Arizona Cardinals vs San Francisco 49ers Matchup

Read on to get betting odds and analysis in our week 5 Cardinals vs 49ers pick and preview and see who we think will win and cover in Santa Clara.

On the money line, the 49ers are -358 favorites as they host the Cardinals at 4:05 ET on Sunday, October 6th at Levi's Stadium in Santa Clara, CA. The 49ers are favored by -7.5 points, and the over/under line is at 49.5 points. This week five NFC West matchup is being televised on FOX.

Cardinals vs. 49ers Matchup At A Glance

Sport: NFL
Teams: Arizona Cardinals at San Francisco 49ers
Where: Santa Clara at Levi's Stadium
Date: Sunday, October 6th
Betting Odds SF -7.5, ARI +280 | SF -358 O/U 49.5

Cardinals Preview:

The Arizona Cardinals are now 1-3 following a 42-14 blowout loss to the Washington Commanders. Arizona was favored by -3.5 at home but lost by 28 points. The combined 56 points exceeded the over/under line of 48.5 points. The Commanders took a 7-7 tie into the 2nd quarter and then outscored the Cardinals 35-7 over the next two quarters.

Arizona's only touchdown came on a Kyler Murray to Marvin Harrison Jr. pass in the 1st quarter. Washington then scored 10 unanswered points in the 2nd quarter and added another touchdown in the 3rd and 4th quarters each. The Cardinals added a touchdown with 15 seconds left in the 3rd quarter on a James Conner run, but by then, they were already trailing 27-7.

Cardinals Offense Breakdown

Despite the Cardinals rushing for 181 yards on 32 attempts, they were limited to just 115 passing yards in their 42-14 loss to the Washington Commanders. Kyler Murray completed 72% of his passes for 142 yards and one touchdown. He was sacked four times. Arizona finished with 17 first downs and 449 total yards.

James Conner led the ground game with 104 yards, averaging 5.8 yards per attempt, and finding the endzone once. Marvin Harrison Jr. was the leading receiver with 45 yards and a touchdown. The offense struggled on third down, converting just 36.4% of their chances.

Cardinals Team Defense

Arizona's defense struggled to stop the run in their 42-14 loss to the Commanders, giving up 216 yards on the ground and 5.8 yards per attempt. They also allowed Washington to convert on 75% of their third down attempts. Despite this, they did force one interception and held Washington to 233 passing yards.

Overall, the Cardinals allowed 449 total yards and 86.7% completion percentage. They also gave up a big day in the running game to the Commanders, who averaged 5.8 yards per attempt on 37 carries.

49ers Preview:

The 49ers are now 2-2 after their 30-13 win over the Patriots. San Francisco took a 6-0 lead after the 1st quarter and extended it to 20-3 by halftime. They also covered the spread as 10.5-point favorites, with the combined 43 points going over the 42-point line.

In the 4th quarter, the Patriots closed the gap to 27-13, but Brock Purdy's touchdown pass to Juan Jennings and a late field goal sealed the win for the 49ers. Purdy had a strong game, throwing four touchdown passes, including two to Jennings and one each to Brandon Aiyuk and Deebo Samuel Sr.

49ers Offense Breakdown

The 49ers' offense picked up 19 first downs in their 30-13 win over the Patriots, racking up 283 yards through the air and 148 yards on the ground. They converted on 53.8% of their third down attempts and averaged 10.5 yards per attempt in the passing game. Brock Purdy completed 15 of 27 passes for 288 yards, with one touchdown and one interception.

Jordan Mason led the team in rushing with 123 yards on 24 carries, including a long run of 25 yards and one touchdown. Jauan Jennings was the top receiver, finishing with 88 yards on three catches, including a 45-yard reception.

49ers Team Defense

In their most recent game, the 49ers' defense was dominant, coming away with six sacks and allowing just 143 passing yards in their 30-13 win over the Patriots. New England managed only 216 total yards and was limited to 73 rushing yards on 24 attempts. The 49ers also defended well on third downs, allowing only a 31.2% conversion rate.

Despite giving up one passing touchdown, the 49ers' secondary picked off one pass and held the Patriots to a 59.4% completion rate. San Francisco also had six more quarterback hits than the Patriots and four tackles for loss.

Cardinals vs 49ers Betting Odds, Trends & Analysis

Across the Cardinals last ten road games, the team averaged 17 points per game while allowing 25. Their record vs the spread in these contests was 5-5, while going 2-8 straight-up.
When looking at their past three home matchups, San Francisco has an ATS record of 0-3 while averaging 21 per game. The team went 0-3 overall in these games.
As the betting underdog, the Cardinals have an ATS mark of just 6-4 in their last ten games. Arizona posted a straight up mark of 3-7 in these matchups.
In their last five games as the betting favorite, the 49ers have a straight up record of 2-3 and an ATS mark of 2-3.