CFB Game Prediction

Arizona vs Oklahoma State Prediction & Betting Tips for CFB Week 6 on 10/4/2025

Want our best Arizona vs Oklahoma State prediction for 10/4/25? Get our College Football betting tip as the Oklahoma State travel to Arizona in Week 6 on 10/4/25 at Arizona Stadium, in Arizona. Knup Sports has your free CFB pick!

In Week 6 of the 2025 college football season, the Oklahoma State Cowboys travel to Arizona Stadium in Tucson to meet the Arizona Wildcats. Scheduled for October 4th, this afternoon game kicks off at 3:00 PM and will be broadcast on TNT. The matchup showcases two Big 12 teams with contrasting starts to their seasons.

The Cowboys enter this game with a 1-3 record, struggling both at home and on the road, including a recent 45-27 defeat against Baylor. Their only win came against UT Martin in the season opener. They are looking to rebound against a Wildcats team that has been undefeated at home this season.

Arizona, meanwhile, sits at 3-1, having experienced just one defeat, which was away at Iowa State. The Wildcats have shown dominance at Arizona Stadium, winning all three games there this season. They are heavily favored in this matchup with a moneyline of -1309 and a spread of -20.5.

Arizona vs Oklahoma State At a Glance

  • Game Location: Arizona Stadium in Tucson, AZ
  • Game Date and Time: Saturday, October 4, 2025, at 3:00 PM
  • TV Channel: Broadcast on TNT
  • Oklahoma State Record: Currently 1-3 this season
  • Arizona Record: Holding a 3-1 record this season
  • Game Odds: Arizona favored with a moneyline of -1309; Oklahoma State at +775

Arizona Wildcats’ Strategy Unveiled: A Deep Dive into Their Upcoming Game

Team Overview

The Arizona Wildcats have had a mixed start to the 2025 season with a 2-2 record. Their offense ranks 54th in points scored with 125 points, relying heavily on a balanced attack of passing and rushing. Their passing game, led by quarterback Noah Fifita, ranks 73rd nationally with 998 yards.

On the defensive side, Arizona has allowed 65 points, positioning them 36th in the nation. The defense has shown strength in creating turnovers, with six interceptions ranking them 7th. Additionally, their pass rush has recorded 10 sacks, placing them 11th overall.

Key Players

Noah Fifita stands out as the leader of the Wildcats’ offense, having thrown for 965 yards and eight touchdowns this season. He has managed to maintain a solid presence under center, contributing significantly to the team’s offensive yardage.

Running back Ismail Mahdi has been pivotal in Arizona’s ground game, amassing 348 rushing yards over four games. His ability to break through defenses has been crucial for the Wildcats’ offensive balance.

Recent Performances

The Wildcats started the season strong with a dominant 48-3 victory over Weber State, showcasing their offensive capabilities with 406 passing yards. However, a recent 39-14 loss to Iowa State highlighted areas for improvement, particularly in preventing opponent scoring.

Arizona’s defense struggled against Iowa State, allowing 39 points and failing to contain the Cyclones’ passing attack. Despite these challenges, the Wildcats recorded two interceptions, demonstrating their potential to capitalize on opponent mistakes.

Upcoming Game Outlook

Arizona is set to play Oklahoma State at home, where they will look to improve their record. As 20.5-point favorites, the Wildcats are expected to leverage their home advantage and offensive prowess to secure a win.

With a focus on minimizing turnovers and maximizing their defensive playmaking, Arizona will aim to stifle Oklahoma State’s offense. The Wildcats’ ability to execute their game plan will be crucial in determining the outcome.

Team Betting Trends

  • SU – As Favorite: Last 16 Games (2022–2025) → 13-3 (81.2%)
  • O/U – Away Games: Last 4 Games (2024–2025) → 4-0 (100.0%)
  • ATS – As Favorite: Last 3 Games (2024–2025) → 3-0 (100.0%)
  • SU – Home Games: Last 3 Games (2025) → 3-0 (100.0%)
  • ATS – Home Games: Last 3 Games (2025) → 3-0 (100.0%)
  • SU – Totals ≥ 50: Last 3 Games (2025) → 3-0 (100.0%)

Oklahoma State Cowboys Seek Redemption on the Road

Offensive Struggles

The Oklahoma State Cowboys’ offense has had a rough start this season, managing only 69 points in their first four games, placing them 85th nationally. Their passing game has also been underwhelming, ranking 100th with 808 yards. Rushing hasn’t fared much better, with just 614 yards, sitting at 87th in the country.

One positive aspect has been their ability to earn first downs, with 75 so far, ranking them 51st. This indicates some potential for extending drives, but they need to convert these opportunities into points.

Defensive Challenges

On the defensive side, Oklahoma State has struggled significantly, allowing 140 points, which ranks them 97th nationally. While they have recorded five sacks, ranking 16th, their pass defense has been more effective with two interceptions, putting them 2nd in the nation.

However, their ability to recover fumbles, with only two so far, ranks them 5th. This turnover margin could play a crucial role in their upcoming games if they can capitalize on it.

Recent Game Performances

In recent games, the Cowboys have faced tough losses, including a 45-27 defeat against Baylor and a 19-12 loss to Tulsa. Their only win came against UT Martin in the season opener, a 27-7 victory.

Their most challenging game was against Oregon, where they suffered a 69-3 loss. This indicates the need for substantial improvement in both offensive and defensive strategies moving forward.

Key Players

Quarterback Zane Flores has led the charge with 649 passing yards, ranking him 106th nationally. Despite his efforts, he has yet to throw a touchdown, which the team desperately needs to change.

In the rushing department, Rodney Fields Jr. has accumulated 182 yards, ranking 204th. Wide receiver Gavin Freeman has been a standout with 118 receiving yards and one touchdown, providing a bright spot in the passing game.

Injury Concerns

Oklahoma State is dealing with several key injuries, including running back Freddie Brock IV and wide receiver Da’Wain Lofton, both listed as doubtful. The absence of these players could impact their offensive production.

Additionally, quarterback Hauss Hejny is questionable with a foot injury, which could limit their options at the QB position. These injuries add another layer of challenge for the Cowboys as they prepare for their next game.

Team Betting Trends

  • SU – As Favorite: 23-6 (79.3%) over the last 29 games.
  • O/U – As Underdog: 7-2 (77.8%) over the last 9 games.
  • O/U – Away Games: 8-4 (66.7%) over the last 12 games.
  • SU – Home Games: 21-9 (70.0%) over the last 30 games.
  • ATS – After Win: 18-12 (60.0%) over the last 30 games.

Arizona vs Oklahoma State Prediction: Over 55.5

Arizona Wildcats have shown a strong offensive performance with 125 points scored in four games this season, ranking them 54th in the nation. Their home record stands at 3-0, which indicates their capability to perform well in front of their home crowd.

On the other side, Oklahoma State Cowboys have struggled defensively, allowing 140 points in four games, ranking 97th. This defensive vulnerability could provide Arizona with ample opportunities to score.

Considering both teams’ current performance trends, the total points could easily surpass the set total of 55.5. The combination of Arizona’s home dominance and Oklahoma State’s defensive challenges suggests a high-scoring encounter.

A projected scoreline of Arizona 42 – Oklahoma State 21 supports the pick for the total points going over 55.5.

  • Arizona vs Oklahoma State Prediction: Over 55.5
  • Arizona vs Oklahoma State Score: Arizona 42 – Oklahoma State 21
To Top