The 2025 NFL season in Week 4 features an intriguing game between the Jacksonville Jaguars and the San Francisco 49ers. Taking place at Levi’s Stadium in Santa Clara, CA, this outdoor afternoon game is set for Sunday, September 28, at 4:05 PM and will be broadcast on FOX. The weather details remain unspecified, adding an element of unpredictability to the matchup.
The Jacksonville Jaguars enter this game with a 2-1 record, having demonstrated strong performances at home with a 2-0 record but struggling on the road at 0-1. Led by Head Coach Liam Coen, the Jaguars will look to improve their road performance against a tough opponent. Their previous game saw them secure a 17-10 victory over the Houston Texans at EverBank Stadium.
The San Francisco 49ers, under the guidance of Head Coach Kyle Shanahan, boast an impressive 3-0 record this season. Holding a 1-0 home record, the 49ers have shown their ability to win both at home and on the road. Their recent narrow 16-15 win over the Arizona Cardinals at Levi’s Stadium demonstrates their knack for close games.
49ers vs Jaguars At a Glance
- Game Date & Time: Sunday, September 28, 2025, at 4:05 PM (Afternoon Game)
- Location: Levi’s Stadium in Santa Clara, CA USA — Outdoor Field
- TV Broadcast: FOX
- San Francisco 49ers Record: 3-0-0, leading NFC West
- Jacksonville Jaguars Record: 2-1-0, competing in AFC South
- Game Odds: 49ers favored with a -174 moneyline, and a -3.0 spread (-116)
The San Francisco 49ers: A Comprehensive Look at Their Performance This Season
Offensive Performance
The San Francisco 49ers have demonstrated a potent offensive attack this season, ranking 4th in passing yards with a total of 4,234. Their ability to move the ball through the air has been a key factor in their success, complemented by their 12th-ranked rushing yards at 2,163. Additionally, they have been effective in converting third downs, achieving a 42.6% conversion rate, which places them 9th in the league.
Scoring has been a significant aspect of their offense, with the team accumulating a total of 389 points, ranking 13th. This balanced offensive approach has enabled them to maintain pressure on opposing defenses and sustain drives.
Defensive Insights
On the defensive side, the 49ers have allowed 436 points, placing them 26th in the league. Despite this, their defensive unit has excelled in other areas, such as recovering 6 fumbles and recording 11 interceptions, both ranking 9th in the league. Their ability to create turnovers has been pivotal in offsetting some of the points allowed.
The 49ers’ defense has also been effective in limiting opponent offensive yards, ranking 8th with 5,396 yards allowed. This demonstrates their capability to contain and challenge opposing offenses consistently.
Recent Game Performance
In their recent games, the 49ers secured a narrow victory against the Arizona Cardinals, winning 16-15. Mac Jones was a key player, throwing for 284 yards and 1 touchdown, though he also had an interception. Their defense contributed significantly, with Bryce Huff recording a sack.
Earlier in the season, they defeated the New Orleans Saints 26-21, showcasing a strong passing game with Jones throwing 279 yards and 3 touchdowns. Fred Warner’s defensive presence was felt with 7 solo tackles, proving crucial in their defensive efforts.
Key Player Contributions
Mac Jones has been a standout player, leading the team with 563 passing yards over two games, ranking 1st within the team. His ability to connect with receivers like Ricky Pearsall, who has 281 receiving yards, has been essential for the team’s success.
Christian McCaffrey has been a versatile asset, contributing 176 rushing yards and 213 receiving yards, highlighting his dual-threat capability. His performance is integral to the 49ers’ offensive strategies.
Injury Report
The 49ers are currently dealing with several injuries that could impact their performance. Notably, George Kittle is out with a hamstring injury and placed on injured reserve, missing at least four games. Nick Bosa’s absence due to a torn ACL is another significant loss for the defensive line.
Jauan Jennings is listed as questionable with ankle and shoulder injuries, which could affect the depth at the wide receiver position. Brock Purdy is also questionable for Week 4 with a shoulder and toe injury, potentially affecting the quarterback depth.
