MLB Game Prediction

Cincinnati Reds vs Chicago Cubs Prediction & Betting Tips for 9/21/2025

Want our best Cincinnati Reds vs Chicago Cubs prediction for 9/21/25? Get our MLB betting tip as the Cubs travel to the Reds on 9/21/25 at Great American Ball Park, in Cincinnati. Knup Sports has your free pick!

The Chicago Cubs, under the guidance of manager Craig Counsell, are set to play an afternoon game against the Cincinnati Reds at the Great American Ball Park. Currently holding a record of 88-67, the Cubs are second in the NL Central division. However, they face a challenge as they are on a three-game losing streak with a recent loss to the Reds, 6-3.

On the other side, the Cincinnati Reds, led by manager Terry Francona, have built some momentum with a four-game winning streak. Holding a record of 79-76, the Reds sit third in the NL Central, aiming to close the gap. The Reds recently bested the Cubs in their last encounter and are looking to keep their winning streak alive.

Sunday’s game promises an exciting encounter as both teams have a 6-4 record in their last ten games. The weather forecast predicts overcast clouds with a light breeze, which might affect play at the outdoor field. Fans can catch the game on FDSOH at 1:40 PM.

Reds vs Cubs At a Glance

  • Game Location: Great American Ball Park in Cincinnati, OH — Outdoor Field
  • Current Weather: Overcast Clouds with a mild day and light breeze crosswind
  • TV Broadcast: Available on FDSOH
  • Team Records: Cubs at 88-67 (2nd in NL Central); Reds at 79-76 (3rd in NL Central)
  • Betting Odds: Cubs Moneyline: -104; Reds Moneyline: -114
  • Recent Performance: Cubs on a 3-game losing streak; Reds on a 4-game winning streak

Reds Ready to Battle Cubs: A Deep Dive into Cincinnati’s Upcoming Challenge

Chicago Cubs Overview

The Chicago Cubs enter the upcoming game against the Cincinnati Reds with a solid lineup, led by their starter, Jameson Taillon. Taillon boasts a respectable ERA of 3.93 and a WHIP of 1.09, reflecting his effectiveness on the mound. His record of 10-6 shows his ability to secure wins for the Cubs.

Offensively, the Cubs have shown potential with players capable of delivering at crucial moments. Their lineup aims to capitalize on any pitching errors and exploit the Reds’ vulnerabilities. However, their recent outings indicate some inconsistency, which could be a factor against a Reds team looking to extend their winning streak.

Key Players to Watch

For the Cubs, Jameson Taillon will be pivotal in setting the tone with his pitching performance. He’ll need to maintain his low WHIP to limit the Reds’ scoring opportunities. Offensively, the Cubs rely on contributions from their middle-order hitters to drive in runs.

The Cubs’ lineup must remain vigilant against the Reds’ pitching staff, particularly Andrew Abbott, who has been in excellent form with a 2.88 ERA. The effectiveness of players like Ian Happ and Dansby Swanson could determine the Cubs’ chances of overcoming the Reds’ momentum.

Team Statistics and Strategy

The Cubs’ batting average this season has been competitive, ranking in the middle of the league standings. Their on-base percentage also reflects their ability to get runners on base, an essential factor for generating runs against a strong Reds pitching lineup.

Defensively, the Cubs have been solid, but they will need to be sharp to counter the Reds’ recent offensive surge. Maintaining focus in key situations and avoiding errors will be crucial for the Cubs to thwart the Reds’ aggressive base running and power hitting.

Betting Trends

  • SU Last 3 Games: 2-1 (66.7%)
  • Runline Last 5: 3-2 (60.0%)
  • O/U Last 10: 4-6 (40.0%)
  • O/U as Underdog: 38-49 (43.7%)

Final Thoughts

The Cubs face a significant challenge against a Reds team on the brink of a playoff spot. With the Reds’ recent form and the pressure to secure wins, the Cubs must deliver a comprehensive performance to disrupt Cincinnati’s plans.

