MLB Game Prediction

Baltimore Orioles vs New York Yankees Prediction & Betting Tips for 9/21/2025

Want our best Baltimore Orioles vs New York Yankees prediction for 9/21/25? Get our MLB betting tip as the Yankees travel to the Orioles on 9/21/25 at Oriole Park at Camden Yards, in Baltimore. Knup Sports has your free pick!

The New York Yankees, with a record of 87-68, head into their next game against the Baltimore Orioles at Oriole Park at Camden Yards. The Yankees are currently ranked second in the AL East and have shown strong recent form with a 7-3 record over their last 10 games. Under the management of Aaron Boone, they aim to continue their positive momentum.

The Baltimore Orioles, standing at 73-82, will look to turn things around as they face the Yankees at home. Despite their recent loss to the Yankees, the Orioles have managed to split their last 10 games evenly with a 5-5 record. Interim manager Tony Mansolino will lead the Orioles as they seek a better result in this outing.

This afternoon game, scheduled for September 21, 2025, will be broadcast on the YES Network. With overcast clouds and a mild breeze expected, both teams will need to adapt to the outdoor conditions at Camden Yards. The Yankees hold the edge with the sportsbook odds favoring them at -134 for the moneyline.

Orioles vs Yankees At a Glance

  • Game Location: Oriole Park at Camden Yards in Baltimore, MD
  • Game Odds: Yankees Moneyline -134, Orioles Moneyline +114
  • Weather Outlook: Overcast clouds with a mild day and light breeze
  • Yankees Record: 87-68, 2nd in AL East
  • Orioles Record: 73-82, 5th in AL East
  • TV Broadcast: YES Network

Baltimore Orioles Look to Bounce Back Against the Yankees

Team Overview

The Baltimore Orioles are currently navigating through a challenging season with a record of 73-82. Injuries and underperformance have significantly impacted their roster, highlighting the need for depth and improvement in player development. As the Orioles prepare to face the New York Yankees, they aim to finish the season on a positive note.

The Orioles’ offensive lineup has struggled, ranking 15th in batting average at .238 and 18th in on-base percentage at .305. Despite these challenges, their power-hitting capabilities are evident as they rank 10th in home runs with 181 for the season.

Pitching Challenges

Baltimore’s pitching staff has faced significant hurdles, reflected in their 24th-ranked ERA of 4.61 and a batting average against of .259, placing them 21st in the league. The Orioles have also struggled with the long ball, giving up 205 home runs, which ranks them 24th.

Kyle Bradish will start against the Yankees, holding a respectable ERA of 2.45 and a WHIP of 1.09. With a 1-1 record, Bradish is one of the bright spots in an otherwise beleaguered rotation, aiming to contain a potent Yankees lineup.

Key Players to Watch

Gunnar Henderson has been a standout for the Orioles, boasting a .275 batting average with 16 home runs and 65 RBIs. As the team’s leading run scorer with 84 runs, Henderson is pivotal to the Orioles’ offensive efforts.

Jackson Holliday, playing at second base, contributes with a .247 average, 17 home runs, and 55 RBIs. His performance will be crucial as the Orioles look to mount a competitive challenge against the Yankees.

Betting Trends

  • SU Last 3 Games: 1-2 (33.3%)
  • SU Last 5 Games: 3-2 (60.0%)
  • SU Last 10 Games: 5-5 (50.0%)
  • Runline Last 3: 1-2 (33.3%)
  • Runline Last 5: 2-3 (40.0%)
  • Runline Last 10: 4-6 (40.0%)
  • O/U Last 3: 0-3 (0.0%)
  • O/U Last 5: 1-4 (20.0%)
  • O/U Last 10: 3-7 (30.0%)

Injury Report

The Orioles have been hampered by injuries, with key players like Adley Rutschman and Zach Eflin sidelined. Rutschman is expected to return from an oblique strain soon, while Eflin will miss the remainder of the season due to a back injury.

