MLB Game Prediction

St. Louis Cardinals vs Cincinnati Reds Prediction & Betting Tips for 9/17/2025

Want our best St. Louis Cardinals vs Cincinnati Reds prediction for 9/17/25? Get our MLB betting tip as the Reds travel to the Cardinals on 9/17/25 at Busch Stadium, in St. Louis. Knup Sports has your free pick!

The Cincinnati Reds, managed by Terry Francona, head into an afternoon game against the St. Louis Cardinals with a record of 75-76 and sitting third in the NL Central. Their recent performance has been evenly split, with a 5-5 record over the last ten games. Following a 3-0 loss to the Cardinals, the Reds are eager to bounce back at Busch Stadium.

St. Louis Cardinals, under the leadership of manager Oliver Marmol, hold a record of 74-78 and rank fourth in the NL Central. They enter this game on a positive note after securing a 3-0 victory against the Reds. With a 4-6 record over their last ten games, the Cardinals will look to continue their recent success at home.

Busch Stadium, known for its outdoor field, will be the venue for this contest, set to be aired on FDSMW. The weather forecast indicates a mild day with calm winds under ‘broken clouds’. The odds slightly favor the Reds with a moneyline of -112 compared to the Cardinals’ -106, suggesting a closely contested game.

Cardinals vs Reds At a Glance

  • Game Location: Busch Stadium in St. Louis, MO
  • Current Records: Reds 75-76, Cardinals 74-78
  • Division Standings: Reds 3rd in NL Central, Cardinals 4th
  • Weather Outlook: Mild with ‘Broken Clouds’ and calm winds
  • Broadcast Information: Watch on FDSMW
  • Betting Odds: Reds Moneyline -112, Cardinals Moneyline -106

Cardinals Seek to Build Momentum Against the Reds

Reds’ Offensive Profile

The Cincinnati Reds have demonstrated a solid offensive profile with a batting average of .245, ranking 9th in the league. Despite their lower on-base percentage ranking at 14th, they show resilience with 242 doubles, placing them 12th.

Their home run production, however, ranks 26th, signaling a need for improvement in power hitting. The Reds’ ability to generate offense will be critical in their matchup against the Cardinals.

Key Players to Watch

Brady Singer leads the Reds’ rotation with a respectable ERA of 3.94 and a WHIP of 1.24. His 13-10 win-loss record reflects his capability to deliver under pressure, making him a pivotal figure in their pitching strategy.

Reds’ offense will rely heavily on their ability to create scoring opportunities, supported by their league ranking of 12th in doubles. Consistency from key hitters will be crucial for overcoming the Cardinals’ pitching.

Pitching Concerns

Cincinnati’s pitching staff ranks 21st in earned run average at 4.30, showing room for improvement in run prevention. They have allowed 155 home runs, ranking 4th, which may become a vulnerability against a Cardinals lineup capable of capitalizing on such weaknesses.

With only 53 quality starts, the Reds will look to Brady Singer to extend his outings and reduce the pressure on their bullpen. The ability of the pitching staff to maintain composure will be tested against the Cardinals’ hitters.

Defensive Challenges

Defensively, the Reds allow a batting average against of .258, ranking them 17th. This indicates potential challenges in containing high-caliber offenses like the Cardinals.

Their bullpen’s efficiency will be a focal point, especially with 22 blown saves, ranking them 6th in the league. Closing out games remains a key area for improvement.

Team Betting Trends

  • Runline as Underdog: 51-35 (59.3%)
  • Runline in Away Games: 38-37 (50.7%)
  • SU in Away Games: 32-43 (42.7%)
  • O/U in Away Games: 38-37 (50.7%)
  • Runline when Scoring 5+: 49-17 (74.2%)

The Cincinnati Reds Prepare for Showdown Against the Cardinals

Team Overview

The Cincinnati Reds are gearing up for an important game against the St. Louis Cardinals. With a current record of 75-76, they are striving to bounce back after a challenging stretch. Currently three games behind in the National League wild card race, the Reds are focused on closing the gap.

The Reds’ hitting lineup has shown potential this season, ranking 9th in batting average at .245. However, their power numbers are lagging slightly, with a slugging percentage of .391, placing them 17th in the league. Their ability to capitalize on scoring opportunities will be crucial in this game.

Key Players to Watch

Elly De La Cruz stands out as a key player, boasting a batting average of .264 with 19 home runs and 82 RBIs. His performance at shortstop has been pivotal, leading the team in several offensive categories. His presence in the lineup is vital for the Reds’ success.

Spencer Steer, playing first base, contributes with a .237 average and 17 home runs. Despite recent neck spasms, his power at the plate makes him a significant threat. The Reds will be counting on him to provide some much-needed offense.

Pitching Matchup

Brady Singer takes the mound for the Reds with a 13-10 record and a 3.94 ERA. His consistency and ability to control games will be essential against the Cardinals’ lineup. Singer’s performance could dictate the outcome of the game.

On the opposing side, the Cardinals will rely on Andre Pallante, who has struggled this season with a 6-14 record and a 5.34 ERA. The Reds will look to exploit Pallante’s vulnerabilities and capitalize on scoring opportunities.

Recent Performance

The Reds’ recent games have been a mix of highs and lows, highlighted by a notable 11-6 win against the Cardinals. However, consistency has been a challenge, as evidenced by losses like the 3-0 defeat to the Cardinals and a 7-4 loss to the Athletics. Improving performance in tight games is crucial for the Reds.

In these matchups, Elly De La Cruz and Tyler Stephenson have shown their potential, providing offensive sparks in key moments. As they prepare for the upcoming game, maintaining focus and execution will be critical.

Betting Trends

  • SU Last 3 Games: 1-2 (33.3%)
  • SU in Away Games: 35-42 (45.5%)
  • Runline as Underdog: 52-34 (60.5%)
  • O/U Last 10: 3-7 (30.0%)

Cardinals vs Reds Prediction: Over 8.5

Analyzing the matchup between the Reds and Cardinals, it’s clear the Cardinals’ recent offensive surge could play a significant role. The Cardinals are coming off a shutout win but have displayed the ability to score in bunches, as seen in their 11-6 loss to the Reds two games prior. Despite inconsistent performances, their potential to rack up runs remains high.

On the mound, Andre Pallante’s ERA of 5.34 indicates struggles with run prevention, which the Reds could exploit. Conversely, Brady Singer’s performance has been steady, yet against an unpredictable Cardinals lineup, there is a chance he could give up more than expected. Both teams’ offensive capabilities and pitching vulnerabilities suggest a game where runs could come easily.

Historical data supports a high-scoring outcome, with 6 of the last 10 matchups between these teams going over the total. Furthermore, Busch Stadium’s conditions, with mild weather and wind blowing out, may aid in carrying balls further, thus favoring hitters. This aligns with a projection that tips the scales towards the over.

A projected final score of Reds 7, Cardinals 4 supports the over prediction. Both teams have the offensive depth to push the total over 8.5, making this a likely outcome in what could be a more open game than expected.

  • Cardinals vs Reds Prediction: Over 8.5
  • Cardinals vs Reds Score: Reds 7 – Cardinals 4
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