In Week 5 of the 2025 college football season, the LSU Tigers will travel to Vaught-Hemingway Stadium to play against the Ole Miss Rebels. The game is scheduled for September 27, 2025, at 3:30 PM ET and will be broadcast on ABC. Both teams enter the contest with perfect 4-0 records, adding to the anticipation surrounding this Southeastern Conference showdown. The LSU Tigers, ranked fourth in both the AP and Coaches polls, have been dominant this season. Their recent victories include a commanding 56-10 win against the Southeastern Louisiana Lions and a 20-10 win over the Florida Gators. This game marks their second road game of the season, as they previously defeated Clemson 17-10 on the road. On the other side, the Ole Miss Rebels have showcased impressive offensive performances, including a 63-7 victory over Georgia State and a 45-10 win against Tulane. Currently ranked 13th in the AP poll and 11th in the Coaches poll, the Rebels have a strong home record this season. With both teams undefeated and playing at a high level, this game is set to be a pivotal SEC matchup.
Ole Miss vs LSU At a Glance
- Game Venue: Vaught-Hemingway Stadium in Oxford, MS
- Game Date & Time: Saturday, September 27, 2025 at 3:30 PM ET
- TV Broadcast: ABC
- LSU’s Current Record: 4-0
- Ole Miss’ Current Record: 4-0
- Game Odds: LSU Moneyline -101, Ole Miss Moneyline -119, Total Points 54.5
Ole Miss Rebels’ Quest for Victory Continues
Dynamic Offense
The Ole Miss Rebels’ offense has been a powerhouse this season, scoring 179 points and securing the 10th spot nationally. Their passing game is particularly strong, with 1,299 passing yards, ranking them 9th. This high-powered offense keeps opponents on their toes, with a balanced approach of both passing and rushing plays.
In their last game against Tulane, Ole Miss dominated with 307 passing yards and 241 rushing yards, leading to a 45-10 victory. Quarterback Trinidad Chambliss is a key contributor, with 719 passing yards across four games.
Defensive Strengths
Ole Miss’s defense has been robust, allowing only 75 points this season, placing them 50th nationally. Their defensive prowess is highlighted by their ability to create turnovers, with 2 interceptions ranking them 3rd. Additionally, their defensive line has been effective with 4 sacks, showing their ability to pressure quarterbacks.
In recent games, the defense held Tulane to just 104 passing yards and forced an interception, contributing significantly to the victory. They will need to maintain this level of performance to continue their successful run.
Recent Performances
The Rebels’ recent games have been marked by impressive victories, including a thrilling 63-7 win over Georgia State. They also secured a hard-fought 41-35 victory against Arkansas, showcasing their ability to perform in close games. Their consistent performance has been a key factor in their current success.
Against Kentucky, Ole Miss demonstrated resilience, pulling off a 30-23 victory on the road. This away win reflects their capability to deliver under pressure, especially in challenging environments.
Team Betting Trends
- SU – Home Games: 27-3 (90.0%) in the last 30 games.
- SU – As Favorite: 21-3 (87.5%) in the last 24 games.
- SU – All Games: 23-5 (82.1%) in the last 28 games.
- SU – Totals ≥ 50: 22-5 (81.5%) in the last 27 games.
- ATS – Home Games: 3-0 (100.0%) in the last 3 games.
- ATS – After Win: 9-4 (69.2%) in the last 13 games.
- O/U – All Games: 3-1 (75.0%) in the last 4 games.
Key Players to Watch
Running back Kewan Lacy has been instrumental, leading the ground game with 358 rushing yards and 7 touchdowns. Lacy’s performance has been crucial, ranking 22nd in rushing yards nationally. Wide receiver Harrison Wallace III is another standout, with 343 receiving yards and 2 touchdowns.
The combination of Lacy’s rushing ability and Wallace’s receiving skills adds versatility to the Rebels’ offense. With these key players, Ole Miss is well-positioned to continue its offensive success.
LSU Tigers Set for a Showdown: Can They Roar Past Ole Miss?
Offensive Insights
The LSU Tigers have shown a strong offensive game in the 2025 season, particularly with their passing attack. Ranking 23rd in the nation, they have accumulated 1,098 passing yards so far, which underscores their ability to move the ball through the air effectively.
However, the rushing game has been less effective, ranking 98th with 476 rushing yards. This could be an area of concern as they prepare to go against Ole Miss, requiring a more balanced offensive approach.
Defensive Prowess
Defensively, LSU has been solid, allowing only 37 points against them, ranking 15th nationally. This is a testament to their ability to keep opponents’ scoring opportunities limited.
The Tigers have also excelled in pressuring opposing quarterbacks with 11 sacks, ranking them 7th in the nation. Their ability to generate turnovers, with 6 interceptions, further highlights the strength of their defense.
Quarterback Performance
Garrett Nussmeier has been instrumental in LSU’s passing success, ranking 1st among league quarterbacks with 960 passing yards. His leadership and decision-making will be crucial in the upcoming game.
Despite some interceptions, Nussmeier’s 6 passing touchdowns reflect his capacity to execute in the red zone. Keeping turnovers to a minimum will be vital for him against Ole Miss.
Team Betting Trends
- SU – Home Games: 24-2 (92.3%) over the last 26 games
- SU – As Favorite: 25-5 (83.3%) over the last 30 games
- SU – After Win: 23-6 (79.3%) over the last 29 games
- SU – All Games: 6-0 (100.0%) over the last 6 games
- SU – Totals ≥ 50: 22-8 (73.3%) over the last 30 games
These trends indicate LSU’s strong performance when playing at home and when favored, though they will need to maintain focus as they are slight underdogs on the road against Ole Miss.
Ole Miss vs LSU Prediction: Ole Miss -1.5
The Ole Miss Rebels, ranked #13 in the AP poll, are off to a strong start with a 4-0 record, including a perfect 3-0 at home. Their impressive offensive output ranks them 10th in points scored and 9th in passing yards. With a home field advantage at Vaught-Hemingway Stadium, Ole Miss looks poised to maintain their momentum.
LSU, also 4-0 and ranked #4, possesses a strong passing attack ranked 23rd. However, their rushing game lags significantly at 98th, which could be an issue against Ole Miss’s balanced defense. The Rebels have a strong track record at home, winning 90% of their last 30 games.
Ole Miss is favored by 1.5 points, and with their potent offense and dominant home performance history, they appear well-positioned to cover the spread. Their recent 45-10 victory over Tulane illustrates their capability to dominate opponents.
Given LSU’s vulnerabilities in the ground game and Ole Miss’s home dominance, the Rebels should cover the -1.5 spread. Expect a high-scoring game with Ole Miss emerging on top.
- Ole Miss vs LSU Prediction: Ole Miss -1.5
- Ole Miss vs LSU Score: Ole Miss 34 – LSU 27
