MLB Game Prediction

St. Louis Cardinals vs Milwaukee Brewers Prediction & Betting Tips for 9/19/2025

Want our best St. Louis Cardinals vs Milwaukee Brewers prediction for 9/19/25? Get our MLB betting tip as the Brewers travel to the Cardinals on 9/19/25 at Busch Stadium, in St. Louis. Knup Sports has your free pick!

The Milwaukee Brewers, currently leading the NL Central with a record of 94-59, will head to Busch Stadium to play against the St. Louis Cardinals. The Brewers are in strong form with a three-game winning streak and have gone 6-4 in their last 10 games. Managed by Pat Murphy, the team looks to continue their successful run on the road where they boast a 43-32 record.

On the other side, the St. Louis Cardinals find themselves in a more challenging situation, sitting fourth in the NL Central with a record of 74-79. Despite a recent loss to the Cincinnati Reds, the Cardinals have a decent home record of 42-36. Oliver Marmol’s team will aim to bounce back and improve their 3-7 performance over the last 10 games.

This game is set for Friday, September 19, 2025, at 8:15 PM at Busch Stadium. Fans can catch the live broadcast on FDSMW. Expect very hot weather with calm winds and overcast skies as these division rivals meet once again.

Cardinals vs Brewers At a Glance

  • Game Location: Busch Stadium, St. Louis, MO
  • Weather Conditions: Overcast clouds with calm wind, very hot
  • Brewers Current Standings: 94-59, leading the NL Central, on a 3-game win streak
  • Cardinals Current Standings: 74-79, 4th in the NL Central, following a loss
  • Game Odds: Brewers are favored with a -118 moneyline; Cardinals at +100
  • Broadcast Info: Tune in on FDSMW for live coverage

The Cardinals Prepare to Host the Brewers: A Game Preview

Milwaukee Brewers Overview

The Milwaukee Brewers head into their game against the St. Louis Cardinals with a solid performance from their starting pitcher Jacob Misiorowski. Misiorowski holds a 4.35 ERA and a WHIP of 1.13, indicating a reliable presence on the mound.

With a 5-2 win-loss record, Misiorowski has shown the ability to secure victories and control games effectively. His performance will be crucial as the Brewers aim to challenge the Cardinals on their home turf.

Team Batting Analysis

The Brewers’ lineup has recorded a batting average of .244, placing them 12th in the league. Their ability to get on base with an OBP of .312 ranks them 15th, demonstrating a moderately consistent offense.

In terms of power, Milwaukee has hit 142 home runs, placing 20th in the league. While they may not lead in long balls, their 243 doubles rank 13th, showing they can still produce extra-base hits.

Pitching Staff Performance

The Brewers’ pitching staff has been slightly above average with a 4.30 ERA, ranking 21st. Their batting average against is .258, ranking 18th, suggesting that opposing hitters find some success.

On the defensive side, Milwaukee’s pitchers have given up 156 home runs, the fourth-most in the league. However, they have managed to rack up 53 quality starts, ranking 11th, showing that their starters can go deep into games effectively.

Key Players to Watch

Jacob Misiorowski, the Brewers’ starting pitcher, will be a focal point. His ability to limit hits and control the game could be pivotal for Milwaukee’s success.

Offensively, the Brewers rely on their doubles and home runs to generate runs. Watch for their lineup to try to exploit the Cardinals’ pitching, aiming for big innings.

Milwaukee Brewers Betting Trends

  • SU in Away Games: 32-43 (42.7%)
  • Runline as Underdog: 51-36 (58.6%)
  • O/U Totals ≥ 9: 20-22 (47.6%)
  • O/U as Underdog: 42-45 (48.3%)
  • O/U in Away Games: 38-37 (50.7%)

Brewers Look to Continue Dominance Against Cardinals

Team Overview

The Milwaukee Brewers have been on a roll, demonstrating exceptional performance both at the plate and on the mound. They boast a .261 team batting average, which ranks second in the league, and a .333 on-base percentage, also placing them second. Their pitching staff has been equally impressive, holding a 3.60 ERA, ranking second in the league, and limiting opponents to a .229 batting average.

