Cardinals vs Seahawks At a Glance
- Game Location: State Farm Stadium in Glendale, AZ with a retractable roof.
- Kickoff Time: Thursday, September 25, 2025, at 8:15 PM.
- TV Broadcast: Available on AMZN.
- Current Weather: Very hot with a light breeze, clear skies expected.
- Team Records: Both Seattle Seahawks and Arizona Cardinals have a 2-1-0 record this season.
- Betting Lines: Seahawks are favored at -119 on the moneyline; Cardinals are at +100.
Arizona Cardinals Prepare for Challenging Week 4 Against Seahawks
Offensive Strengths
The Arizona Cardinals have shown a solid offensive performance in the 2024 season, ranking 12th in overall scoring with 400 points. Their rushing attack has been particularly effective, racking up 2,451 yards, placing them 7th in the league. Additionally, their ability to convert third downs, with a percentage ranked 8th, has helped sustain drives and keep the pressure on opposing defenses.
Kyler Murray has been a key contributor, leading the team with 542 passing yards and 4 touchdowns over the first three games of the 2025 season. His versatility as a dual-threat quarterback has made the Cardinals’ offense unpredictable and difficult to defend. Despite some challenges in the passing game, Murray’s connection with tight end Trey McBride has provided stability.
Defensive Capabilities
The Cardinals’ defense has been effective in pressuring opposing quarterbacks, ranking 8th in sacks with 41 in the 2024 season. Their ability to recover fumbles, with 8 recoveries ranking them 7th, has been crucial in creating turnovers. However, the defense has struggled at times, allowing 5,823 opponent yards, which ranks them 21st in the league.
Safety Jalen Thompson has been a standout player on defense, contributing significantly with tackles and coverage plays. The Cardinals will need to tighten up their pass defense to limit big plays, especially against the Seahawks’ potent aerial attack. The absence of key defensive players due to injuries could pose a challenge in maintaining their defensive effectiveness.
Recent Game Performances
In their recent game against the San Francisco 49ers, the Cardinals narrowly lost 16-15, despite outgaining the 49ers in rushing yards. Their defense limited the 49ers’ rushing attack to just 73 yards, showcasing their ability to control the ground game. Unfortunately, the Cardinals’ passing game struggled, managing only 154 yards through the air.
Earlier in the season, the Cardinals secured a 27-22 victory over the Carolina Panthers. Kyler Murray’s performance, with 220 passing yards and 1 touchdown, played a pivotal role in the win. The team’s defensive line was instrumental, with Calais Campbell recording two sacks, highlighting their pass-rushing prowess.
Injury Concerns
The Cardinals are dealing with several injury concerns that could impact their performance in the upcoming game against the Seahawks. James Conner’s absence due to foot surgery is a significant blow to their rushing attack. Other key players, such as Kelvin Beachum and Zay Jones, are questionable, affecting the team’s depth and versatility.
On the defensive side, the loss of Justin Jones and Bilal Nichols weakens the interior line, potentially making it challenging to stop the Seahawks’ run game. The secondary is also affected, with several cornerbacks dealing with injuries, which could expose vulnerabilities against Seattle’s passing attack.
Team Betting Trends
- O/U – Home Games (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
- SU – As Favorite (REG): Last 3 REG Games (2024–2025) → 3-0 (100.0%)
- SU – Home Games (REG): Last 3 REG Games (2024–2025) → 3-0 (100.0%)
- O/U – As Favorite (REG): Last 6 REG Games (2024–2025) → 5-1 (83.3%)
- ATS – Home Games (REG): Last 7 REG Games (2024–2025) → 5-2 (71.4%)
- SU – All Games (REG): Last 4 REG Games (2024–2025) → 3-1 (75.0%)
Seattle Seahawks Seek to Soar in Arizona
Arizona Cardinals: Offensive Overview
The Arizona Cardinals will be relying on their quarterback to guide an offense that has shown potential in previous games. Their ability to create passing opportunities will be critical in challenging the Seahawks’ defense, which has been effective against the pass. Establishing a balanced attack, including a productive running game, will be key to keeping the Seahawks’ defense guessing.
