MLB Game Prediction

New York Yankees vs Baltimore Orioles Prediction & Betting Tips for 9/26/2025

Want our best New York Yankees vs Baltimore Orioles prediction for 9/26/25? Get our MLB betting tip as the Orioles travel to the Yankees on 9/26/25 at Yankee Stadium, in New York. Knup Sports has your free pick!

The Baltimore Orioles will take on the New York Yankees at Yankee Stadium on Friday, September 26, 2025, at 7:05 PM. The Orioles, led by interim manager Tony Mansolino, hold a record of 75-84 and are currently ranked fifth in the AL East. They are coming off a narrow 6-5 win against the Tampa Bay Rays, showing some positive momentum with a 6-4 record in their last ten games.

In contrast, the Yankees are dominating the AL East with a 91-68 record and are on a strong five-game winning streak. With Aaron Boone at the helm, the Yankees have been impressive, posting an 8-2 record in their last ten games. Their recent 5-3 win over the Chicago White Sox has solidified their position as division leaders.

The game will be broadcast on MLBN, and the weather is expected to be warm with a light breeze under broken clouds. The Yankees are favored in this matchup with a moneyline of -150, while the Orioles stand at +126. This game offers an exciting night of baseball as the Orioles aim to challenge the Yankees on their home turf.

Yankees vs Orioles At a Glance

  • Game Date: Friday, September 26, 2025, at 7:05 PM (Night Game)
  • Stadium: Yankee Stadium in New York, NY — Outdoor Field
  • Weather Forecast: Warm day with a light breeze, conditions described as ‘Broken Clouds’
  • TV Channel: MLBN
  • Yankees Record: 91-68, Division Rank: 1, Streak: W5
  • Game Odds: Yankees Moneyline: -150, Orioles Moneyline: +126

Yankees Prepare to Host Orioles: A Key Showdown at Yankee Stadium

Baltimore Orioles Offensive Overview

The Baltimore Orioles have been a consistent force at the plate, with their lineup showing depth and power throughout the 2025 season. While their overall batting average may not lead the league, they have relied on strategic hitting and timely power to drive in runs.

Key contributors in the Orioles lineup have been pivotal in creating scoring opportunities. Their ability to capitalize on these chances will be essential as they face a Yankees pitching staff known for its ability to control games.

Impact Players to Watch

Trey Mancini has been an integral part of the Orioles’ offensive push this season. With his ability to hit for both average and power, Mancini’s presence in the lineup often dictates the team’s success at the plate.

Adley Rutschman, the promising young catcher, has continued to impress with his development and impact both offensively and defensively. Rutschman’s contributions have been vital, and his performance against the Yankees’ pitching will be closely monitored.

Orioles Pitching Staff

Baltimore’s pitching staff has been anchored by standout performances from their starters, with Trevor Rogers leading the charge. Rogers boasts an impressive ERA of 1.35, making him a challenging opponent for any lineup.

In addition to Rogers, the bullpen has provided stability in late-game situations. Their effectiveness in preserving leads will be crucial against a potent Yankees lineup that thrives in clutch moments.

Team Betting Trends

  • SU in Away Games: 44-37 (54.3%)
  • SU vs Division Opponents: 33-34 (49.3%)
  • Runline in Away Games: 35-46 (43.2%)
  • O/U in Away Games: 40-41 (49.4%)

Orioles Prepare for a Showdown Against the Yankees

Team Overview

The Orioles are heading into their final series of the season against the New York Yankees, aiming to finish strong. Currently sitting at 75-84, the Orioles have had a season filled with ups and downs. They are looking to secure a few more wins to potentially overtake the Tampa Bay Rays in the AL East standings.

With a team batting average of .236, the Orioles rank 15th in the league, showing they have room for improvement offensively. Their slugging percentage of .395 ranks 17th, suggesting that while they have power, consistency is needed.

Key Players to Watch

Gunnar Henderson stands out as a key player for the Orioles, playing in 151 games this season with a batting average of .274. His contribution of 16 home runs and 67 RBIs showcases his importance in the lineup.

Ryan Mountcastle has also been a significant contributor, with a batting average of .253 and seven home runs. His future with the team is uncertain, making these final games potentially pivotal for him.

Pitching Dynamics

Trevor Rogers will be taking the mound for the Orioles, bringing an impressive 1.35 ERA and a 9-2 record into the game. His performance will be crucial in setting the tone against the Yankees.

On the flip side, the Orioles’ pitching staff has struggled at times, with an overall ERA of 4.59, ranking 24th in the league. Limiting home runs will be a focus as they have given up 209 this season, placing them 26th in that category.

Team Betting Trends

  • SU Last 3 Games: 2-1 (66.7%)
  • SU Last 10 Games: 6-4 (60.0%)
  • Runline as Underdog: 51-41 (55.4%)
  • O/U All Games: 65-94 (40.9%)
  • SU in Away Games: 36-42 (46.2%)

Recent Performances

In their recent home finale against the Tampa Bay Rays, Dylan Beavers hit a walk-off home run, securing a 6-5 victory. This victory was a bright spot in a challenging season.

Despite their struggles, the Orioles have shown moments of resilience, as seen in their recent win against the Rays, indicating their potential to compete against strong teams like the Yankees.

Yankees vs Orioles Prediction: Yankees -150

The New York Yankees have been in exceptional form, winning their last five games and achieving an 8-2 record over their last ten games. With a strong home record of 47-31 and an impressive batting lineup that leads the league in home runs and slugging percentage, they look poised for another victory.

Despite the Orioles’ recent win and Trevor Rogers’ stellar pitching statistics, the Yankees’ lineup, featuring power hitters like Giancarlo Stanton, provides a significant challenge. The Yankees’ Will Warren, while less consistent, benefits from the robust offensive support of his team.

Yankee Stadium’s atmosphere and the Yankees’ strong track record in night games (59-46) offer additional advantages. The combination of their offensive prowess and current momentum makes them the favorites at -150 odds.

Considering the Yankees’ superior hitting and the Orioles’ challenges on the road, the projected final score leans in favor of the Yankees, 5-3.

  • Yankees vs Orioles Prediction: Yankees -150
  • Yankees vs Orioles Score: Yankees 5 – Orioles 3
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