MLB Game Prediction

Cleveland Guardians vs Chicago White Sox Prediction & Betting Tips for 9/12/2025

Want our best Cleveland Guardians vs Chicago White Sox prediction for 9/12/25? Get our MLB betting tip as the White Sox travel to the Guardians on 9/12/25 at Progressive Field, in Cleveland. Knup Sports has your free pick!

The Chicago White Sox, currently holding a 57-90 record and ranked fifth in the AL Central, travel to Progressive Field to take on the Cleveland Guardians. The White Sox are on a two-game winning streak and have performed well in their last 10 games, with an 8-2 record. Managed by Will Venable, they aim to continue their positive momentum against division rivals.

The Cleveland Guardians, with a 75-71 record, are positioned second in the AL Central and have shown consistent performance with a 7-3 record in their last 10 games. With Stephen Vogt at the helm, the Guardians have been solid at home, boasting a 38-34 record at Progressive Field. This game provides another opportunity for them to strengthen their position in the division.

Scheduled for September 12, 2025, at 7:10 PM, this game will be played under clear skies with a light breeze, providing ideal conditions for baseball. The odds favor the Guardians with a moneyline of -172, while the White Sox are at +145. The total runs are set at 7.5, indicating expectations for a competitive game under the Friday night lights.

Guardians vs White Sox At a Glance

  • Game Location: Progressive Field in Cleveland, OH
  • Weather: Clear skies with a light breeze; warm evening expected
  • TV Broadcast: Available on CLEG
  • White Sox Record: 57-90, currently 5th in AL Central
  • Guardians Record: 75-71, currently 2nd in AL Central
  • Betting Odds: White Sox +145, Guardians -172

Guardians Look to Continue Winning Ways Against White Sox

White Sox Offense Overview

The Chicago White Sox have struggled offensively this season, with a team batting average of .225, ranking 20th in the league. Their on-base percentage of .295 places them 19th, indicating a need for improvement in getting players on base. Slugging percentage, a measure of power, is also lacking at .369, ranking 25th.

Despite these struggles, the White Sox have managed to hit 149 home runs, placing them in 17th position for long balls. Doubles have also been a mixed bag, with a total of 213 ranking them 21st. Walks remain a bright spot, with 445 ranking them 18th in the league.

Key White Sox Players to Watch

The White Sox rely heavily on their ability to steal bases, with 112 stolen bases ranking them 12th. This aspect of their game could be pivotal against the Guardians. However, their 1209 strikeouts rank them 14th, indicating a high tendency for swinging and missing at the plate.

Martín Pérez will take the mound for the White Sox, boasting a 3.15 ERA and a WHIP of 1.07. His record may stand at 1-4, but his ability to limit base runners could be a significant factor in this game. The White Sox will need their pitcher to be at his best to contain the Guardians’ offense.

White Sox Pitching Staff

Overall, the White Sox pitching staff has performed admirably, with a team ERA of 3.86, ranking 9th in the league. Their batting average against of .243 places them 10th, suggesting that they can effectively limit opposition hitting. However, they have given up 156 home runs, also ranking 10th.

Their pitching staff has achieved 48 quality starts, ranking 14th, which is crucial for long-term success. However, with 19 blown saves, ranking them 3rd, the bullpen might be a weak point that the Guardians can exploit in later innings.

Betting Trends for the White Sox

  • SU in Last 5 Games: 2-3
  • Runline Last 5: 2-3
  • O/U Last 5: 3-2
  • SU in Away Games: 37-37 (50.0%)
  • Runline in Away Games: 44-30 (59.5%)
  • O/U in Away Games: 32-42 (43.2%)

Chicago White Sox Look to Continue Momentum Against the Guardians

Offensive Overview

The Cleveland Guardians have struggled at the plate this season, ranking 17th in both batting average (.236) and on-base percentage (.304). Their slugging percentage is particularly low at .378, placing them 24th in the league.

Despite these challenges, the team has managed to hit 150 home runs, ranking 16th. Their ability to generate extra-base hits, including 228 doubles, has been a highlight in an otherwise underwhelming offensive performance.

Key Players to Watch

One of the Guardians’ standout performers this season has been their pitcher, Tanner Bibee. With an ERA of 4.69 and a WHIP of 1.29, Bibee has shown flashes of potential despite his 9-11 win-loss record.

His performance against the White Sox will be critical, especially as the Guardians aim to suppress Chicago’s recent offensive surge. Bibee’s ability to manage Chicago’s hitters could significantly influence the game’s outcome.

Defensive and Pitching Analysis

On the pitching side, Cleveland has given up 166 home runs, ranking them 14th in this category. Their overall team ERA stands at 4.24, placing them 20th in the league.

They have delivered 38 quality starts, ranking 19th, showing some consistency from their starters. However, with 21 blown saves, their bullpen has struggled to maintain leads late in games.

Team Betting Trends

  • SU as Underdog: 56-88 (38.9%)
  • SU in Away Games: 25-47 (34.7%)
  • Runline as Underdog: 87-57 (60.4%)
  • Runline in Away Games: 43-29 (59.7%)
  • O/U as Underdog: 70-74 (48.6%)

Guardians vs White Sox Prediction: Guardians -172

The Cleveland Guardians have been performing well lately, with a strong 7-3 record over their last 10 games. They have shown consistency at home with a 38-34 record and a solid 25-14 division record. With Tanner Bibee on the mound, despite his higher ERA, the Guardians’ overall team momentum provides an edge against the White Sox.

On the other hand, the Chicago White Sox have struggled throughout the season, especially on the road with a 25-47 record. While Martín Pérez has shown promise with a 3.15 ERA, the White Sox’s inconsistent performance and poor divisional record of 18-31 are concerning. Their recent positive streak might not be enough to overcome the Guardians in Cleveland.

Historical matchups also favor the Guardians, as they have outscored the White Sox by an average of 1.7 runs in their last 10 encounters. The Guardians’ ability to maintain a winning streak after a victory (42-32) further supports their chances in this game. Considering these factors, the Guardians present a more reliable pick.

Despite Pérez’s pitching capabilities, the Guardians’ lineup, led by recent contributions from players like C.J. Kayfus, is expected to secure a narrow victory. I project a final score of Cleveland Guardians 4 – Chicago White Sox 3.

  • Guardians vs White Sox Prediction: Guardians -172
  • Guardians vs White Sox Score: Guardians 4 – White Sox 3
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