NFL Game Prediction

Cardinals vs Panthers Prediction & Betting Tips for NFL Week 2 on 9/14/2025

Want our best Cardinals vs Panthers prediction for NFL week 2 on 9/14/25? Get our NFL betting tip as the Carolina Panthers travel to the Arizona Cardinals on 9/14/25 at State Farm Stadium, in Arizona. Knup Sports has your free pick!

The Carolina Panthers are set to visit the Arizona Cardinals in Week 2 of the 2025 NFL season. The game will take place at State Farm Stadium in Glendale, Arizona, and will be aired on CBS at 4:05 PM. Both teams come into this game with differing fortunes from their opening week performances. Carolina, under head coach Dave Canales, is looking to bounce back from a 26-10 defeat against the Jacksonville Jaguars. The Panthers managed only 142 passing yards in their Week 1 loss. The team will need a stronger performance to contend with Arizona’s defense. The Arizona Cardinals, led by head coach Jonathan Gannon, will aim to continue their positive start following a 20-13 victory over the New Orleans Saints. With a record of 1-0, the Cardinals have the advantage of playing at home. Their effective rushing attack, which amassed 146 yards last week, could be a key factor in this game.

Cardinals vs Panthers At a Glance

  • Game Location: State Farm Stadium in Glendale, AZ
  • Game Date and Time: Sunday, September 14, 2025 at 4:05 PM
  • TV Coverage: CBS
  • Cardinals Current Record: 1-0-0
  • Panthers Current Record: 0-1-0
  • Consensus Odds: Cardinals favored with a -297 moneyline, Panthers at +241

Arizona Cardinals: A Look Ahead to Their Upcoming Game

Offensive Capabilities

The Arizona Cardinals ended the last regular season with a strong offensive showing, ranking 12th in total score with 400 points. Their passing game ranked 18th, producing 3,639 yards, while their rushing attack was notably impressive, ranking 7th with 2,451 yards.

Securing 356 first downs placed them in 8th position, showcasing their ability to sustain drives. Additionally, their third-down conversion rate was also ranked 8th, with a 43% success rate.

Defensive Performance

Defensively, the Cardinals allowed 379 points, placing them 14th in opponent scoring. They managed to accumulate 41 sacks, ranking 8th in this category, indicating a strong pass rush.

In terms of turnovers, they ranked 11th with 9 interceptions and 7th with 8 fumbles recovered. However, they ranked 21st in opponent offensive yards, allowing 5,823 yards, which suggests some vulnerability in yardage defense.

Recent Game Analysis

In their recent game against the New Orleans Saints, the Cardinals emerged with a 20-13 victory. Despite gaining fewer first downs and passing yards than the Saints, they dominated the ground game with 146 rushing yards.

Kyler Murray’s efficiency was evident with 21 completions for 163 yards and 2 touchdowns. Marvin Harrison Jr. was a standout receiver with 71 yards and a touchdown.

Player Highlights

James Conner contributed significantly to the rushing attack with 39 yards and added 4 receptions. Trey Benson led the rushing efforts with 69 yards and a reception, showcasing depth in the running back position.

Defensively, Budda Baker and Jalen Thompson were key players, each contributing multiple tackles. Max Melton also made his presence felt with solid defensive stats.

Injury Report Impact

The Cardinals are dealing with several injuries, impacting their depth, especially on the defensive line and secondary. Players like Justin Jones and Bilal Nichols are out, potentially affecting their defensive front.

With key players like Will Hernandez and Zaven Collins listed as questionable, the team’s depth will be tested, especially against high-powered offenses.

Team Betting Trends

  • SU Last 3: 1-0 (100.0%)
  • SU Last 5: 1-0 (100.0%)
  • SU Last 10: 1-0 (100.0%)
  • SU All Games: 1-0 (100.0%)
  • SU as Favorite: 1-0 (100.0%)
  • SU in Day Games: 1-0 (100.0%)
  • SU in Away Games: 1-0 (100.0%)
  • ATS Last 3: 1-0 (100.0%)
  • ATS Last 5: 1-0 (100.0%)
  • ATS Last 10: 1-0 (100.0%)
  • ATS All Games: 1-0 (100.0%)
  • ATS as Favorite: 1-0 (100.0%)
  • ATS in Away Games: 1-0 (100.0%)
  • O/U Last 3: 0-1 (0.0%)
  • O/U Last 5: 0-1 (0.0%)
  • O/U Last 10: 0-1 (0.0%)
  • O/U All Games: 0-1 (0.0%)
  • O/U as Favorite: 0-1 (0.0%)
  • O/U in Away Games: 0-1 (0.0%)

