MLB Game Prediction

Seattle Mariners vs St. Louis Cardinals Prediction & Betting Tips for 9/10/2025

Want our best Seattle Mariners vs St. Louis Cardinals prediction for 9/10/25? Get our MLB betting tip as the Cardinals travel to the Mariners on 9/10/25 at T-Mobile Park, in Seattle. Knup Sports has your free pick!

The St. Louis Cardinals, currently sitting fourth in the NL Central with a 72-73 record, head to Seattle to take on the Mariners. Under the guidance of manager Oliver Marmol, the Cardinals have shown resilience, posting a 6-4 record in their last ten games despite dropping their most recent outing to the Mariners. With a road record of 31-39, they’ll look to reverse their fortunes at T-Mobile Park.

On the other side, the Seattle Mariners are riding high with a 76-68 record, currently ranked second in the AL West. Led by manager Dan Wilson, the Mariners have won their last three games, putting together an impressive home record of 42-27. The matchup at T-Mobile Park comes after Seattle’s recent 4-2 victory over the Cardinals, further boosting their confidence.

The game is set to be played under clear skies with a warm evening forecasted, though the retractable roof at T-Mobile Park means weather conditions are unlikely to affect the game. The Mariners are favored with a moneyline of -226, while the Cardinals stand at +189. Fans can catch all the action at 9:40 PM on FDSMW as the two teams look to improve their standings in their respective divisions.

Mariners vs Cardinals At a Glance

  • Game Location: T-Mobile Park in Seattle, WA
  • Game Time: September 10, 2025, at 9:40 PM (Night Game)
  • Weather: Clear sky with a light breeze; wind may not impact play due to retractable roof
  • TV Broadcast: FDSMW
  • Cardinals Moneyline Odds: +189
  • Mariners Moneyline Odds: -226

Seattle Mariners: Battling the Cardinals with Momentum

Team Overview

The St. Louis Cardinals have a challenging task as they prepare to face the Seattle Mariners, who recently secured impressive wins against the Braves and the Cardinals. This season, the Cardinals’ offensive lineup features a batting average of .243, placing them 13th in the league.

They have achieved a respectable on-base percentage of .318, ranking 9th overall. With a slugging percentage of .415, they also hold the 9th position, showcasing their ability to make impactful hits.

Power Hitters and Offensive Potential

The Cardinals have demonstrated significant power at the plate, tallying 210 home runs, ranking 2nd in the league. Their ability to hit the long ball could play a critical role in their strategy against the Mariners.

However, their total doubles rank 25th with 196, indicating some inconsistency in hitting for extra bases beyond home runs. They have drawn 482 walks, placing them 9th, which underscores their discipline and patience at the plate.

Base Running and Strikeouts

On the base paths, the Cardinals have successfully stolen 141 bases, ranking 4th, which highlights their aggressive approach and potential to disrupt the Mariners’ defense. Their strikeout total stands at 1,277, placing them 25th, suggesting vulnerabilities in their lineup against high strikeout pitchers.

The Mariners’ pitchers will look to exploit this and keep the Cardinals’ hitters off balance with strategic pitch selections.

Pitching Overview

Pitching will be pivotal for the Cardinals, who have recorded a team ERA of 4.00, ranking 17th in the league. The Mariners’ lineup, with their recent offensive success, will challenge the Cardinals’ pitching staff.

Opponents have batted .244 against the Cardinals, placing them 13th in batting average against, which indicates a solid, though not overpowering, pitching performance. They have also allowed 172 home runs, ranking 13th, showing a need to manage power hitters effectively.

Betting Trends

  • SU as Favorite: 54-45 (54.5%)
  • SU in Away Games: 34-41 (45.3%)
  • Runline All Games: 59-85 (41.0%)
  • O/U All Games: 77-67 (53.5%)
  • O/U in Away Games: 43-32 (57.3%)

Cardinals Aim to Bounce Back Against Mariners: A Closer Look at the Matchup

Mariners’ Season Overview

The Seattle Mariners have had a mixed bag of performances this season, as evidenced by their 4.29 ERA, placing them 21st in the league. Their batting lineup has struggled slightly, with a .245 batting average ranked 11th overall.

Despite their offensive challenges, Seattle has managed to deliver 137 home runs, ranking them 23rd. Their pitching staff has given up 148 home runs, placing them fifth in that category, a statistic that could be concerning against power-hitting teams.

Key Players to Watch

Logan Gilbert takes the mound for the Mariners with a respectable ERA of 3.61 and WHIP of 1.02. With a 4-6 record, Gilbert’s performance can sway games, and he has the potential to keep the Cardinals’ bats quiet.

Offensively, the Mariners will rely on a balanced approach to counter the Cardinals. While their slugging percentage is lower than desired at .380, they have proven capable of stringing hits together when needed.

Recent Performances

In their last encounter, the Mariners secured a 4-2 victory over the Cardinals. Seattle’s pitching outperformed, limiting the Cardinals to three hits, one of which was a home run.

Bryan Woo led the charge from the mound with six strong innings, allowing just three hits and striking out nine, showcasing the depth of Seattle’s pitching rotation.

Team Betting Trends

  • Last 3 Games (SU): 2-1
  • Last 5 Games (SU): 3-2
  • Overall (SU): 72-73
  • As Favorite (SU): 33-32
  • As Underdog (SU): 39-41
  • Night Games (SU): 44-42
  • Away Games (SU): 31-39

Seattle’s ability to perform under pressure in away games will be tested as they look to improve on their 44.3% success rate. While their home performance has been stronger, they still need to address inconsistencies on the road.

The Mariners’ recent games have been low-scoring, with the over/under trend at 0-3 in the last three games, indicating a solid defensive stance. They will look to maintain this defensive prowess against the Cardinals.

Mariners vs Cardinals Prediction: Cardinals +189

The Seattle Mariners are the favorites in this matchup, but the value lies with the St. Louis Cardinals at +189. Despite the Mariners being on a three-game winning streak, the Cardinals have a solid recent form of 6-4 in their last 10 games, suggesting they can compete strongly. Additionally, the Cardinals’ recent activation of Willson Contreras could provide a boost to their lineup and overall strategy.

Logan Gilbert takes the mound for Seattle, boasting a respectable 3.61 ERA, but his win-loss record of 4-6 indicates vulnerability. Meanwhile, Michael McGreevy, with a 6-3 record, provides the Cardinals with a solid pitching option, despite a higher ERA of 4.68. Given the Mariners’ last 10 game record of 4-6 and McGreevy’s potential to limit runs, the Cardinals have a viable chance to upset.

In their previous encounter, the Mariners secured a 4-2 win, but with the Cardinals showing resilience and potential roster improvement, a close contest is expected. The Cardinals’ road record of 31-39 doesn’t inspire confidence, but with an improving form and strategic adjustments, they could edge out Seattle. The prediction leans towards a narrow victory for the Cardinals.

Anticipating a competitive game, a projected final score could be Cardinals 5 – Mariners 4, with the Cardinals leveraging their recent form and strategic changes to claim victory. The odds at +189 offer a strong value play for those siding with the underdog.

  • Mariners vs Cardinals Prediction: Cardinals +189
  • Mariners vs Cardinals Score: Cardinals 5 – Mariners 4
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