In this week 12 NFL regular season preview between Lions and Colts, see who like to win the game and cover the spread.
With a money line of -365, the Lions are the heavy favorites over the Colts in their week 12 non-conference matchup. The game, set for 1:00 ET on Sunday, November 24th at Lucas Oil Stadium in Indianapolis, is being televised on FOX. The Colts are +290 on the money line, and the Lions are favored by -7.5 points. The over/under line is currently at 51 points.
Lions vs. Colts Matchup At A Glance
- Sport: NFL
- Teams: Detroit Lions at Indianapolis Colts
- Where: Indianapolis at Lucas Oil Stadium
- Date: Sunday, November 24th
- Betting Odds DET -7.5, DET -365 | IND +290 O/U 51

Lions Preview:
With an eight-game winning streak, the Lions sit at 9-1, putting them at the top of both our power rankings and the NFC standings. Our projections give Detroit a 99.9% chance of making the playoffs and an 84.7% chance of winning the NFC North. They are 2-0 in division games and 6-1 in conference play. They are 5-0 on the road and 4-1 at home.
Detroit is 8-2 against the spread, with an average scoring margin of +15.9 points per game. In week 11, they easily covered the 14-point spread by beating the Jaguars 52-6. The combined scoring of 58 points went over the 47.5-point line. The Lions’ O/U record is 5-4-1 this season.
Lions Offense Breakdown
Jared Goff bounced back from a 5-interception game in week 10 with a stellar performance against the Jaguars in week 11, throwing for 412 yards and 4 touchdowns on 24/29 passing. He finished with a perfect passer rating of 158.3 and was not sacked. Amon-Ra St. Brown led the receiving corps with 11 catches for 161 yards and 2 touchdowns, while David Montgomery added 75 rushing yards and 2 touchdowns on 15 carries.
Detroit's offense is currently ranked 2nd in our power rankings, leading the NFL with 33.6 points per game. They rank 3rd in total yards per game (394.7) and are 6th in passing yards, despite being 26th in pass attempts. The Lions also rank 3rd in rushing yards per game, with 32.3 attempts per game.
Lions Team Defense
In their most recent game, the Lions' defense was dominant, giving up just 170 yards and forcing one interception. They allowed the Jaguars to convert only 20% of their third down attempts and held them to 41 yards rushing on just 17 attempts. Detroit also limited Jacksonville to 129 yards passing and did not allow a passing touchdown.
Detroit's defense put a lot of pressure on the quarterback, finishing with one sack and winning the quarterback hit differential. The Lions came out on top in this game, winning 52-6.Colts Preview:
With a 5-6 record, the Colts sit 2nd in the AFC South and 8th in the conference standings. Our projections give them a 32.6% chance of making the playoffs and a 5.0% chance of winning the division. Indianapolis ranks 25th in our NFL power rankings heading into week 12.
Despite their negative scoring margin (-1.3), the Colts have an 8-3 record against the spread, including a 6-2 mark as underdogs. Their O/U record is 5-6, with the over hitting in their last two games. In week 11, they beat the Jets 28-27, covering the spread as 4-point underdogs.
Colts Offense Breakdown
Heading into week 12, the Colts rank 24th in our offensive power rankings. They are 18th in the NFL in points per game (21.5) and 21st in total yards per game (320.7). Indianapolis ranks 20th in both passing attempts (30.4) and passing yards per game (202.2), while they sit 16th in rushing yards per game, averaging 118.5 on 26.5 attempts per game. The Colts are 19th in the league in 3rd-down conversions, with a 37% success rate, and they rank 17th in red zone conversion percentage.
Anthony Richardson threw for 272 yards and a touchdown in week 11, completing 20 of 30 passes without an interception. Jonathan Taylor rushed for 57 yards on 24 carries, while Josh Downs led the team with 5 receptions for 84 yards. The Colts scored 12 points in the 4th quarter and converted 6 of 15 3rd-down attempts, along with 3 of 4 red zone opportunities.
Colts Team Defense
In their 28-27 win over the Jets, the Colts' defense gave up 162 passing yards on 22 completions. The Colts allowed two passing touchdowns and the Jets had a 75.9% completion percentage. Indianapolis defended the run well, allowing just 91 yards on 20 attempts (4.6 avg). On third downs, the Colts allowed the Jets to convert 30.8% of their chances.
The Colts' defense also managed three sacks in the game, and although they allowed 253 total yards, the Jets were unable to capitalize with a win.Lions vs Colts Betting Odds, Trends & Analysis
- Through their last ten road contests, the Lions offense has averaged 27 points per game while allowing an average of 22. Detroit posted an overall record of 7-3 while going 8-2 ATS.
- Across their last five home contests, Indianapolis has a 4-1 record vs the spread. Their overall mark in these games was 2-3, while averaging 23 points per game.
- Spanning across their last five games as the betting underdog, the Colts have gone 3-2 vs the spread. Their overall record in these games was 2-3.
- The Lions have played well in their last three games as the betting favorite, going 3-0 straight up and 2-1 against the spread.
Lions vs Colts Free Pick
- KnupSports.com Free Betting Pick: Lions -7.5 Be sure to check out our other NFL Football betting previews for this week. KnupSports.com also updates their sports betting picks page daily with plays across all sports.