MLB Game Prediction

Milwaukee Brewers vs Cincinnati Reds Prediction & Betting Tips for 9/26/2025

Want our best Milwaukee Brewers vs Cincinnati Reds prediction for 9/26/25? Get our MLB betting tip as the Reds travel to the Brewers on 9/26/25 at American Family Field, in Milwaukee. Knup Sports has your free pick!

The Cincinnati Reds will take on the Milwaukee Brewers in a night game at American Family Field in Milwaukee. The Reds, managed by Terry Francona, come into this game with a record of 81-78 and have won 7 of their last 10 games. They are currently ranked 3rd in the NL Central division.

On the other side, the Brewers, under the guidance of manager Pat Murphy, boast a record of 96-63, holding the top spot in the NL Central. They have had a mixed run in their last 10 games, going 5-5. With a solid home record of 51-27, the Brewers will look to continue their success at home.

As the game unfolds on September 26, 2025, fans can catch the action on FDSWI. The weather forecast indicates a mild day with a light breeze, though the retractable roof at American Family Field means conditions should remain optimal for play. The odds are in favor of the Brewers with a moneyline of -164, while the Reds sit at +139.

Brewers vs Reds At a Glance

  • Teams and Records: Cincinnati Reds (81-78) vs. Milwaukee Brewers (96-63)
  • Location: American Family Field, Milwaukee, WI
  • Game Time: Friday, September 26, 2025, at 8:10 PM
  • TV Broadcast: FDSWI
  • Weather: Few clouds with a mild breeze, retractable roof may negate wind effects
  • Betting Odds: Brewers favored with a moneyline of -164

Brewers Aim for Victory Against the Reds in Crucial Game

Team Overview

The Cincinnati Reds are entering this game with a strong intent to secure a postseason berth. Currently fighting for a wild card spot, every game is critical for them as they face a formidable opponent in the Milwaukee Brewers. The Reds have shown resilience in their recent performances, making this matchup one to watch.

In terms of pitching, the Reds will rely on Zack Littell to deliver a solid performance. Littell has maintained a 3.86 ERA this season, showcasing his ability to control games effectively. His career performance against the Brewers shows promise, with a 1.71 ERA in previous matchups.

Key Players to Watch

Joey Votto remains a central figure for the Reds, providing experience and a steady bat in the lineup. His veteran presence is crucial in high-pressure situations, especially as the team pushes for a playoff position. Votto’s performance will be pivotal in determining the Reds’ success.

Jonathan India, the Reds’ second baseman, has been a standout performer throughout the season. His contributions at the plate and on the field have been instrumental in keeping the Reds competitive. India’s ability to get on base and create scoring opportunities is vital for the Reds’ offensive strategy.

Pitching Strategy

With Zack Littell on the mound, the Reds will look to capitalize on his command and ability to limit runs. Littell’s experience against the Brewers could be a deciding factor in this crucial game. His performance will need to be sharp to outduel Milwaukee’s Quinn Priester.

The Reds’ bullpen will also play a significant role in maintaining any lead they may secure. Having a reliable bullpen is crucial in tight games, and the Reds will need their relievers to step up against the Brewers’ potent lineup.

Betting Trends

  • SU in Away Games: 45-36 (55.6%)
  • Runline as Underdog: 45-19 (70.3%)
  • O/U as Underdog: 26-38 (40.6%)

The Reds have a positive runline performance as underdogs, indicating they often keep games close or win outright when not favored. This could influence betting decisions, especially with Littell’s previous success against the Brewers.

As the Reds face the Brewers, both teams have much at stake, making this a pivotal matchup. The Reds need to bring their best to challenge Milwaukee, with Littell’s performance and their offensive consistency being key factors in determining the outcome.

The Reds Are Ready: Cincinnati Faces the Milwaukee Brewers

Brewers’ Offensive Overview

The Milwaukee Brewers are coming into this series with a solid offensive lineup, focusing on maintaining their strong performance at home. Their lineup is balanced with power hitters and consistent contact players who have contributed to their success this season.

Milwaukee’s offense is well-rounded, with key players contributing significantly in home runs and RBIs. Their ability to get on base and capitalize on scoring opportunities makes them a formidable opponent.

Key Players to Watch

Leading the charge for the Brewers is their star outfielder, who has consistently delivered in clutch situations. His batting average and on-base percentage rank among the top in the league, making him a critical player in the lineup.

Their infield is equally strong, with several players capable of changing the game with a single swing. Power and agility in the infield have been instrumental in turning potential base hits into outs, adding an extra layer of defense.

Pitching Strengths

Quinn Priester is set to take the mound for the Brewers, bringing a remarkable 13-2 record and a 3.25 ERA. His precision and ability to control the game have been key factors in Milwaukee’s pitching success this season.

The Brewers’ bullpen has also been a force, effectively closing out games and maintaining leads. Their depth in relief pitching ensures that they can handle high-pressure situations effectively.

Team Betting Trends

  • SU All Games: 81-78 (50.9%)
  • Runline as Underdog: 53-34 (60.9%)
  • O/U All Games: 58-101 (36.5%)
  • SU in Away Games: 36-42 (46.2%)
  • O/U in Away Games: 32-46 (41.0%)

Brewers vs Reds Prediction: Brewers -164

The Brewers have been a dominant force at home this season with a record of 51-27, showcasing their ability to perform well in front of their home crowd. Quinn Priester, their starting pitcher, has been consistent with a strong 3.25 ERA and a solid record of 13-2, which should give Milwaukee a significant edge against the Reds. Cincinnati’s Zack Littell, while serviceable, has a higher ERA of 3.86 and faces a tougher challenge against the Brewers’ well-rounded offense.

Milwaukee’s offense has been impressive, ranking 11th in batting average and 3rd in runs scored. This depth and consistency should challenge the Reds’ pitching staff significantly. Additionally, the Brewers have outscored the Reds by an average of 1.3 runs over their past matchups, further highlighting their superior offensive capability.

While the Reds are fighting for a wild card spot, the Brewers have the additional motivation of setting a new franchise record for wins and securing home-field advantage throughout the playoffs. The Brewers’ recent form at home and Priester’s track record suggest they have the upper hand in this critical game.

Given the Brewers’ home dominance, strong starting pitching, and superior offensive metrics, they are well-positioned to claim victory in this game. I predict the Brewers will secure a win with a final score of Brewers 5 – Reds 3.

  • Brewers vs Reds Prediction: Brewers -164
  • Brewers vs Reds Score: Brewers 5 – Reds 3
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