The Cardinals have demonstrated moments of offensive flair, but consistency remains a challenge. They will need to improve their third-down conversion rate to sustain drives and keep the Seattle offense off the field.
Cardinals Defense: Aiming for Sturdiness
The Cardinals’ defense faces the tough task of containing a Seattle offense that ranks 8th in passing yards. Their defensive line must apply pressure and disrupt the rhythm of Seattle’s quarterback, Sam Darnold, who has shown efficiency in recent outings.
With the Seahawks’ running game ranked 27th, the Cardinals will aim to limit ground gains and focus on forcing passing downs. Interceptions and forced turnovers could prove pivotal in shifting the game’s momentum in their favor.
Key Players to Watch
Arizona’s quarterback will be under the spotlight as he looks to exploit Seattle’s defensive vulnerabilities. The performance of their lead wide receiver could be a game-changer if he can create separation and capitalize on deep balls.
Defensively, the Cardinals’ secondary will need to be on high alert against Seattle’s receiving threats like Jaxon Smith-Njigba and Cooper Kupp. The battle between Arizona’s cornerbacks and Seattle’s receivers could be decisive.
Game Strategy and Adjustments
The Cardinals’ coaching staff must emphasize minimizing errors and penalties, which can be detrimental against a disciplined Seattle team. Offensive adjustments, such as quick passes and screen plays, may help counteract Seattle’s pass rush.
On defense, strategic blitzes and varied coverage schemes could disrupt Seattle’s offensive timing. The Cardinals will need to adjust swiftly to Seattle’s in-game strategies to maintain competitiveness.
Team Betting Trends
- SU – Home Games (REG): Last 5 REG Games (2024–2025) → 3-2 (60.0%)
- ATS – Home Games (REG): Last 5 REG Games (2024–2025) → 3-2 (60.0%)
- O/U – Home Games (REG): Last 5 REG Games (2024–2025) → 2-3 (40.0%)
- SU – After Win (REG): Last 4 REG Games (2024–2025) → 2-2 (50.0%)
- ATS – After Win (REG): Last 4 REG Games (2024–2025) → 2-2 (50.0%)
- O/U – After Win (REG): Last 4 REG Games (2024–2025) → 3-1 (75.0%)
Cardinals vs Seahawks Prediction: Seahawks -1.5
The Seattle Seahawks have a proven track record against the Arizona Cardinals, especially in recent meetings at State Farm Stadium, where they have consistently managed to cover the spread. Their record this season stands at 2-1, with a notable away victory, indicating their capability on the road. With a spread of -1.5, the Seahawks are slightly favored, and given their historical performance, they seem well-positioned to cover this spread.
On the other hand, the Cardinals also hold a 2-1 record this season and have shown strong performances at home with a 1-0 home record. However, their history against the Seahawks at home is not favorable, as evidenced by previous head-to-head results. The Seahawks’ defensive strength, ranked 11th in opponent score last season, could be the key factor in limiting the Cardinals’ offensive efforts.
The Seahawks’ offense, ranked 8th in passing yards last season, could be a crucial factor in exploiting the Cardinals’ defense. Arizona, ranked 21st in opponent offensive yards allowed last season, might struggle to contain the Seahawks’ passing game. This matchup suggests that the Seahawks can capitalize on their offensive edge, making them the preferred choice against the spread.
Projected final score supports a Seahawks victory, given their past success and current form. A score of Seahawks 27 – Cardinals 23 fits the narrative of a close contest but ultimately favors Seattle to cover the -1.5 spread.
- Cardinals vs Seahawks Prediction: Seahawks -1.5
- Cardinals vs Seahawks Score: Seahawks 27 – Cardinals 23
