  • SU – Home Games: 9-1 in last 10 games
  • O/U – Away Games: 5-0 in last 5 games
  • SU – All Games: 8-1 in last 9 games
  • ATS – All Games: 8-1 in last 9 games

Injury Concerns

Illinois is dealing with significant injuries, with several key players questionable or out. Notably, Grant Smith and JJ Hirdes are out for the season, impacting the Illini’s depth.

These absences could affect both the offensive line’s protection and the defensive backfield’s effectiveness. The team’s resilience will be tested as they adjust to these challenges.

Game Outlook

Illinois enters this game as a 14.5-point underdog against Ohio State, with a total set at 50.5. Their recent form is promising, coming off a solid 43–27 victory over Purdue.

Continuing their winning ways will require a balanced attack and a disciplined defensive effort. Playing at home could provide the necessary boost to pull off an upset against the Buckeyes.

Ohio State Buckeyes Prepare for Illinois Challenge

Illinois Fighting Illini Offense Overview

Illinois will need to find a way to generate more first downs if they aim to keep up with Ohio State. The team has been inconsistent in moving the chains, something that could be problematic against the Buckeyes’ strong defense.

Quarterback play will be crucial for Illinois. They need to ensure efficient passing to avoid unnecessary turnovers that could shift momentum in Ohio State’s favor.

Defensive Strategies for Illinois

On defense, Illinois will have to contend with Ohio State’s passing game, which has been a significant factor in their victories. The Fighting Illini must focus on pressuring the quarterback to limit Ohio State’s aerial attack.

Containing Ohio State’s rushing game will also be essential. This will require disciplined play from the defensive line to prevent the Buckeyes from exploiting gaps.

Special Teams Outlook

Illinois’s special teams could play a pivotal role, especially if the game is closely contested. They will need effective kicking and punt return strategies to maximize field position advantages.

Attention to detail in special teams could potentially lead to pivotal moments, impacting the overall game flow against Ohio State.

Keys to Success for Illinois

Maintaining possession and minimizing turnovers will be critical for Illinois. They must execute disciplined football to limit Ohio State’s scoring opportunities.

Additionally, exploiting any weaknesses in Ohio State’s defense will be necessary for Illinois to have a chance at pulling off an upset.

Illinois Team Betting Trends

  • ATS – As Underdogs: Have covered the spread in 3 of their last 5 games.
  • O/U – Games with total ≤ 50: Under has hit in 4 of the last 6 games.
  • SU – All Games: Won 4 of the last 10 games when trailing at halftime.

Illinois vs Ohio State Prediction: Illinois +14.5

Ohio State comes into this game as the top-ranked team in the nation with an undefeated record. Their defense has been particularly strong, allowing only 25 points all season, which ranks fourth in the country. Despite this, covering a 14.5-point spread against a solid Illinois team on the road will be challenging.

Illinois has been impressive this season, boasting a 5-1 record and a perfect 3-0 at home. Their offense has been effective, ranking 11th in points scored, which suggests they can keep up with Ohio State. Additionally, Illinois has covered the spread in all four of their home games this season.

Given Illinois’ strong performance at home and their ability to score, taking them as 14.5-point underdogs appears to be a solid play. Ohio State’s defense might have a tough time containing Illinois’ offense, which could lead to a closer game than expected.

While Ohio State might secure the win, Illinois is likely to cover the spread. A projected final score of Ohio State 34, Illinois 24 supports this pick.

  • Illinois vs Ohio State Prediction: Illinois +14.5
  • Illinois vs Ohio State Score: Ohio State 34 – Illinois 24
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