MLB Game Prediction

Los Angeles Angels vs Houston Astros Prediction & Betting Tips for 9/28/2025

Want our best Los Angeles Angels vs Houston Astros prediction for 9/28/25? Get our MLB betting tip as the Astros travel to the Angels on 9/28/25 at Angel Stadium of Anaheim, in Los Angeles. Knup Sports has your free pick!

The Houston Astros, with an 86-75 record, are set to play against the Los Angeles Angels at Angel Stadium of Anaheim. As the Astros hold the second spot in the AL West division, their recent form has seen them win just four of their last ten games. Under the management of Joe Espada, they aim to capitalize on their recent victory over the Angels with a score of 6-1.

Conversely, the Los Angeles Angels find themselves at the bottom of the AL West division with a 72-89 record. Led by manager Ron Washington, the Angels have struggled, losing seven of their last ten games, including their most recent matchup against the Astros. Despite their current form, the Angels will look to rebound and close out their season on a positive note in front of their home crowd.

This afternoon game at Angel Stadium features a mild weather forecast with scattered clouds and a calm crosswind, which may influence play slightly. The Astros are favored with a moneyline of -125, while the Angels hold a moneyline of +105. Fans can tune in to watch the game on SCHN at 3:07 PM local time.

Angels vs Astros At a Glance

  • Away Team Record: Houston Astros stand at 86-75, ranked 2nd in AL West.
  • Home Team Record: Los Angeles Angels hold a record of 72-89, positioned 5th in AL West.
  • Stadium: The game will take place at Angel Stadium of Anaheim, an outdoor venue in Anaheim, CA.
  • Weather Forecast: Expect a mild day with calm crosswinds and scattered clouds.
  • TV Broadcast: Tune in to SCHN to watch the game.
  • Game Odds: Astros are favored with a moneyline of -125, while Angels are at +105.

Angels vs Astros: An In-Depth Look at the Los Angeles Angels’ Recent Performance

Team Overview

The Los Angeles Angels have faced a challenging season, finishing with a record of 72-89. Despite the struggles, the team has displayed moments of promise, particularly with standout performances from individual players like Jo Adell and Mike Trout. The Angels’ offense has been marked by power, ranking 4th in the league with 225 home runs.

However, their overall hitting metrics leave room for improvement, with a batting average of .225, ranking 18th. The team’s on-base percentage stands at .297, placing them 22nd in the league, indicating issues with consistently getting runners on base.

Key Players

Jo Adell has been a bright spot for the Angels, driving in 98 RBIs with one game left to potentially reach the 100-RBI milestone. His ability to contribute key hits has been crucial for the team’s offensive output. Mike Trout, despite battling injuries, continues to be a significant contributor with 25 home runs and 63 RBIs.

Taylor Ward and Nolan Schanuel have also been important to the lineup. Ward’s 36 home runs and 103 RBIs highlight his power-hitting ability, while Schanuel provides a steady presence with a .264 batting average.

Pitching Challenges

The Angels’ pitching staff has struggled throughout the season, with a team ERA of 4.88, which ranks 28th in the league. Opponents have managed a batting average of .259 against Angels’ pitchers, showing that the staff has had trouble keeping batters in check.

Sam Aldegheri is set to start against the Astros, bringing an ERA of 8.00 into the game. His performance will be crucial in determining whether the Angels can finish the season on a positive note.

Injury Report

The Angels have been plagued by injuries, with several key players on the injured list. Notable absences include Andrew Chafin, Jorge Soler, and Anthony Rendon, which have impacted both their pitching depth and offensive lineup.

Yusei Kikuchi is listed as day-to-day with a forearm injury, adding to the pitching staff’s challenges. These injuries have tested the team’s depth and ability to adapt throughout the season.