One of the standout aspects of the Brewers’ play is their ability to capitalize on offensive opportunities. With 533 walks, they rank third in the league, showing their patience at the plate. Additionally, their 155 stolen bases rank second, illustrating their aggressive base-running strategy.

Key Players to Watch

Christian Yelich continues to be a key figure in the Brewers’ lineup, recently reaching the milestone of 100 RBIs for the season. His offensive contributions have been instrumental in the team’s success, particularly during their recent sweep of the Angels. Yelich’s ability to drive in runs and get on base will be crucial against the Cardinals.

Brice Turang, the Brewers’ second baseman, is having an outstanding season with a .289 batting average and 18 home runs. His consistent performance at the plate, coupled with 95 runs, makes him a vital component of Milwaukee’s offensive strategy. Turang’s ability to get on base and create scoring opportunities will be key in this series.

Pitching Matchup

Jacob Misiorowski takes the mound for the Brewers with a 4.35 ERA and a WHIP of 1.13. His record of 5-2 demonstrates his capability to secure wins for Milwaukee. Misiorowski’s performance will be crucial in maintaining the Brewers’ strong pitching presence.

Facing Misiorowski will be Sonny Gray of the Cardinals, who holds a 4.43 ERA. With Gray’s 13-8 record, the Brewers’ hitters will need to be aggressive and capitalize on any mistakes he makes to continue their offensive momentum.

Brewers’ Recent Success

The Brewers are coming off a dominant series against the Los Angeles Angels, where they showcased their all-around strength. They secured a 5-2 victory in their most recent game, with strong performances from their lineup and pitching staff. This momentum is critical as they face a divisional rival in the Cardinals.

Quinn Priester’s outstanding performances have been a significant factor in the Brewers’ recent success. The team has won 19 consecutive games when Priester starts, highlighting his impact on the mound. While Priester isn’t starting this game, his influence on the team’s morale and confidence is notable.

Brewers’ Betting Trends

  • SU Last 3 Games: 3-0 (100.0%)
  • Runline in Away Games: 48-27 (64.0%)
  • O/U Last 10: 7-3 (70.0%)
  • SU as Underdog: 36-27 (57.1%)
  • SU After a Win: 60-34 (63.8%)

As the Brewers face the Cardinals, their strong form and impressive betting trends indicate they are well-prepared to continue their winning ways. With key players in form and a robust team performance, Milwaukee is poised to extend their successful run.

Cardinals vs Brewers Prediction: Over 7.5

The Milwaukee Brewers come into this game with a strong record and an impressive recent form, having won three games consecutively. With their offense ranking second in batting average and strong overall performance, they have the potential to put up significant runs. Additionally, Christian Yelich’s offensive prowess, evidenced by his 100 RBIs this season, bolsters the Brewers’ ability to score.

The St. Louis Cardinals, while not as dominant as the Brewers, have been capable of putting up runs as well. Their home performance this season has been solid with a 42-36 record at Busch Stadium. Despite their struggles, they have a chance to contribute to a higher-scoring game, especially with Sonny Gray on the mound who has a 4.43 ERA.

Both starting pitchers, Jacob Misiorowski for the Brewers and Sonny Gray for the Cardinals, have ERAs over 4.00, suggesting they are susceptible to allowing runs. This aligns with the trend of higher-scoring games in recent head-to-head matchups between these teams. The Brewers’ ability to score in bunches and the Cardinals’ occasional offensive bursts suggest a potential for an over.

The weather conditions, described as overcast but very hot, could also influence the ball to travel well, potentially aiding hitters. Considering the recent head-to-head outcomes and both teams’ offensive capabilities, the pick is for the total to go over 7.5.

  • Cardinals vs Brewers Prediction: Over 7.5
  • Cardinals vs Brewers Score: Brewers 6 – Cardinals 3
To Top