NFL Game Prediction

Titans vs Colts Prediction & Betting Tips for NFL Week 3 on 9/21/2025

Want our best Titans vs Colts prediction for NFL week 3 on 9/21/25? Get our NFL betting tip as the Indianapolis Colts travel to the Tennessee Titans on 9/21/25 at Nissan Stadium, in Tennessee. Knup Sports has your free pick!

The Indianapolis Colts will travel to Nissan Stadium in Nashville, TN to face the Tennessee Titans in a 2025 Week 3 matchup. The game is scheduled for Sunday, September 21, at 1:00 PM and will be broadcast on CBS. Fans can expect light rain with mild weather conditions during this outdoor event.

Under the leadership of head coach Shane Steichen, the Colts enter the game with a perfect 2-0 record. They showcased their offensive strength in previous games, defeating the Denver Broncos and Miami Dolphins. Key players like Jonathan Taylor and Daniel Jones have been instrumental in their victories.

The Titans, led by head coach Brian Callahan, are still seeking their first win of the season with a 0-2 record. Their recent losses to the Los Angeles Rams and Denver Broncos have highlighted areas needing improvement. Playing at home might provide the Titans with the opportunity to turn their season around against a divisional rival.

Titans vs Colts At a Glance

  • Stadium and Location: The game will be held at Nissan Stadium in Nashville, TN.
  • Weather Conditions: Expect a mild day with ‘Light Rain’.
  • TV Coverage: The game will be broadcasted on CBS.
  • Indianapolis Colts Record: The Colts are currently 2-0-0 this season.
  • Tennessee Titans Record: The Titans hold a 0-2-0 record so far this season.
  • Game Odds: Colts are favored with a -197 moneyline and a -3.5 spread.

Tennessee Titans: A Closer Look at the Numbers

Team Offense Analysis

The Tennessee Titans have struggled offensively this season, ranking 25th in the league with a total score of 311 points. Their passing game has been underwhelming, with only 3317 passing yards, placing them at 26th in the NFL.

On the ground, they are slightly better, rushing for 1855 yards and ranking 19th. Despite these numbers, their 309 first downs place them 22nd, reflecting inconsistency in sustaining drives.

Team Defense Overview

Defensively, the Titans have allowed 460 points, ranking 27th in the league. However, they have performed well in certain areas, recording 32 sacks to place 16th.

They have excelled at creating turnovers, with 11 interceptions and 6 fumbles recovered, both ranked 9th. Despite this, they have allowed a substantial 5291 opponent offensive yards, making them 2nd worst in the league.

Recent Performance

In their most recent game against the Los Angeles Rams, the Titans lost 33-19. Their passing game contributed just 143 yards, which was significantly less than the Rams’ 290 yards.

The Titans also struggled on the ground, managing 109 rushing yards compared to the Rams’ 149. Additionally, they fumbled twice, a costly factor in their loss.

Key Players and Injuries

Quarterback Cameron Ward has thrown for 287 yards over two games, ranking 28th in the league. Running back Tony Pollard has been a bright spot with 152 rushing yards, ranking 6th.

Injuries have plagued the Titans, with key players like Treylon Burks and Will Levis out for the season. This has undoubtedly impacted their overall performance and depth.

Betting Trends

  • O/U – Home Games (REG): Last 3 REG Games (2024–2025) → 3-0 (100.0%)
  • O/U – As Underdog (REG): Last 10 REG Games (2024–2025) → 8-2 (80.0%)
  • O/U – Away Games (REG): Last 8 REG Games (2024–2025) → 6-2 (75.0%)
  • O/U – All Games (REG): Last 14 REG Games (2024–2025) → 9-5 (64.3%)
  • ATS – As Underdog (REG): Last 3 REG Games (2024–2025) → 1-2 (33.3%)
  • SU – All Games (REG): Last 12 REG Games (2024–2025) → 2-10 (16.7%)

Indianapolis Colts Seek to Extend Winning Streak Against Tennessee Titans

Quarterback Performance

Daniel Jones has been the driving force for the Colts’ offense, recording 588 passing yards in the first two games of the season. His ability to avoid turnovers, with zero interceptions, has been crucial to the Colts’ success. Ranked 1st in the league for passing yards among quarterbacks, Jones continues to be a consistent performer.

Rushing Attack

The Colts’ rushing game is spearheaded by Jonathan Taylor, who leads the league with 236 rushing yards in two games. Despite not finding the end zone yet, Taylor’s contributions have been essential in controlling the game tempo. Additionally, his receiving capabilities add a versatile dimension to the offense.

Receiving Corps

Michael Pittman Jr. and Tyler Warren have been key targets for Jones, with Pittman Jr. amassing 120 receiving yards and a touchdown. Tight end Tyler Warren has also been effective, with 155 receiving yards. Their performances have been pivotal in maintaining offensive momentum.

Defense and Turnovers

The Colts’ defense has shown its strength by recovering 10 fumbles and intercepting 16 passes, ranking among the top teams in these categories. The defensive line, led by DeForest Buckner, has been effective in applying pressure, recording 36 sacks. These defensive stats are critical in turning over possession and providing offensive opportunities.

Special Teams

Spencer Shrader has been reliable, converting nine field goals to lead the league. His consistency in both field goals and extra points has provided the Colts with crucial points. This special teams performance supports the Colts in close-game scenarios.

Recent Game Highlights

In their recent outing, the Colts edged the Denver Broncos 29-28, demonstrating resilience in a tightly contested game. Jonathan Taylor’s rushing and Daniel Jones’ passing were instrumental in securing this victory. The Colts’ defense also held strong against a competitive Broncos team.

Team Injury Report

The Colts face some injury challenges, with several players on injured reserve, including D.J. Montgomery and Salvon Ahmed. However, the questionable status of players like Charvarius Ward and Tyler Goodson may impact game strategy. Depth and adaptability will be key in navigating these injuries.

Betting Trends

  • O/U – After Loss (REG): Last 5 REG Games (2024) → 5-0 (100.0%)
  • SU – Home Games (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
  • ATS – Home Games (REG): Last 4 REG Games (2024–2025) → 4-0 (100.0%)
  • O/U – Away Games (REG): Last 4 REG Games (2024) → 4-0 (100.0%)
  • SU – After Loss (REG): Last 4 REG Games (2024) → 4-0 (100.0%)

Titans vs Colts Prediction: Colts -3.5

The Indianapolis Colts head into Week 3 with a strong start to their season, boasting a 2-0 record. Despite playing on the road, the Colts are favored by 3.5 points, which is justified given their performance last season and the early momentum this year.

The Titans, on the other hand, are struggling with an 0-2 record and a poor showing in recent games, both straight-up and against the spread. The Colts’ robust defense, which ranked 4th in passing interceptions last season, can capitalize on the Titans’ offensive challenges.

Given the Colts’ recent head-to-head success against the Titans, including covering the spread in their last two encounters, Indianapolis appears well-positioned to cover the spread once again. The light rain forecasted should not deter the Colts’ balanced offensive attack.

With the Colts’ effective mix of ground and aerial offense, a projected score of Colts 27 – Titans 20 aligns with taking the Colts to cover the spread at -3.5. Their superior record and better team stats further reinforce this prediction.

  • Titans vs Colts Prediction: Colts -3.5
  • Titans vs Colts Score: Colts 27 – Titans 20
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