Additionally, the pitching staff faces further setbacks with Grayson Rodriguez and Félix Bautista both out for the season, leaving the Orioles with limited options in their rotation and bullpen.

Yankees’ Road Challenge: A Preview of the Orioles

Orioles’ Offensive Outlook

The Baltimore Orioles have shown a strong batting presence this season, with a team batting average of .250, ranking them 8th in the league. Their on-base percentage of .330 stands out, placing them 3rd overall, showcasing their ability to get on base and create scoring opportunities. The team’s slugging percentage of .454 is the highest in the league, highlighting their power-hitting capabilities.

Home runs have been a significant part of their offensive arsenal, with the Orioles hitting 261 homers, the most in the league. Their ability to drive the ball for extra bases is further evidenced by their 247 doubles, which ranks them 12th. However, their strikeout rate is a concern, as they rank 28th with 1,391 strikeouts, indicating a high propensity for swings and misses.

Key Orioles Players

Leading the charge for the Orioles’ offense is a lineup that can change the game’s dynamics with one swing. Players like Ryan Mountcastle and Anthony Santander have been pivotal with their consistent power hitting. Both have contributed significantly to the team’s high home run and slugging numbers.

The Orioles’ lineup also benefits from the plate discipline of Cedric Mullins, whose ability to get on base is crucial for setting the table. His speed adds another dimension, with the Orioles ranking 7th in stolen bases with 132. This blend of power and speed makes the Orioles a versatile threat on the base paths.

Pitching Strengths and Weaknesses

On the pitching front, the Orioles have maintained a respectable team ERA of 4.00, placing them in the middle of the league at 16th. Their batting average against is an impressive .231, ranking 4th, which reflects their ability to limit opposing hits effectively.

However, the long ball has been a challenge for the Orioles, having given up 167 home runs, placing them 9th in the league. Their bullpen has shown some vulnerability with 21 blown saves, ranking 4th, which could be a factor in close games.

Orioles’ Starting Pitcher

Kyle Bradish will take the mound for the Orioles, bringing a solid ERA of 2.45 and a WHIP of 1.09. His record of 1-1 indicates limited decision outcomes, but his ability to keep the opposition’s batting average low suggests he can control the game’s tempo.

Bradish’s performance will be critical in containing the Yankees’ potent lineup, particularly in neutralizing power threats like Aaron Judge and Giancarlo Stanton. His success will hinge on mixing pitches effectively and maintaining command to avoid costly mistakes.

Baltimore Orioles Betting Trends

  • Home Record: The Orioles perform better at home, utilizing familiar conditions to their advantage.
  • Against Division Rivals: Games against divisional opponents have been competitive, reflecting the intensity of intra-division matchups.
  • Under Pressure: The Orioles have shown resilience in close games, often turning the tide in late innings.

Orioles vs Yankees Prediction: ‘Under 8.5’

The New York Yankees and Baltimore Orioles are set to meet with a total set at 8.5. Given the current performance trends, this game is likely to lean towards the under. Baltimore’s last 10 games show a 3-7 over/under record, indicating a tendency toward lower-scoring outcomes.

Cam Schlittler, starting for the Yankees, has a solid ERA of 3.41, which suggests he can limit the Orioles’ run production. Additionally, Kyle Bradish for Baltimore sports an impressive 2.45 ERA, further pointing towards a low-scoring battle. Both teams’ recent performances support the likelihood of a game under the set total.

Considering the Yankees’ recent strong pitching, holding Baltimore to minimal runs in the previous game, the under seems a prudent choice. The Orioles’ offensive struggles, particularly in games against quality pitching, further reinforce this prediction.

In a match featuring capable pitchers and an Orioles lineup struggling to score, expect a close game with limited scoring opportunities. Projecting a final score in favor of New York, the Yankees might edge out the Orioles 4-2.

  • Orioles vs Yankees Prediction: ‘Under 8.5’
  • Orioles vs Yankees Score: ‘Yankees 4 – Orioles 2’
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