In Week 4 of the 2025 regular season, the Wyoming Cowboys, representing the Mountain West Conference, are set to play against the Colorado Buffaloes of the Big 12. The game will unfold at Folsom Field in Boulder, CO, offering an outdoor experience under the lights, with a 10:15 PM kickoff time on September 20, 2025. The game will be broadcast on ESPN, providing prime exposure for both teams. The Cowboys enter the game with a 2-1 record, having recently suffered a 31-6 loss to the Utah Utes. However, they secured victories against Northern Iowa and Akron in the previous weeks, showcasing a balanced offensive strategy with solid performances both in passing and rushing. On the road, they have maintained a strong presence, winning their only away game so far this season. On the other hand, the Buffaloes are looking to improve their standing with a current 1-2 record, coming off a 36-20 defeat by the Houston Cougars. Their season opener at Folsom Field ended in a close loss to Georgia Tech, but they bounced back in Week 2 with a convincing win over Delaware. As they return home for this matchup, the Buffaloes aim to leverage their home field advantage to even their season record.
Colorado vs Wyoming At a Glance
- Game Location: Folsom Field in Boulder, CO
- Game Date & Time: Saturday, September 20, 2025, at 10:15 PM
- Television Broadcast: ESPN
- Wyoming Cowboys Record: 2-1 overall, 1-0 on the road
- Colorado Buffaloes Record: 1-2 overall, 1-1 at home
- Betting Odds: Colorado favored with a -499 moneyline, and a spread of -13.5
Colorado Buffaloes: A Rocky Mountain Showdown Awaits
Offensive Performance
The Colorado Buffaloes have had a mixed start to their 2025 season. They have scored 71 points, placing them 57th in the national rankings. With 630 passing yards and 377 rushing yards, they rank 74th and 91st respectively, indicating a balanced yet modest offensive approach.
Their passing attack, led by quarterbacks like Ryan Staub, shows potential but has room for improvement. Staub’s performance so far includes 361 passing yards, ranking him 114th nationally.
Defensive Struggles
On the defensive end, the Buffaloes have allowed 70 points, positioning them 55th in the rankings. However, they have shown strength with 5 sacks, placing them 10th, and a commendable 3rd in interceptions and fumbles recovered.
Their defense will need to tighten up, especially against the run, as they have struggled against teams with a strong rushing attack, such as Georgia Tech and Houston.
Key Players to Watch
Running back Simeon Price has made an impact with 136 rushing yards and a touchdown. His contributions have been vital in maintaining offensive balance.
Wide receiver Sincere Brown leads the team with 135 receiving yards and a touchdown. His ability to create big plays can be a game-changer for the Buffaloes.
Upcoming Challenges
Looking ahead, Colorado faces a challenging schedule with matchups against the Wyoming Cowboys and BYU Cougars. Both games will test the Buffaloes’ ability to bounce back from recent losses.
With injuries plaguing key defensive players like Samuel Okunlola and Jehiem Oatis, the Buffaloes must rely on their depth to fill these gaps effectively.
Betting Trends
- SU – As Favorite: Last 11 Games (2021–2025) → 10-1 (90.9%)
- SU – After Loss: Last 5 Games (2024–2025) → 5-0 (100.0%)
- ATS – Totals ≥ 50: Last 9 Games (2024–2025) → 7-2 (77.8%)
- O/U – As Underdog: Last 24 Games (2022–2025) → 16-8 (66.7%)
- ATS – Home Games: Last 11 Games (2023–2025) → 8-3 (72.7%)
Wyoming Cowboys Prepare for the Challenge on the Road
Offensive Overview
Wyoming’s offense has struggled to find consistency in the 2025 season. The Cowboys have scored only 47 points, ranking them 73rd in the nation. Their passing game is particularly concerning with just 558 yards, placing them at 91st.
The rushing attack has shown more promise, accumulating 477 yards and ranking 63rd. However, converting these rushing yards into points has been a challenge. Wyoming’s ability to gain first downs has been relatively strong, with 59 first downs ranking 28th.
Defensive Strengths
Defensively, Wyoming has been effective in containing opponents, allowing 38 points, which ranks them 24th. The Cowboys have been aggressive in pressuring quarterbacks, recording six sacks, placing them 9th. Their secondary has also been opportunistic with three interceptions, ranking 4th nationally.
One area of concern for the Cowboys is their ability to recover fumbles, with only one recovery ranking them 5th. Maintaining defensive intensity will be key for Wyoming as they hit the road.
Injury Concerns
Wyoming’s injury list could impact their performance, with Caleb Robinson and Dante Drake both out for the season due to Achilles injuries. The offense might miss the contributions of Nico Hamilton, who is questionable with an arm injury. Tight end John Michael Gyllenborg’s status is also uncertain due to an undisclosed issue.
The loss of key players like Patrick Broadway II, who is out with a knee injury, could limit Wyoming’s offensive options. Depth and adaptability will be crucial for the Cowboys moving forward.
Key Players to Watch
Quarterback Kaden Anderson has been a bright spot, leading the Cowboys with 535 passing yards. His decision-making will be critical in guiding the team. Running back Sam Scott provides a reliable rushing option with 203 yards, ranking 73rd nationally.
Chris Durr stands out among the receivers, with 284 receiving yards placing him 18th in the country. His ability to stretch the field could be pivotal for Wyoming’s offensive success.
Wyoming Top Betting Trends
- ATS – After Loss: Last 6 Games (2024) → 6-0 (100.0%)
- SU – As Favorite: Last 15 Games (2022–2025) → 13-2 (86.7%)
- O/U – Totals ≤ 42: Last 10 Games (2021–2024) → 9-1 (90.0%)
- ATS – Totals ≥ 50: Last 5 Games (2024) → 5-0 (100.0%)
- ATS – All Games: Last 9 Games (2024–2025) → 7-2 (77.8%)
- ATS – As Underdog: Last 8 Games (2024–2025) → 6-2 (75.0%)
- ATS – Away Games: Last 5 Games (2024–2025) → 4-1 (80.0%)
Colorado vs Wyoming Prediction: Colorado -13.5
In their upcoming game against the Wyoming Cowboys, the Colorado Buffaloes are set as -13.5-point favorites. Despite their recent loss to Houston, the Buffaloes have a strong history of bouncing back after a defeat. They have shown a remarkable ability to perform well as favorites, with a 10-1 record in such situations over the past few seasons.
Colorado has been impressive at home, posting an 8-3 against the spread (ATS) record over their last 11 home games. This trend suggests they have a solid chance of covering the spread against Wyoming. The Buffaloes have also performed well after a loss, going 5-0 in their last five such situations, adding confidence in their capability to rebound strongly.
Wyoming, on the other hand, has been less consistent, particularly in their passing game, ranking 91st this season. Their road performance is modest, and facing a motivated Colorado team at Folsom Field could prove challenging. The Buffaloes’ defensive capabilities, ranked 55th in points against, should help keep Wyoming’s offense in check.
Considering these factors, it seems likely that Colorado will win comfortably and cover the -13.5 spread. Their ability to capitalize on home-field advantage and recover swiftly from setbacks positions them well for this matchup.
- Colorado vs Wyoming Prediction: Colorado -13.5
- Colorado vs Wyoming Score: Colorado 31 – Wyoming 14