Betting Trends

  • SU in Away Games: 33-48 (40.7%)
  • Runline as Underdog: 72-50 (59.0%)
  • O/U as Underdog: 64-58 (52.5%)
  • SU After a Loss: 42-46 (47.7%)

Houston Astros: A Strategic Overview of Their Upcoming Game

Team Performance Overview

The Astros have shown solid team performance, ranking 8th in batting average at .250 for the 2025 season. However, their on-base percentage and slugging percentage rank 14th, both of which highlight areas for improvement. Defensively, their pitching has been stronger, with a 3.88 ERA placing them 12th in the league and a batting average against of .232, ranking 4th.

A key statistic for the Astros is their strikeout capability, leading the league with 1,495 strikeouts. Despite a strong start, their consistency has wavered, evidenced by their 17 blown saves, the second-highest in the league. Their quality starts, however, remain impressive at 70, ranking 3rd overall.

Key Players to Watch

Christian Walker continues to be a powerhouse for the Astros, with 27 home runs and 88 RBIs, both leading the team. Despite a .238 batting average, his power-hitting remains crucial. Jeremy Peña is another standout with a .304 batting average, 17 home runs, and 62 RBIs, contributing significantly to the team’s offensive efforts.

Yainer Diaz, with 19 home runs and a .255 average, provides depth to the batting lineup. His performance alongside Isaac Paredes, who boasts 20 home runs and a .254 average, adds a strong middle order presence. Carlos Correa’s .276 average and consistent hitting also bolster the Astros’ offense.

Challenges and Opportunities

The Astros’ ability to win close games is notable, with a 27-17 record in 1-run games, highlighting their resilience in tight situations. However, their inability to maintain momentum after wins, with a 40-45 record, poses a challenge. Their 45-30 record after losses indicates an ability to bounce back, a valuable trait for any competitive team.

Injuries have been a concern, with key players like Yordan Alvarez and Josh Hader sidelined, impacting their lineup and bullpen depth. These absences offer opportunities for emerging talents to step up and prove their worth. The return of players like Alvarez could provide a significant boost.

Betting Trends

  • Straight Up Last 3 Games: 2-1 (66.7%)
  • Runline as Underdog: 39-20 (66.1%)
  • Over/Under Last 10 Games: 4-6 (40.0%)
  • SU After a Loss: 45-30 (60.0%)
  • Runline After a Loss: 41-34 (54.7%)

Upcoming Game Considerations

Lance McCullers Jr. takes the mound for the Astros, carrying a 6.71 ERA and a challenging WHIP of 1.85. His performance will be crucial in managing the Angels’ lineup. With a win-loss record of 2-5, McCullers has the opportunity to turn his season around with a strong outing.

Offensively, the Astros will rely on their power hitters to exploit the Angels’ pitching vulnerabilities. Sam Aldegheri of the Angels, with an 8.00 ERA, presents a potential target for the Astros’ bats. The game strategy will likely focus on aggressive batting to capitalize on this matchup.

Angels vs Astros Prediction: Over 9.5

The upcoming game between the Astros and the Angels features two pitchers with high ERAs, which could lead to an offensive showdown. Lance McCullers Jr. has struggled this season, posting a 6.71 ERA, while Sam Aldegheri’s ERA is even higher at 8.00. With both teams having potential to exploit these pitching weaknesses, a high-scoring game is likely.

The head-to-head history between these teams this season shows a tendency towards lower-scoring games, but the dynamic changes with such vulnerable starters on the mound. The Astros and Angels have shown they can put up runs, especially against subpar pitching. Given the Astros’ rank in home runs and the Angels’ ability to score in bunches, this matchup leans towards more scoring.

Betting trends also suggest an inclination towards the total going over, despite a recent pattern of unders in this matchup. The consensus sportsbook has set the total at 9.5, and with both teams eliminated from postseason contention, they might play more freely, potentially leading to a higher-scoring affair. This creates an ideal scenario for taking the over.

Projected final score for this game is Astros 8 – Angels 6, suggesting a total that comfortably exceeds the over/under line. Expect offensive fireworks from both lineups as they capitalize on the pitching struggles.

  • Angels vs Astros Prediction: Over 9.5
  • Angels vs Astros Score: Astros 8 – Angels 6
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