Ultimately, the game could come down to how well the Cubs execute under pressure and their ability to contain the Reds’ potent lineup. With both teams eyeing a strong finish to the season, expect a competitive and strategic battle at Great American Ball Park.

Cubs Seek to Rebound Against the Reds: An In-Depth Look at Chicago’s Upcoming Game

Team Overview

The Chicago Cubs have had a challenging stretch, dropping their last three games against the Cincinnati Reds. Despite their recent setbacks, the Cubs have already clinched a postseason berth, indicating their overall strong performance throughout the season.

Currently sitting at 88-67, the Cubs will look to regain momentum and break their losing streak in the upcoming game against the Reds.

Key Players to Watch

Michael Busch has been a standout performer for the Cubs this season, leading the team with 30 home runs. As the first Cub to reach this milestone since 2019, Busch’s power at the plate will be crucial for the Cubs’ offensive efforts.

Seiya Suzuki, serving as the designated hitter, has also been a significant contributor with 27 home runs and 91 RBIs. His presence in the lineup is vital for the Cubs as they aim to increase their scoring potential.

Pitching Matchup

The Cubs will start Jameson Taillon, who brings a 3.93 ERA and a WHIP of 1.09 to the mound. Taillon’s ability to control the game and limit the Reds’ offense will be key for the Cubs’ chances.

Opposing him is Andrew Abbott of the Reds, with a 2.88 ERA, making this an intriguing pitching duel. Taillon’s performance against Abbott will likely play a significant role in determining the outcome.

Hitting Stats and Trends

The Cubs rank 9th in batting average (.249) and on-base percentage (.320), showcasing their ability to consistently get on base. Additionally, their slugging percentage of .427 is the 7th best in the league, highlighting their power-hitting capabilities.

With 209 home runs this season, the Cubs rank 5th in this category, emphasizing their potential to change the game with a single swing.

Defensive and Pitching Insights

On the defensive side, the Cubs have maintained a solid 3.84 ERA, ranking them 7th in the league. This speaks to their ability to keep games within reach, even when facing potent offenses.

Despite ranking 20th in home runs given up with 193, the Cubs’ pitching staff has managed to produce 59 quality starts, indicating their starters’ reliability.

Injury Updates

The Cubs have several key players on the injured list, including Daniel Palencia (shoulder) and Justin Steele (elbow). These injuries have tested the depth of the Cubs’ roster.

As they prepare for the postseason, managing these injuries will be crucial for the Cubs to maintain their competitive edge.

Team Betting Trends

  • Straight Up Last 3 Games: 0-3 (0.0%)
  • Runline Last 10: 7-3 (70.0%)
  • O/U All Games: 71-84 (45.8%)
  • SU as Favorite: 70-41 (63.1%)
  • SU After a Loss: 44-22 (66.7%)

Reds vs Cubs Prediction: Reds -114

The Cincinnati Reds have a significant momentum heading into this game, having won four consecutive games, including three against the Cubs. The Reds have performed well at home this season with a 43-34 record, and they will look to capitalize on this advantage at the Great American Ball Park.

Andrew Abbott, with an ERA of 2.88, will be on the mound for the Reds, providing them with a solid pitching advantage over the Cubs’ Jameson Taillon, who has a higher ERA of 3.93. Abbott’s performance could be crucial in continuing the Reds’ winning streak.

The Cubs are facing a bit of a slump, having lost their last three games, and their recent struggles may continue against a Reds team that is playing well. The Reds have also dominated the season series, winning six out of the last ten matchups.

Given the Reds’ current form and home advantage, they are favored at -114 on the moneyline. We predict a close game, with the Reds edging out the Cubs with a final score of 5-3.

  • Reds vs Cubs Prediction: Reds -114
  • Reds vs Cubs Score: Reds 5 – Cubs 3
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