NFL Game Prediction

Cardinals vs Titans Prediction & Betting Tips for NFL Week 5 on 10/5/2025

Want our best Cardinals vs Titans prediction for NFL week 5 on 10/5/25? Get our NFL betting tip as the Tennessee Titans travel to the Arizona Cardinals on 10/5/25 at State Farm Stadium, in Arizona. Knup Sports has your free pick!

The Tennessee Titans will travel to Glendale, AZ, to take on the Arizona Cardinals in Week 5 of the 2025 NFL season. The game is scheduled for Sunday, October 5, at 4:05 PM and will be held at State Farm Stadium, which features a retractable roof. Fans can tune in to CBS to catch the action live. The Titans, under head coach Brian Callahan, are still searching for their first win of the season with a record of 0-4-0. Their recent struggles include a 26-0 loss to the Houston Texans. The Titans’ offensive and defensive units will need to improve significantly to challenge the Cardinals. On the other hand, the Cardinals, led by head coach Jonathan Gannon, stand at 2-2-0 for the season. Although they lost their last game 23-20 against the Seattle Seahawks, they have shown potential with victories earlier in the season. With a balanced record at home, Arizona looks to bounce back on their turf.

Cardinals vs Titans At a Glance

  • Game Location: State Farm Stadium in Glendale, AZ USA — Retractable Roof
  • Broadcast: The game will be aired on CBS
  • Weather Considerations: Weather conditions are not specified, but wind may not impact play with the retractable roof
  • Cardinals Record: Arizona Cardinals hold a 2-2-0 record this season
  • Titans Record: Tennessee Titans are currently 0-4-0
  • Game Odds: Cardinals are favored with a -7.5 spread; Titans moneyline is +324

The Cardinals Eye a Victory in Upcoming Game

Offensive Performance

The Arizona Cardinals have shown a commendable offensive performance, scoring a total of 400 points, which places them 12th in the league. They have accumulated 3,639 passing yards, ranking 18th, while their rushing yards stand at 2,451, earning them the 7th spot. Their ability to secure first downs is notable, with 356 first downs, placing them 8th in the rankings.

On third down conversions, the Cardinals boast a 43% success rate, positioning them 8th in the league. Quarterback Kyler Murray has been a pivotal player with 742 passing yards, 6 touchdowns, and 3 interceptions. His performance has been instrumental in maintaining the Cardinals’ offensive momentum.

Defensive Strength

Defensively, the Cardinals have managed to hold their opponents to 379 points, ranking 14th. They have also excelled in applying pressure on the opposing quarterbacks, registering 41 sacks, which places them 8th in the league. The team has also shown a knack for recovering fumbles, with 8 recoveries, ranking 7th.

In terms of total opponent offensive yards, the Cardinals have allowed 5,823 yards, placing them 21st. However, their ability to intercept passes, with 9 interceptions, is commendable and ranks them 11th. Key defensive players like Calais Campbell and Jalen Thompson have been pivotal in their defensive efforts.

Recent Game Performances

In their most recent game against the Seattle Seahawks, the Cardinals narrowly lost 23-20. Kyler Murray threw for 200 yards, 2 touchdowns, and 2 interceptions, while Marvin Harrison Jr. contributed with 66 receiving yards and a touchdown.

Against the San Francisco 49ers, the Cardinals lost 16-15 in a closely contested game. Despite the loss, Trey McBride impressed with 43 receiving yards and a touchdown. The Cardinals’ defense held the 49ers to 73 rushing yards, showcasing their ability to stifle the ground game.

Team Betting Trends

  • SU – As Favorite (REG): Last 3 REG Games (2024–2025) → 3-0 (100.0%)
  • O/U – As Favorite (REG): Last 6 REG Games (2024–2025) → 5-1 (83.3%)
  • SU – Home Games (REG): Last 8 REG Games (2024–2025) → 6-2 (75.0%)
  • O/U – Home Games (REG): Last 5 REG Games (2024–2025) → 4-1 (80.0%)
  • ATS – Home Games (REG): Last 8 REG Games (2024–2025) → 5-3 (62.5%)
  • SU – After Win (REG): Last 8 REG Games (2024–2025) → 5-3 (62.5%)
  • SU – All Games (REG): Last 15 REG Games (2024–2025) → 8-7 (53.3%)
  • ATS – As Favorite (REG): Last 3 REG Games (2024–2025) → 2-1 (66.7%)
  • ATS – Away Games (REG): Last 3 REG Games (2024–2025) → 2-1 (66.7%)
  • ATS – After Win (REG): Last 3 REG Games (2025) → 2-1 (66.7%)
  • O/U – All Games (REG): Last 9 REG Games (2024–2025) → 5-4 (55.6%)
  • ATS – All Games (REG): Last 5 REG Games (2024–2025) → 3-2 (60.0%)
  • O/U – After Loss (REG): Last 5 REG Games (2024–2025) → 3-2 (60.0%)
  • O/U – After Win (REG): Last 4 REG Games (2024–2025) → 2-2 (50.0%)
  • SU – After Loss (REG): Last 4 REG Games (2024–2025) → 2-2 (50.0%)
  • ATS – After Loss (REG): Last 4 REG Games (2024–2025) → 2-2 (50.0%)
  • SU – As Underdog (REG): Last 7 REG Games (2024–2025) → 3-4 (42.9%)
  • ATS – As Underdog (REG): Last 7 REG Games (2024–2025) → 3-4 (42.9%)
  • SU – Away Games (REG): Last 3 REG Games (2024–2025) → 1-2 (33.3%)
  • O/U – Away Games (REG): Last 7 REG Games (2024–2025) → 2-5 (28.6%)