Carolina Panthers: A Closer Look at Their Upcoming Battle

Offensive Performance Overview

The Carolina Panthers’ offense ranked 22nd in scoring last season, tallying 341 points. Their passing game struggled significantly, ranking 30th with just 3,188 passing yards.

In the rushing department, they fared better, securing the 18th spot with 1,878 rushing yards. However, their third-down conversion rate of 36% also placed them at 22nd, indicating room for improvement.

Defensive Struggles

The Panthers’ defense allowed 534 points last season, ranking them 29th in opponent scoring. They managed to secure a mid-table position in sacks with 32, ranking 16th.

While they did well in recovering fumbles (7th) and intercepting passes (11th), their overall defensive performance was hampered by giving up 6,877 opponent offensive yards, the highest in the league.

Recent Performance Recap

In their recent game against the Jacksonville Jaguars, the Panthers were defeated 26-10. Despite achieving 15 first downs, they were outperformed by the Jaguars’ 19.

The Panthers accumulated 142 passing yards and 113 rushing yards, but turnovers proved costly with two interceptions and one fumble in the game.

Key Players to Watch

Quarterback Bryce Young completed 18 passes for 154 yards with one touchdown but threw two interceptions. Running back Chuba Hubbard made a notable impact with 57 rushing yards and three receptions.

On the receiving end, Tetairoa McMillan led with five receptions for 68 yards. Defensive standout Tre’von Moehrig recorded seven solo tackles and four assists, showcasing his tackling ability.

Upcoming Game Preview

The Panthers are set to face the Arizona Cardinals at State Farm Stadium on September 14, 2025. With an eye on bouncing back, the Panthers will aim to refine their offensive and defensive strategies.

Key players like Bryce Young and Chuba Hubbard will need to step up, especially with the Panthers’ recent offensive struggles. The team’s ability to convert on third downs will be crucial against the Cardinals.

Injury Concerns

The Panthers have several players on the injury list, including Tershawn Wharton, who is out with a hamstring injury. Other notable absentees include Damarri Mathis with a torn ACL and Jonathon Brooks, also out for the season with a knee injury.

Injury concerns may impact the team’s depth, especially on defense, making it imperative for available players to perform at their best.

Carolina Panthers Betting Trends

  • SU All Games: 0-1 (0.0%)
  • ATS All Games: 0-1 (0.0%)
  • O/U All Games: 0-1 (0.0%)
  • SU in Away Games: 0-1 (0.0%)
  • ATS in Away Games: 0-1 (0.0%)
  • O/U in Away Games: 0-1 (0.0%)

Cardinals vs Panthers Prediction: Cardinals -6.5

The Arizona Cardinals come into this game with a strong start to their season, holding a 1-0 record. Their offensive ranking from last season, 12th in scoring and 18th in passing yards, suggests they have the capability to put points on the board. With home-field advantage at State Farm Stadium, the Cardinals are positioned well to cover the -6.5 spread.

On the other hand, the Carolina Panthers have struggled out of the gate, with an 0-1 record. The Panthers’ offense ranked 22nd in scoring last season, which could be problematic against the Cardinals’ defense, ranked 14th in opponent scoring. The Panthers’ road struggles continue, as their road record this season is already 0-1.

The Cardinals’ solid defensive stats from last season, including 8th in sacks and fumbles recovered, bolster their chances of containing the Panthers’ offensive efforts. Given these statistics and their previous ATS success, the Cardinals are likely to cover the -6.5 spread.

Considering the stats and recent performances, the projected final score supports a comfortable Cardinals win. This aligns with their overall positive ATS trends when favored, making them a strong pick for this game.

  • Cardinals vs Panthers Prediction: Cardinals -6.5
  • Cardinals vs Panthers Score: Cardinals 28 – Panthers 17
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