San Francisco 49ers Betting Trends
- SU – All Games (REG): Last 3 REG Games (2025) → 3-0 (100.0%)
- SU – As Favorite (REG): Last 3 REG Games (2025) → 3-0 (100.0%)
- O/U – After Loss (REG): Last 8 REG Games (2024–2025) → 6-2 (75.0%)
- ATS – As Favorite (REG): Last 9 REG Games (2024–2025) → 6-3 (66.7%)
- O/U – As Underdog (REG): Last 4 REG Games (2024) → 3-1 (75.0%)
- O/U – Away Games (REG): Last 4 REG Games (2024–2025) → 3-1 (75.0%)
- O/U – All Games (REG): Last 6 REG Games (2024–2025) → 4-2 (66.7%)
- ATS – All Games (REG): Last 3 REG Games (2025) → 2-1 (66.7%)
- SU – Away Games (REG): Last 3 REG Games (2024–2025) → 2-1 (66.7%)
- ATS – Away Games (REG): Last 3 REG Games (2024–2025) → 2-1 (66.7%)
Jaguars Seek to Roar in San Francisco Showdown
Offensive Performance
The Jacksonville Jaguars’ offense has been inconsistent, ranking 24th in both scoring and passing yards during the 2024 season. Their rushing game also struggled, ranking 25th with 1729 yards. This offensive inconsistency has resulted in a 27th rank for first downs.
Despite these challenges, quarterback Trevor Lawrence has been a bright spot with 671 passing yards over three games, ranking him 12th in the league. His connection with wide receiver Dyami Brown, who is averaging 38.7 receiving yards per game, will be crucial against the 49ers.
Defensive Struggles
Defensively, the Jaguars have had their struggles, allowing 435 points in the 2024 season, ranking 25th. Their pass rush has been somewhat effective with 34 sacks, placing them 15th in the league. However, they have allowed a staggering 6629 opponent offensive yards, ranking 31st.
Travon Walker has been a defensive standout with two sacks in the past two games. The Jaguars will need more defensive plays like his to contain the 49ers’ potent offense.
Key Players and Injuries
Running back Travis Etienne Jr. has been a significant contributor with 270 rushing yards in three games, ranking 3rd in the league. His ability to break free in the running game could be pivotal for the Jaguars’ success.
Injuries could impact the Jaguars’ performance, with wide receiver Dyami Brown questionable due to a shoulder injury. The offensive line is also affected, with Cooper Hodges and Wyatt Milum dealing with injuries.
Betting Trends
- O/U – After Win (REG): 4-0 (100%) in last 4 games.
- SU – As Favorite (REG): 3-0 (100%) in last 3 games.
- ATS – As Favorite (REG): 3-0 (100%) in last 3 games.
- O/U – Away Games (REG): 5-2 (71.4%) in last 7 games.
- SU – As Underdog (REG): 2-4 (33.3%) in last 6 games.
Recent Game Insights
The Jaguars recently secured a 17-10 victory over the Houston Texans, showcasing a balanced attack with 205 passing yards and 86 rushing yards. This win highlights their potential to overcome offensive struggles.
Earlier, they suffered a narrow 31-27 loss to the Cincinnati Bengals, despite a solid performance from Trevor Lawrence, who threw for 271 yards and three touchdowns. This game underscores the need for consistency on both sides of the ball.
Upcoming Challenges
As the Jaguars prepare to face the San Francisco 49ers, they will need to address their defensive vulnerabilities and improve offensive consistency. The 49ers, known for their strong defense, will test the Jaguars’ offensive line and quarterback Trevor Lawrence.
The Jaguars are 3-point underdogs in this matchup, highlighting the challenge they face on the road. A strong performance from their key players and overcoming injuries will be vital to their success against the 49ers.
49ers vs Jaguars Prediction: 49ers -3.0
The San Francisco 49ers come into Week 4 with an impressive 3-0 record, playing at home where they are currently unbeaten this season. The 49ers have been strong against the spread as favorites, covering in 66.7% of their last nine regular-season games. Their high-powered offense, ranked 4th in passing yards last season, should exploit the Jaguars’ defense, which was ranked 31st in opponent offensive yards allowed.
On the other side, the Jacksonville Jaguars have struggled on the road with a 0-1 record this season. Their offense, ranked 24th in scoring last season, may find it difficult to keep up with the 49ers’ balanced attack. Historically, the 49ers have dominated head-to-head matchups, winning their last meeting 34-3, which showcases their ability to control games against Jacksonville.
The 49ers’ defensive unit, which ranked 8th in opponent offensive yards allowed last season, is likely to contain the Jaguars’ offense effectively. Given the 49ers’ trends and home advantage, they are well-positioned to cover the -3.0 spread in this game. With Kyle Shanahan’s team playing at home, expect them to maintain their winning streak.
Given the teams’ current form and statistical rankings, the San Francisco 49ers appear to have the upper hand in this contest. We project the 49ers to secure a comfortable victory at home.
- 49ers vs Jaguars Prediction: 49ers -3.0
- 49ers vs Jaguars Score: 49ers 31 – Jaguars 20