Titans Seek Redemption Against Cardinals: A Deep Dive into Tennessee’s 2025 Season

Offensive Struggles

The Tennessee Titans’ offense has had a challenging season, ranking 25th in scoring with 311 points. Passing efforts have been lackluster, landing them at 26th with 3317 yards, while their rushing game ranks 19th with 1855 yards. The Titans have managed only a 37.7% success rate on third downs, placing them 17th in the league.

In their most recent game against the Houston Texans, the Titans failed to score, showcasing a significant offensive issue. Key players like Cameron Ward and Tony Pollard were unable to find their rhythm, resulting in only 93 passing yards and 82 rushing yards. The Titans will need to make adjustments to find success against the Cardinals.

Defensive Highlights

Defensively, the Titans have faced their fair share of struggles, allowing 460 points, which ranks them 27th. However, they excel at limiting opponent offensive yards, standing second in the league with 5291 yards allowed. Their defense also ranks 9th in opponent passing interceptions and fumbles recovered, each with 11 and 6, respectively.

Despite their defensive efforts, the Titans have suffered consecutive losses, with a noticeable gap in first downs compared to opponents. Players like Jeffery Simmons have made significant impacts with sacks, yet the team needs to tighten up to avoid large score margins.

Key Player Contributions

Cameron Ward, as the starting quarterback, has thrown for 614 yards and 2 touchdowns this season. However, his performance has been inconsistent, and he has thrown 2 interceptions. Tony Pollard leads the rushing attack with 261 yards and 1 touchdown, ranking him 14th in the league.

On the receiving end, Elic Ayomanor has been a bright spot, recording 151 yards and 2 touchdowns. Chig Okonkwo has also contributed with 124 receiving yards, serving as a reliable target for Ward. For the Titans to compete, these key players must elevate their game against Arizona.

Injury Concerns

The Titans are dealing with several injuries that impact their depth. Key players like Treylon Burks and Will Levis are out for the season, affecting both their offensive and defensive capabilities. JC Latham and Bryce Oliver are questionable for Week 5, adding uncertainty to their lineup.

With Tyjae Spears and Anfernee Orji also sidelined, the Titans must rely on their backups to step up. The absence of these players could further hinder their efforts against the Cardinals, emphasizing the need for strategic adjustments.

Betting Trends

  • O/U – Home Games (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
  • O/U – As Underdog (REG): Last 11 REG Games (2024–2025) → 8-3 (72.7%)
  • O/U – All Games (REG): Last 11 REG Games (2024–2025) → 7-4 (63.6%)
  • O/U – Away Games (REG): Last 8 REG Games (2024–2025) → 5-3 (62.5%)
  • ATS – Away Games (REG): Last 3 REG Games (2024–2025) → 1-2 (33.3%)
  • SU – Away Games (REG): Last 6 REG Games (2024–2025) → 1-5 (16.7%)

Cardinals vs Titans Prediction: Over 41.5

The Arizona Cardinals have demonstrated a potent offensive capability, ranking 12th in scoring with 400 points in the 2024 season. This offensive strength, combined with their effective rushing attack, which ranked 7th with 2,451 yards, suggests they can put points on the board. At home, the Cardinals have hit the over in 4 of their last 5 games, indicating a trend towards high-scoring affairs in Glendale.

On the other hand, the Tennessee Titans’ defense has struggled, allowing 460 points in 2024, which ranked them 27th in the league. Their defense has had issues stopping offenses, particularly in the passing game, where they have been unable to limit yardage effectively. This defensive vulnerability could provide the Cardinals opportunities to score in bunches.

While the Titans have yet to win a game this season, their offense has shown flashes of potential with balanced passing and rushing attacks. Despite their 0-4 record, they may contribute to a high-scoring game by exploiting any lapses in the Cardinals’ 14th-ranked defense. With both teams showcasing potential for scoring, this matchup looks promising for the over.

The current game total is set at 41.5, which seems attainable given the offensive capabilities of the Cardinals and the defensive shortcomings of the Titans. A projected final score of Cardinals 30 – Titans 20 supports the belief that the teams will surpass the total, making the over a favorable choice.

  • Cardinals vs Titans Prediction: Over 41.5
  • Cardinals vs Titans Score: Cardinals 30 – Titans 20
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